2024年：
155. Chen, C.-C.,# Li, X.,# Min, J.,# Zeng, Z.-Y., Ning, Z.-Y., He, H.-L., Long, X., Niu, D., Peng, R.-M., Liu, X., Yang, Y., Huang, J.-W., Chen C.-C,* Guo R.-T.,* Complete decomposition of poly(ethylene terephthalate) by crude PET hydrolytic enzyme produced in Pichia pastoris. Chemical Engineering Journal, 2024, Accepted.
154. Liu, M.,# Yang, Y., # Huang J.-W., Dai L.-H., Zheng Y.-Y, Cheng S.-J, He H.-L., Chen C.-C,* Guo R.-T.,*Structural insights into a novel nonheme iron-dependent oxygenase in selenoneine biosynthesis. International Journal of Biological Macromolecules, 2024, Accepted.
2023年：
153. Yang, Y.,# Cheng, S.,# Zheng, Y.,# Xue, T., Huang, J.-W., Zhang, L., Yang, Y., Guo, R.-T.,* Chen, C.-C.* Remodeling the polymer-binding cavity to improve the efficacy of PBAT-degrading enzyme. Journal of Hazardous Materials, 2023, Accepted. https://doi.org/10.1016/j.jhazmat.2023.132965
152. Li, H.,# Huang, J.-W.,# Dai, L.,# Zheng, H., Dai, S., Zhang, Q., Yao, L., Yang, Y., Yang, Y., Min, J., Guo, R.-T.,* Chen, C.-C.* The structural and functional investigation into an unusual nitrile synthase. Nature Communications, 2023, Accepted.
151.Yuan, L.,# Ma, X.,# Yang, Y.,# Qu, Y., Li, X., Zhu, X., Ma, W., Duan, J., Xue, J., Yang, H., Huang, J.-W., Yi, S., Zhang, M., Cai, N., Zhang, L., Ding, Q., Lai, K., Liu, C., Zhang, L., Liu, X., Yao, Y., Zhou, S., Li, X., Shen, P., Chang, Q., Malwal, S. R., He, Y., Li, W., Chen, C., Chen, C.-C., Oldfield, E., Guo, R.-T.,* Zhang, Y.* Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. Nature, 2023, 621(7980): 840-848
150. Dai, L.,# Niu, D.,# Huang, J.-W.,# Li, X., Shen, P., Li, H., Xie, Z., Min, J., Hu, Y., Yang, Y., Guo, R.-T.,* Chen, C.-C.,* Cryo-EM structure and rational engineering of a superefficient ochratoxin A-detoxifying amidohydrolase. Journal of Hazardous Materials, 2023, 458: 131836.
149. Li, Z.,# Zhang, L.,# Xu, K.,# Jiang, Y., Du, J., Zhang, X., Meng, L.-H., Wu, Q., Du, L., Li, X., Hu, Y., Xie, Z., Jiang, X., Tang, Y.-J., Wu, R.,* Guo, R.-T.,* Li, S.* Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase. Nature Communications, 2023, 14(1): 4001.
148. Li, X.,# Shi, B.,# Huang, J.-W., Zeng, Z., Yang, Y., Zhang, L., Min, J., Chen, C.-C.,* Guo, R.-T.* Functional tailoring of a PET hydrolytic enzyme expressed in Pichia pastoris. Bioresources and Bioprocessing, 2023, 10(1): 26.
147. Xin, L.,# Min, J.,# Hu, H.,# Li, Y.,# Du, C., Xie, B., Cheng, Y., Deng, X., Deng, X., Shen, K., Huang, J., Chen, C.-C., Guo, R.-T.,* Dong, C.,* Zhou, H.* Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer. European Journal of Medicinal Chemistry, 2023, 253: 115328.
146. Li, A.,# Wang, Q.,# Song, X.,# Zhang, X., Huang, J.-W., Chen, C.-C., Guo, R.-T., * Wang, B.,* Reetz, M. T.* Engineering of a P450-based Kemp eliminase with a new mechanism. Chinese Journal of Catalysis. 2023, 47: 191-199.
145.Yang, Y.,#Min, J.,#Xue,T.,Jiang,P.C.,Liu,X.,Peng,R.M.,Huang, J.-W.,Qu,Y.Y., Li, X.,Ma,N.,Tsai,F.-C.,#Dai, L.,#Zhang,Q.,Liu,Y.L.*,Guo, R.-T.,* Chen, C.-C.*.Complete bio-degradation of poly(butylene adipate-co-terephthalate) via engineered cutinases.Nature Communications, 2023, 14(1). (Highlighted by 科技日报, 中国科学报)
144. Zhang, X.,# Shen, P.,# Zhao, J.,# Chen, Y., Li, X., Huang, J.-W., Zhang, L., Li, Q., Gao, C., Xing, Q., Chen, C.-C., Guo, R.-T.,* Li, A.*. Rationally controlling selective steroid hydroxylation via scaffold sampling of a P450 Family. ACS Catalysis, 2023, 13, 1280–1289.
2022年：
143. Chen, Q.,# Li, B.,# Zhang, L.,# Chen, X., Zhu, X., Chen, F., Shi, M., Chen, C.-C., Yang, Y., Guo, R.-T.,* Liu, W., Xu, J., Zheng, G.*. Engineered imine reductase for larotrectinib intermediate manufacture. ACS Catalysis, 2022, 12 (23), 14795-14803.
142. Dai, L.,# Li, H.,# Huang, J.-W.,# Hu, Y.,# He, M., Yang, Y., Min, J., Guo, R.-T.,* Chen, C.-C.*. Structure-based rational design of a short-chain dehydrogenase/reductase for improving activity toward mycotoxin patulin. International Journal of Biological Macromolecules, 2022-12-01, 222: 421-428.
141.Wu, L.,# An, J.,# Jing, X.,# Chen, C.-C., Dai, L., Liu, W.,* Guo, R.-T.,* Nie, Y.*. Molecular insights into the regioselectivity of the Fe(II)/2-ketoglutarate-dependent dioxygenase-catalyzed C-H hydroxylation of amino acids. ACS Catalysis, 2022-09-08, 12: 11586-11596.
140. Zhang, L.,# Zhang, X.,# Min, J.,# Liu, B., Huang, J.-W., Yang, Y., Liu, W., Dai, L., Yang, Y., Chen, C.-C.,* Guo, R.-T.*.. Structural insights to a bi-functional isoprenyl dihposphate synthase that can catalyze head-to-tail and head-to-middle condensation. International Journal of Biological Macromolecules, 2022-08-01, 214: 492-499.
139. Malwal, S. R.,# Shang, N.,# Liu, W., Li, X., Zhang, L., Chen, C.-C., Guo, R.-T.,* Oldfield, E.*. A structural and bioinformatics investigation of a fungal squanlene synthase and comparisons with other membrane proteins. ACS Omega, 2022-06-17, 7 (26): 22601-22612.
138.Chen, C.-C.,# Dai, M.,# Zhang, L.,# Zhao, J., Zeng, W., Shi, M., Huang, J.-W., Liu, W., Guo, R.-T.,* Li, A.*. Molecular basis for a toluene monooxygenase to govern substrate selectivity, ACS Catalysis, 2022-02-13, 12: 2831-2839.
137. Mao,Z.W .,# Xiao, H.Y.,#Shen, P.P.,# Yang, Y.,Xue, J.,Yang, Y.,Shang, Y.,Zhang, L.,Li, X.,Zhang, Y.,Du,Y.,Chen, C. C., Guo, R. T.* and Yonghui Zhang.* KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discovery, 2022,1,25, 8(1):5.
136. Wang, T.,# Yang, Y.,# He, M.,# Liu, M.,Huang, J. W., Min, J., Chen, C. C., Liu,Y., * Lilan Zhang, *, Guo, R. T.* Structural insights into the cyclization of unusual brasilane-type sesquiterpenes. International Journal of Biological Macromolecules, 2022, 4, 30, 209:1784-1791.
135. Li, H.,# Yang, Y.,# Hu Y.,# Chen, C. C., Huang, J. W., Min, J., Dai, L.*, Guo, R. T.*. Structural analysis and engineering of aldo-keto reductase from glyphosate-resistant Echinochloa colona. Journal of Hazardous Materials, 2022. https://doi.org/10.1016/j.jhazmat.2022.129191 (一区, TOP期刊, IF: 10.588)
134. Dai, L.,# Zhang, X.,# Hu Y.,# Shen J., Zhang Q.,Zhang L., Min J., Chen, C. C., Liu Y.,* Huang J. W.*, Guo, R. T.* Structural and functional insights into a nonheme iron- and α-ketoglutarate-dependent halogenase that catalyzes chlorination of nucleotide substrates. Applied and Environmental Microbiology, 2022. https://doi.org/10.1128/aem.02497-21.
133. Zeng, W.,# Li, X.,# Yang, Y.,# Min, J.,# Huang, J. W., Liu, W., Niu, D., Yang, X., Han, X., Zhang, L., Dai, L., Chen, C. C.,* Guo, R. T.* Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy, ACS Catalysis, 2022, 12: 3033-3040.
132. Chen, C. C.,# Dai, M.,# Zhang, L.,# Zhao, J., Zeng, W., Shi, M., Huang, J. W. Liu, W., Guo, R. T.,* Li, A.* Molecular basis for a toluene monooxygenase to govern substrate selectivity, ACS Catalysis, 2022, 12: 2831-2839.(Coverstory, Highlighted by 中国科学报)
131. Hu, Y.,# Li, H.,# Min, J.,# Yu, Y., Liu, W., Huang, J. W., Zhang, L., Yang, Y., Dai, L.,* Chen, C. C.,* Guo, R. T.* Crystal structure and biochemical analysis of the specialized deoxynivalenol–detoxifying glyoxalase SPG from Gossypium hirsutum. International Journal of Biological Macromolecules, 2022, 200, 388-396.
2021年：
130. 陈纯琪，韩旭，刘卫东，马立新，刘珂*，郭瑞庭*. 基于结构改造来源于大阪伊德氏杆菌 201-F6 的 PET 水解酶，生物工程学报，2021, 37(9): 3268-3275.
129. Dai, L.,# Chang, Z.,# Yang, J., Liu, W., Yang, Y., Chen, C. C., Zhang, L., Huang, J. W., Sun, Y.,* Guo, R. T.* Structural investigation of a thermostable 1,2- b -mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochemical and Biophysical Research Communications, 2021, 579, 54-61.
128. Dai, L.,# Qu, Y.#, Hu, Y.,# Min, J., Yu, X., Chen, C. C., Huang J. W.,* Guo R. T.*Catalytically inactive lytic polysaccharide monooxygenase PcAA14A enhances the enzyme-mediated hydrolysis of polyethylene terephthalate, International Journal of Biological Macromolecules, 2021, 190, 456-462.
127. Chen,C. C.,#Han, X.,#Li, X.,#Jiang, P., Niu, D., Ma, L., Liu, W., Li S., Qu, Y., Hu, H., Min, J., Yang, Y., Zhang L.,Zeng, W., Huang J. W.,* Dai,L.,*Guo R.T.*The general features to enhance enzymatic activity of hydrolyzing poly(ethylene terephthalate), Nature Catalysis, 2021, 4, 425-430. (Highlighted by Chemistry Views, 科技日报, 中国科学报)
126. Dai, L.,Hu, Y.,Chen, C. C.,Ma, L.,*Guo, R. T.*Flavonoid C-glycosyltransferases: function, evolutionary relationship, catalytic mechanism and protein engineering, ChemBioEng Reviews, 2021, 21(1): 15-26.
125. Liu, W.,#Ma, C.,#Liu, W.,#Zheng, Y., Chen, C. C., Liang, A., Luo, X., Li, Z., Ma, W., Song, Y.,*Guo, R. T.,*Zhang, T.* Functional and structural investigation of a novel β-mannanase BaMan113A from Bacillus sp. N16-5. International Journal of Biological Macromolecules, 2021, 182, 899-909.
124. Dai, L.,#Qu, Y.,#Huang, J. W., Hu, Y., Hu, H., Li, S., Chen, C. C.,*Guo, R. T.* Enhancing PET hydrolytic enzyme activity by fusion of the cellulose-binding domain of cellobiohydrolase I fromTrichoderma reesei. Journal of Biotechnology, 2021, 334, 47-50.
123. Dai, L.,#Qin L.,#Hu, Y., Huang, J. W., Hu, Z., Min, J., Sun, Y.,*,Guo, R.T.,* Structural dissection of unnatural ginsenoside-biosynthetic UDP-glycosyltransferase Bs-YjiC fromBacillus subtilisfor substratepromiscuity. Biochemical and Biophysical Research Communications, 2021, 534, 73-78.
122. Chen, C. C.,#Yu, X.,#Kuo, C.J.,#Min, J.,Chen, S.,Ma, L.,* Liu, K.,*Guo, R. T.* Overview of antiviral drug candidates targeting coronaviral 3C-like main proteases, The FEBS Journal, 2021. (Review, https://doi.org/10.1111/febs.15696)
121. Chen, C. C.,#Min, J.,#Zhang, L.,Yang, Y.,Yu, X.,*Guo, R. T.* Advanced understanding of electron transfer pathway of cytochromeP450s, ChemBioChem, 2021, 22, 1317-1328. (Review, Coverstory)
2020年：
120. Chen, C. C.,#Satish R. Malwal,#Han, X.,#Liu, W.,Ma, L.,Zhai, C.,Dai, L., Huang, J.W., Shillo Alli, Desai Janish, Ma,X., Zhang, Y., Guo, R.T.,*Oldfield, E.* Terpene cyclases and prenyltransferases: structures and mechanisms of action, ACS Catalysis, 2020, 11(1): 290-303.
119. Zhang, L.,#Xie, Z.,#Liu, Z.,#Zhou, S., Ma, L., Liu, W., Huang, J. W., Ko, T. P., Li, X., Hu, Y., Min, J., Yu, X.,Guo, R. T.,*Chen, C. C.*Structural Insight Into the Electron Transfer Pathway of a Self-Sufficient P450 Monooxygenase. Nature Communications, 2020, 11, 2676. (Highlighted by C&EN, ChemistryViews)
118. Chen, C. C.,* Zhang, L., Yu, X., Ma, L., Ko, T. P.,Guo, R. T.*Versatile cis-isoprenyl Diphosphate Synthase Superfamily Members in Catalyzing Carbon–Carbon Bond Formation. ACS Catalysis, 2020, 10, 4717-4725. (Review, ACS Editors’ Choice, Cover story)
117. Chen, C. C., Dai, L., Ma, L.,*Guo, R. T.*Enzymatic degradation of plant biomass and synthetic polymers.Nature Reviews Chemistry, 2020, 4, 114-126. (Review, Cover story)
116. Huang, J. W.,#Niu, D.,#Liu, K.,#Wang, Q., Ma, L., Chen, C. C., Zhang, L., Liu, W., Zhou, S., Min, J., Wu, S., Yang, Y.,*Guo, R. T.*Structure basis of non-structural protein pA151R from African Swine Fever Virus. Biochemical and Biophysical Research Communications, 2020, 532, 108-113.
115. Zhou,S., Ko,T.P.,*Huang,J.W., Liu,W., Zheng,Y., Wu,S., Wang,Q., Xie,Z., Liu,Z., Chen,C.C,*Guo,R.T*. Structure of a gut microbial diltiazem-metabolizing enzyme suggests possible substrate binding mode.Biochemical and Biophysical Research Communications, 2020, 527, 799-804.
114. Song, M., Zhang, X., Liu, W.,* Feng, J.,* Cui, Y., Yao, P., Wang, M.,Guo, R. T.,Wu, Q., Zhu, D.*2,3-Dihydroxybenzoic Acid Decarboxylase fromFusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism.ChemBioChem, 2020, 21,2950-2956.
113. Xiao, X., Elsayed, S. S., Wu, C., van der Heul, H. U., Metsä-Ketelä, M., Du, C., Prota, A. E., Chen, C. C., Liu, W.,Guo, R. T.,Abrahams, J. P., van Wezel, G. P.Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway., ACS Chemical Biology, 2020, 15(9):2529-2538.
112. Liu, Y., Lee, C., Li, F., Trček, J., Bähre, H.,Guo, R. T.,Chen, C. C., Chernobrovkin, A., Zubarev, R., Römling, U.* A Cyclic di-GMP Network Is Present in Gram-Positive Streptococcus andGram-Negative Proteus Species., ACS Infectious Diseases, 2020, 6(10):2672-2687.
2019年：
111. Chen, X.,#Zhang, H.,#Maria-S., Miguel A., Liu, W., Li, J., Feng, J., Liu, X., Osuna S.,Guo, R. T.,Wu, Q.,* Zhu, D.,* Ma, Y. Efficient reductive desymmetrization of bulky 1, 3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase, Nature Catalysis, 2019, 2, 931-941.
110. Yang, Y.,#Li, L.,#Yuan, L.,#Zhou, X.,#Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y., Oldfield, E.,Guo, R. T.,*Zhang, Y.* A Structural change in butyrophilin upon phosphoantigen binding underlies phosphoantigen-mediated Vgamma9Vdelta2 T cell activation. Immunity, 2019, 50, 1043-1053.
109. Sun, H.,#Ko, T. P.,#Liu, W., Liu, W., Zheng, Y., Chen, C. C.,*Guo, R. T.*Structure of an antibiotic-synthesizing UDP-glucuronate 4-epimerase MoeE5 in complex with substrate.Biochemical and Biophysical Research Communications, 2019, 521, 31-36.
108. Kuo, C. J., Gao, J., Huang, J. W., Ko, T. P., Zhai, C., Ma, L., Liu, W., Dai, L., Chang, Y. F., Chen, T. H., Hu, Y., Yu, X.,Guo, R. T.,*Chen, C. C.* Functional and structural investigations of fibronectin-binding protein Apa fromMycobacteriumtuberculosis. Biochimica et Biophysica Acta.General subjects, 2019, 1863,1351-1359.
107. Tang, X.#Xue, J.#, Yang, Y., Ko, T. P., Chen, C.Y., Dai, L.,Guo, R.T. ,Zhang, Y.,* Chen C. C.* Structural insights into the calcium dependence of Stig cyclases.RSC Advances, 2019, 9, 13182.
106. Yang, Z.,#Zhang, L.,#Yu, X., Wu, S., Yang, Y., Hu, Y., Li, Q., Shang, N.,Guo, R. T.,Chen, C. C., Dai, L.,* Liu, W.* Crystal structure of TchmY from Actinoplanes teichomyceticus.Acta Crystallographica Section F: Structural Biology Communications, 2019, 75: 570-575.
105. Feng, Y.,#Yu, X.,#Huang, J. W.,#Liu, W., Li, Q., Hu, Y., Yang, Y., Chen, Y., Jin, J., Li, H.,* Chen, C. C.,*Guo, R. T.*Crystal structure and proposed mechanism of an enantioselective hydroalkoxylation enzyme from Penicillium herquei. Biochemical and Biophysical Research Communications, 2019, (3): 801-805.
104. Ma, J.,#Ko, T. P.,#* Yu, X.,#Zhang, L., Ma, L., Zhai, C.,Guo, R. T.,Liu, W., Li, H., Chen, C. C.* Structural insights to heterodimericcis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1.Biochemical and Biophysical Research Communications, 2019, 515, 621-626.
103. Zhang, L.,#Ko, T. P.,#Malwal S. R., Liu W., Zhou S., Oldfield E.,Guo R. T.,*and Chen, C. C.*Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism,Biochemical and Biophysical Research Communications, 2019, 511, 800-805
102. Chang, Z.,#Ansbacher, T.,#Zhang, L.,#Yang, Y., Ko, T. P., Zhang, G., Liu, W., Huang, J. W., Dai, L.,Guo, R. T.,Major, D. T.,* Chen, C. C.* Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis,Organic Biomolecular Chemistry, 2019, 17, 2070-2076.(Cover story)
101. Malwal, S. R., Chen, L., Hicks, H., Qu, F., Liu, W., Shillo, A., Law, W.X., Zhang, J., Chandnani, N., Han, X., Zheng, Y., Chen, C. C.,Guo, R. T.,AbdelKhalek, A., Seleem, M. N., Oldfield, E.Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis. Journal of Medicinal Chemistry, 2019, 62, 2564-2581.
100. Zhang, M., Yu, X. W., Xu, Y., Guo, R. T., Swapna, GVT, Szyperski, T., Hunt, J. F., Montelione, G. T. Structural Basis by Which the N-Terminal Polypeptide Segment of Rhizopus chinensis Lipase Regulates Its Substrate Binding Affinity. Biochemistry, 2019, 58, 3943-3954.
2018年：
99. Chen, C. C.,#Hu, X.,#Tang, X.,#Yang, Y.,#Ko, T. P., Gao, J., Zheng, Y., Huang, J. W., Yu, Z., Li, L., Han, S., Cai, N., Zhang, Y.,* Liu, W.,*Guo, R. T.*The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement. Angewandte Chemie International Edition, 2018, 57, 15060-15064. (Cover story)
98. Gao, J.,#Ko, T. P.,#Chen, L.,#Malwal, S. R., Zhang, J., Hu, X., Qu, F., Liu, W., Huang, J. W., Cheng, Y. S., Chen, C. C., Yang, Y., Zhang, Y., Oldfield, E.,Guo, R. T.*“Head-to-Middle” and “Head-to-Tail”cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angewandte Chemie International Edition, 2018, 57, 683-687. (Cover story)
97. Chen, C. C.,#Han, X.,#Ko, T. P., Liu, W.,*Guo, R. T.*Structural studies reveal the molecular mechanism of PETase. FEBS Journal, 2018, 285, 3717-3723.
96. You, S., Chen, C. C., Tu, T., Wang, X., Ma, R., Cai, H. Y.,Guo, R. T.,*Luo, H. Y.,*Yao, B.*Insight into the functional roles of Glu175 in the hyperthermostable xylanase XYL10C-ΔN through structural analysis and site-saturation mutagenesis. Biotechnol Biofuels, 2018, 11, 159.
95. Zheng, Y.,#Liu, W.,#Chen C. C.,#Hu, X., Liu, W., Ko, T. P., Tang, X., Wei, H., Huang, J. W.,Guo, R. T.*Crystal Structure of a Mycoestrogen-Detoxifying Lactonase fromRhinocladiella mackenziei: Molecular Insight into ZHD Substrate Selectivity. ACS Catalysis, 2018, 8, 4294-4298.
94. Malwal, S. R.,#Gao, J.,#Hu, X.,#Yang, Y.,#Liu, W., Huang J. W., Ko, T. P., Li, L., Chen, C. C., O’Dowd, B., Khade, R. L., Zhang, Y., Zhang, Y., Oldfield, E.,Guo, R. T.*Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes. ACS Catalysis, 2018, 8, 4299-4312.
93. Lee, Suki Man-Yan,Yip, T.,Yan, S., Jin, D., Wei,H., Guo, R.T., Peiris, JS Malik,*Recognition of double-stranded RNA and regulation of interferon pathway by Toll-likereceptor10. Frontiers inImmunology, 2018, 9, 516.
92. Wang, J.,#Chen, C. C.,#Yang, Y.,#Liu, W., Ko, T. P., Shang, N., Hu, X., Xie, Y., Huang, J. W., Zhang, Y.,*Guo, R. T.*Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis. Biochemical and Biophysical Research Communications, 2018, 495, 1782-1788.
2017年：
91. Han, X.,#Liu, W.,#Huang, J. W.,#Ma, J., Zheng, Y., Ko, T. P., Xu, L., Cheng, Y. S., Chen, C. C., Guo, R. T.*Structural insight into catalytic mechanism of PET hydrolase. Nature Communications, 2017, 13, 2106.
90. Gao, J.,#Huang, J. W.,#Li, Q.,#Liu, W., Ko, T. P., Zheng, Y., Xiao, X., Kuo, C. J., Chen, C. C.,*Guo, R. T.*Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-β-endoglucanase from Thielavia terrestris. Enzyme and Microbial Technology, 2017, 99, 32-37.
89. Schwalen, C. J., Feng, X., Liu, W., O-Dowd, B., Ko, T. P., Shin, C. J., Guo, R. T., Mitchell, D. A.,* Oldfield, E.* Head-to-Head Prenyl Synthases in Pathogenic Bacteria. ChemBioChem : a European Journal of Chemical Biology, 2017, 18, 985-991.
88. Hui, R.,#Hu, X.,#Liu, W., Zheng, Y., Chen, Y., Guo, R. T., Jin, J.,*Chen, C. C.*Characterization and crystal structure of a novel zearalenone hydrolase fromCladophialophora bantiana. Acta Crystallographica. Section F, Structural Biology Communications, 2017, 73, 515-519.
2016年：
87. Zhang, L.,#Chen, C. C.,#Ko, T. P.,#Huang, J. W., Zheng, Y., Liu, W., Wang, I., Malwal, S. R., Feng, X., Wang, K., Huang, C. C., Hsu, S. T., Wang, A. H., Oldfield, E.,* and Guo, R. T.*Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyl Transferase MoeN5, Angewandte Chemie International Edition, 2016, 55, 4716-4720.
86. Xu, Z.,#Liu, W.,#Chen, C. C.,#Li Q., Huang, J. W., Ko, T. P., Liu, G., Liu, W., Peng, W., Cheng, Y. S., Chen, Y., Jin, J., Li, H.,* Zheng, Y.,*Guo, R. T.*Enhanced α‑Zearalenol Hydrolyzing Activity of a Mycoestrogen Detoxifying Lactonase by Structure-Based Engineering. ACS Catalysis, 2016, 6, 7657-7663. (Cover story)
85. Liu, M.,#Chen, C. C.,#Chen, Lu.,#Xiao, X., Zheng, Y.,Huang, J. W., Liu, W., Ko, T. P., Cheng, Y. S., Feng, X., Oldfield, E.,*Guo, R. T.,*and Ma, Y.* Structure and Function of a “Head-to-Middle” Prenyltransferase: Lavandulyl Diphosphate Synthase, Angewandte Chemie International Edition,2016, 55, 4721-4724. (Cover story)
84. Wang, Y., Desai, J., Zhang, Y., Malwal, S. R., Shin, C. J., Feng, X., Sun, H., Liu, G., Guo, R. T., Oldfield, E.* Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase. ChemMedChem, 2016, 11, 2311-2319.
83. Yan, J.,#Liu, W.,#Li, Y., Lai, H. L., Zheng, Y., Huang, J. W., Chen, C. C., Chen, Y., Jin, J., Li, H.,*Guo, R. T.*Functional and structural analysis of Pichia pastoris-expressedAspergillus niger1,4-β-endoglucanase. Biochemical and Biophysical Research Communications, 2016, 17, 8-12.
82. Desai, J., Liu, Y. L., Wei, H., Liu, W., Ko, T. P., Guo, R. T., Oldfield, E.*Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase. ChemMedChem, 2016, 11, 1915-1923.
81. Huang, J. W.,#Liu, W.,#Lai, H. L., Cheng, Y. S., Zheng, Y., Li, Q., Sun, H., Kuo, C. J., Guo, R. T.,*Chen, C. C.*Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50. Biochemical and Biophysical Research Communications, 2016, 16, 565-572.
80. Yang, Y.,#Ko, T. P.,#Chen, C. C.,#Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M., Hsu, S., O'Dowd, B., Huff, H., Huang, C. H., Docampo, R., Oldfield, E.,*Guo, R. T.,*Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Anti-Parasitic Drug Targets. ACS Chemical Biology, 2016, 11, 1362-1371.
79. Zheng, Y.,#Li, Y.,#Liu, W.#, Chen, C. C., Ko, T. P., He, M., Xu, Z., Liu, M., Luo, H.,Guo, R. T.,*Yao B,* and Ma Y.* Structural insight into potential cold adaptation mechanism through a psychrophilic glycoside hydrolase family 10 endo-β-1, 4-xylanase. Journal of Structural Biology, 2016, 193, 206-211. (Cover story)
78. Liu, G., Li, Q., Shang, N., Huang J. W., Ko, T. P., Liu, W., Zheng, Y., Han, X., Chen, Y., Chen, C. C., Jin, J., and Guo, R. T.*Functional and structural analyses of a 1,4- β-endoglucanase fromGanoderma lucidum, Enzyme and Microbial Technology, 2016, 86, 67-74.
2015年：
77. Hu, Y.,#Liu, W.,#Malwal, S. R.,Zheng, Y., Feng, X., Ko, T. P., Chen, C. C., Xu, Z., Liu, M., Han, X., Gao, J., Oldfield, E.,* and Guo, R. T.*Structures of Iridoid Synthase from Cantharanthus roseuswith Bound NAD(+), NADPH, or NAD(+) /10-Oxogeranial: Reaction Mechanisms, Angewandte Chemie International Edition, 2015, 54, 15478-15482. (Cover story)
76. Cheng, Y. S., Chen, C. C., Huang, J. W., Ko, T. P., Huang, Z., and Guo, R. T.*Improving the catalytic performance of a GH11 xylanase by rational protein engineering, Applied Microbiology and Biotechnology, 2015, 99, 9503-9510.
75. Zheng, Y., Chen, C. C., Ko, T. P., Xiao, X., Yang, Y., Huang, C. H., Qian, G., Shao, W.,* and Guo, R. T.*Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacteriumThermotoga maritima, Journal of Structural Biology, 2015, 190, 135-142. (Cover story)
74. Guo, R. T.* Green Enzymes, ChemBioEng Reviews, 2015, 2, 75. (Invited Editorial)
73. Chen, C. C., Cheng, K. J., Ko, T. P., andGuo, R. T.*Current progresses in phytase research: Three-DimensionalStructure and Protein Engineering,ChemBioEng Reviews, 2015, 2, 76-86.(Cover story)
72. Chen, C. C., Ko, T. P., Huang, J. W., and Guo, R. T.*Heat- andalkaline-stable xylanases: applications, protein structure and engineering, ChemBioEng Reviews, 2015, 2, 95-106.
71. Chan, H. C.,#Ko, T. P.,#Huang, C. H., and Guo, R. T.*Minireview: A comeback of Hg-derivatives in protein crystallographywith Cys-modification, ChemBioEng Reviews, 2015, 2, 133-140.
70. Liu, W., Guo, R. T., Chen, X., Li, Z., Gao, X., Huang, C. H., Wu, Q., Feng, J., and Zhu,D.* Structural Analysis Reveals the Substrate-Binding Mechanism for the Expanded Substrate Specificity of Mutantmeso-Diaminopimelate Dehydrogenase, ChemBioChem: a European Journal of Chemical Biology, 2015, 16, 924-929. (Cover story)
69. Chen,Y., Huang, J. W., Chen, C. C., Lai, H. L., Jin, J., and Guo, R. T.*Crystallization and preliminary X-ray diffraction analysis of an endo-1, 4-beta-D-glucanase fromAspergillus aculeatusF-50, Acta Crystallographica. Section F, Structural Biology Communications, 2015, 71, 397-400.
68. Zhu, W., Wang, Y., Li, K., Gao, J., Huang, C. H., Chen, C. C., Ko, T. P., Zhang, Y., Guo, R.T., and Oldfield, E.* Antibacterial Drug Leads: DNA and Enzyme Multi-Targeting, Journal of Medicinal Chemistry, 2015,58, 1215-1227.
67. Zheng, Y.,#Ko, T. P.,#Yang, Y., Shao, W.,* and Guo, R. T.,*Binding mode of the oxidized alpha-anomer of NAD+to RSP, a Rex-family repressor, Biochemical and Biophysical Research Communications, 2015, 456, 733-736.
66. Yuan, S. F., Wu, T. H., Lee, H. L., Hsieh, H. Y., Lin, W. L., Yang, B., Chang, C. K., Li, Q., Gao, J., Huang, C. H., Ho, M. C.,*Guo, R.T.,*and Liang, P. H.* Biochemical characterization and structural analysis of a bi-functional cellulase/xylanase from Clostridium thermocellum, The Journal of Biological Chemistry, 2015, 290, 5739-5748.
65. Chen, C. C., Huang, J. W., Zhao, P., Ko, T. P., Huang, C. H., Chan, H. C., Huang, Z., Liu, W., Cheng, Y. S., Liu, J. R., and Guo, R. T.*Structural analyses and yeast production of the β-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum, Enzyme and Microbial Technology, 2015, 71, 1-7.
64. Veiga-Santos, P., Li, K., Lameira, L., de Carvalho, T. M., Huang, G., Galizzi, M., Shang, N., Li, Q., Gonzalez-Pacanowska, D., Hernandez-Rodriguez, V., Benaim, G., Guo, R. T., Urbina, J. A., Docampo, R., de Souza, W., and Oldfield, E.* SQ109: A New Drug Lead for Chagas Disease, Antimicrobial Agents and Chemotherapy, 2015, 59, 1950-1961.
63. Han, X., Chen, C. C., Kuo, C. J., Huang, C. H., Zheng, Y., Ko, T. P., Zhu, Z., Feng, X., Wang, K., Oldfield, E., Wang, A. H., Liang, P. H., Guo, R. T.,*and Ma, Y.* Crystal structures of ligand-bound octaprenyl pyrophosphate synthase fromEscherichia colireveal the catalytic and chain-length determining mechanisms, Proteins, 2015, 83, 37-45.
2014年：
62. Chan, H. C.,#Feng, X.,#Ko, T. P.#, Huang, C. H., Hu, Y., Zheng, Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D. C., Liang, P. H., Wang, A. H., Oldfield, E.,* andGuo, R. T.*Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase fromMycobacterium tuberculosis, Journal of the American Chemical Society, 2014, 136, 2892-2896.
61. Liu, W.,#Feng, X.,#Zheng, Y.,#Huang, C. H., Nakano, C., Hoshino, T., Bogue, S., Ko, T. P., Chen, C. C., Cui, Y., Li, J., Wang, I., Hsu, S. T., Oldfield, E.,* and Guo, R. T.*Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum, Scientific Reports, 2014, 4, 6214.
60. Cheng, Y. S.,#Chen, C. C.,#Huang, C. H., Ko, T. P., Luo, W., Huang, J. W., Liu, J. R., and Guo, R. T.*Structural analysis of a glycoside hydrolase family 11 xylanase fromNeocallimastix patriciarum: insights into the molecular basis of a thermophilic enzyme, The Journal of Biological Chemistry, 2014, 289, 11020-11028.
59. Shang, N.,#Li, Q.,#Ko, T. P.,#Chan, H. C., Li, J., Zheng, Y., Huang, C. H., Ren, F., Chen, C. C., Zhu, Z., Galizzi, M., Li, Z. H., Rodrigues-Poveda, C. A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T. M., de Souza, W., Urbina, J. A., Wang, A. H., Docampo, R., Li, K., Liu, Y. L., Oldfield, E.,* and Guo, R. T.*Squalene synthase as a target for Chagas disease therapeutics, PLoS Pathogens, 2014, 10, e1004114.
58. Zheng, Y.,#Ko, T. P.,#Sun, H., Huang, C. H., Pei, J., Qiu, R., Wang, A. H., Wiegel, J., Shao, W.,* and Guo, R. T.*Distinct structural features of Rex-family repressors to sense redox levels in anaerobes and aerobes, Journal of Structural Biology, 2014, 188, 195-204. (Cover story)
57. Peng, W.,#Ko, T. P.,#Yang, Y., Zheng, Y., Chen, C. C., Zhu, Z., Huang, C. H., Zeng, Y. F., Huang, J. W., Wang, A. H.-J., Liu, J. R.,* and Guo, R. T.*Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea, RSC Advances, 2014, 4, 62321-62325.
56. Zhu, Z.,#He, M.,#Huang, C. H., Ko, T. P., Zeng, Y. F., Huang, Y. N., Jia, S., Lu, F., Liu, J. R., and Guo, R. T.*Crystallization and preliminary X-ray diffraction analysis of a novel beta-L-arabinofuranosidase (HypBA1) from Bifidobacterium longum, Acta Crystallographica. Section F, StructuralBiology Communications, 2014, 70, 636-638.
55. Huang, C. H., Zhu, Z., Cheng, Y.S., Chan, H.C., Ko, T.P., Chen, C. C., Wang, I., Ho, M. R., Hsu, S. T. -D., Zeng, Y. F., Huang, Y. N., Liu, J. R.,* and Guo, R. T.*Structure and Catalytic Mechanism of a Glycoside Hydrolase Family-127β-L-Arabinofuranosidase (HypBA1). J Bioprocess Biotech, 2014, 4, 171.
54. Zhang, L.,#Zhao, P.,#Chen, C. C., Huang, C. H., Ko, T. P., Zheng, Y., and Guo, R. T.*Preliminary X-ray diffraction analysis of a thermophilic beta-1,3-1,4-glucanase fromClostridium thermocellum, ActaCrystallographica. Section F, Structural Biology Communications, 2014, 70, 946-948.
53. Yang, Y.,#Ko, T. P.,#Liu, L., Li, J., Huang, C. H., Chen, J., Guo, R. T.,*and Du, G.* Roles of tryptophan residue and disulfide bond in the variable lid region of oxidized polyvinyl alcohol hydrolase, Biochemical and Biophysical Research Communications, 2014,452, 509-514.
52. Yang, Y.,#Ko, T. P.,#Liu, L., Li, J., Huang, C. H., Chan, H. C., Ren, F., Jia, D., Wang, A. H., Guo, R. T.,*Chen, J.,* and Du, G.* Structural insights into enzymatic degradation of oxidized polyvinyl alcohol, ChemBioChem: a European Journal of ChemicalBiology, 2014, 15, 1882-1886. (Cover story)
51. Xu, J.,#Ren, F.,#Huang, C. H., Zheng, Y., Zhen, J., Sun, H., Ko, T. P., He, M., Chen, C. C., Chan, H. C.,Guo, R. T.,*Song, H.,* and Ma, Y.* Functional and structural studies of pullulanase from Anoxybacillussp. LM18-11, Proteins, 2014,82, 1685-1693. (Cover story)
50. Wu, T. H.,#Chen, C. C.,#Cheng, Y. S., Ko, T. P., Lin, C. Y., Lai, H. L., Huang, T. Y., Liu, J.R., * and Guo, R. T.*Improving specific activity and thermostability of Escherichia coliphytase by structure-based rational design, Journal of Biotechnology, 2014, 175, 1-6.
49. Wang, S., Nie, Y., Xu, Y.,* Ko, T. P., Huang, C. H., Chan, H. C., Guo, R.T.,*and Xiao, R. Crystallization and preliminary X-ray diffraction analysis of (R)-carbonyl reductase fromCandida parapsilosis, ActaCrystallographica. Section F, Structural Biology Communications, 2014, 70, 800-802.
48. Wang, S., Nie, Y., Xu, Y.,* Zhang, R., Ko, T. P., Huang, C. H., Chan, H. C., Guo, R. T.,*and Xiao, R. Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase, Chemical Communications, 2014, 50, 7770-7772. (Cover story)
47. Tseng, C. W.,#Liao, C. Y.,#Sun, Y., Peng, C. C., Tzen, J. T., Guo, R.T.,*and Liu, J. R.* Immobilization ofClostridium cellulolyticum D-psicose 3-epimerase on artificial oil bodies, Journal of Agricultural and Food Chemistry, 2014, 62, 6771-6776.
46. Lv, P.,#Zhang, L.,#Luo, H., Chen, C. C., Huang, C. H., Peng, W., Wang, K., Ko, T. P., Zheng, Y., Zhang, J., Yao, B.,* and Guo, R. T.*Preliminary X-ray diffraction analysis of thermostable beta-1,4-xylanase from Streptomycessp. S9, ActaCrystallographica. Section F, Structural Biology Communications, 2014, 70, 105-107.
45. Liu, W., Li, Z., Huang, C. H., Guo, R. T., Zhao, L., Zhang, D., Chen, X., Wu, Q., and Zhu, D.* Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum, ChemBioChem: a European Journal of ChemicalBiology, 2014, 15, 217-222. (Cover story)
44. Li, K., Schurig-Briccio, L. A., Feng, X., Upadhyay, A., Pujari, V., Lechartier, B., Fontes, F. L., Yang, H., Rao, G., Zhu, W., Gulati, A., No, J. H., Cintra, G., Bogue, S., Liu, Y. L., Molohon, K., Orlean, P., Mitchell, D. A., Freitas-Junior, L., Ren, F., Sun, H., Jiang, T., Li, Y.,Guo, R. T., Cole, S. T., Gennis, R. B., Crick, D. C., and Oldfield, E.* Multitarget drug discovery for tuberculosis and other infectious diseases, Journal of Medicinal Chemistry, 2014, 57, 3126-3139.
43. Huang, J. W.,#Chen, C. C.,#Huang, C. H., Huang, T. Y., Wu, T. H., Cheng, Y. S., Ko, T. P., Lin, C. Y., Liu, J.R.,* and Guo, R. T.,*Improving the specific activity of beta-mannanase from Aspergillus niger BK01 by structure-based rational design, Biochimica et BiophysicaActa, 2014, 1844, 663-669. (Cover story)
42. He, M.,#Zheng, Y.,#Huang, C. H., Qian, G., Xiao, X., Ko, T. P., Shao, W., and Guo, R. T.*Crystallization and preliminary X-ray diffraction analysis of the S-adenosylhomocysteine hydrolase (SAHH) from Thermotoga maritima, ActaCrystallographica. Section F, Structural Biology Communications, 2014, 70, 1563-1565.
41. Feng, X.,#Hu, Y.,#Zheng, Y.,#Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., Lopez, D., Kolter, R., Gotz, F., Guo, R. T.,* and Oldfield, E.* Structural and Functional Analysis of Bacillus subtilisYisP Reveals a Role of Its Product in Biofilm Production, Chemistry &Biology, 2014, 21, 1557-1563.
40. Cheng, Y. S.,#Huang, C. H.,#Chen, C. C., Huang, T. Y., Ko, T. P., Huang, J. W., Wu, T. H., Liu, J.R.,* and Guo, R. T.,*Structural and mutagenetic analyses of a 1,3-1,4-beta-glucanase from Paecilomyces thermophila, Biochimica et BiophysicaActa, 2014, 1844, 366-373. (Cover story)
39. Chen, C. C.,#Luo, H.,#Han, X.,#Lv, P., Ko, T. P., Peng, W., Huang, C. H., Wang, K., Gao, J., Zheng, Y., Yang, Y., Zhang, J., Yao, B.,* and Guo, R. T.*Structural perspectives of an engineered beta-1,4-xylanase with enhanced thermostability, Journal of Biotechnology, 2014, 189, 175-182.
38. Bai, W., Zhou, C., Xue, Y., Huang, C. H., Guo, R.T., and Ma, Y.* Three-dimensional structure of an alkaline xylanase Xyn11A-LC from alkalophilic Bacillussp. SN5 and improvement of its thermal performance by introducing arginines substitutions, Biotechnology Letters, 2014, 36, 1495-1501.
2013年：
37. Ren, F.,#Feng, X.,#Ko, T. P.,#Huang, C. H., Hu, Y., Chan, H. C., Liu, Y. L., Wang, K., Chen, C. C., Pang, X., He, M., Li, Y., Oldfield, E.,* and Guo, R. T.*Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus, ChemBioChem: a European Journal of Chemical Biology, 2013, 14, 195-199. (Cover story)
36. Luo, W.,#Huang, J. W.,#Huang, C. H., Huang, T. Y., Chan, H. C., Liu, J. R., Guo, R. T., and Chen, C. C.* Preliminary X-ray diffraction analysis of thermostable beta-1,4-mannanase from Aspergillus niger BK01, ActaCrystallographica. Section F, Structural Biology and Crystallization Communications, 2013, 69, 1100-1102.
35. Li, X.,#Han, X.,#Ko, T. P., Chen, C. C., Zhu, Z., Hua, E.,Guo, R. T.,and Huang, C. H. * Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase from Escherichia coli, Acta crystallographica. Section F, Structural Biology and Crystallization Communications, 2013, 69, 328-331.
34. Jiang, T.,#Chan, H. C.,#Huang, C. H., Ko, T. P., Huang, T. Y., Liu, J.R., andGuo, R. T.*Substrate binding to a GH131 beta-glucanase catalytic domain from Podospora anserina, Biochemical and Biophysical Research Communications, 2013, 438, 193-197.
33. Hu, Y., Jia, S., Ren, F., Huang, C. H., Ko, T. P., Mitchell, D. A., Guo, R. T., and Zheng, Y. * Crystallization and preliminary X-ray diffraction analysis of YisP protein fromBacillus subtilissubsp. subtilis strain 168, ActaCrystallographica. Section F, Structural Biology and Crystallization Communications, 2013, 69, 77-79.
32. Han, X.,#Gao, J.,#Shang, N.,#Huang, C. H., Ko, T. P., Chen, C. C., Chan, H. C., Cheng, Y. S., Zhu, Z., Wiegel, J., Luo, W.,*Guo, R. T.,*and Ma, Y.* Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485, Proteins, 2013, 81, 1256-1265. (Cover story)
31. Chang, T. H.,#Chang, S. J.,#Hsieh, F. L., Ko, T. P., Lin, C. T., Ho, M. R., Wang, I., Hsu, S. T., Guo, R. T., Chang, W., and Wang, A. H.* Crystal structure of vaccinia viral A27 protein reveals a novel structure critical for its function and complex formation with A26 protein, PLoS Pathogens, 2013,9, e1003563.
2012年：
30. Ren, F.,#Ko, T. P.,#Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H., Oldfield, E.,* and Guo, R. T.*Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes, Angewandte Chemie International Edition, 2012, 51, 4157-4160. (Cover story)
29. Zheng, Y., Huang, C. H., Liu, W., Ko, T. P., Xue, Y., Zhou, C., Guo, R.T., and Ma, Y.* Crystal structure and substrate-binding mode of a novel pectate lyase from alkaliphilicBacillussp. N16-5, Biochemical and Biophysical Research Communications, 2012, 420, 269-274.
28. Liu, W., Sun, Y., Ko, T. P., Wiegel, J., Shao, W., Lu, F., Guo, R. T., and Huang, C. H.* Crystallization and preliminary X-ray diffraction analysis of a novel GH120 beta-xylosidase (XylC) fromThermoanaerobacterium saccharolyticumJW/SL-YS485, ActaCrystallographica. Section F, StructuralBiology and Crystallization Communications, 2012, 68, 914-916.
27. Huang, J. W., Cheng, Y. S., Ko, T. P., Lin, C. Y., Lai, H. L., Chen, C. C., Ma, Y., Zheng, Y., Huang, C. H., Zou, P., Liu, J.R.,* and Guo, R. T.*Rational design to improve thermostability and specific activity of the truncated Fibrobacter succinogenes1,3-1,4-beta-D-glucanase, Applied Microbiology and Biotechnology, 2012, 94, 111-121.
26. Huang, C. H.,#Sun, Y.,#Ko, T. P., Chen, C. C., Zheng, Y., Chan, H. C., Pang, X., Wiegel, J.,* Shao, W.,* and Guo, R. T.*The substrate/product-binding modes of a novel GH120 beta-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485, The Biochemical Journal, 2012, 448, 401-407.
25. Cheng, Y. S., Ko, T. P., Huang, J. W., Wu, T. H., Lin, C. Y., Luo, W., Li, Q., Ma, Y., Huang, C. H., Wang, A. H., Liu, J.R.,* and Guo, R. T.*Enhanced activity of Thermotoga maritimacellulase 12A by mutating a unique surface loop, Applied Microbiology and Biotechnology, 2012, 95, 661-669.
24. Chang, K. M., Chen, S. H., Kuo, C. J., Chang, C. K.,Guo, R. T.,Yang, J.M., and Liang, P. H.* Roles of amino acids in the Escherichia colioctaprenyl diphosphate synthase active site probed by structure-guided site-directed mutagenesis, Biochemistry, 2012,51, 3412-3419.
23. Chan, H. C.,#Zhu, Y.,#Hu, Y., Ko, T. P., Huang, C. H., Ren, F., Chen, C. C., Ma, Y., Guo, R. T.,*and Sun, Y.* Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticumH10 and its complex with ketohexose sugars, Protein &Cell, 2012, 3, 123-131. (Cover story)
22. Pai, C.K.Wang, H.T., Guo, R.T., and Liu, J.R.*The construction of bifunctional fusion xylanolyticenzymes and the prediction of optimum reaction conditions for the enzyme activity, BioResources, 2012, 7, 5647-5665.
2011年：
21. Zeng, Y. F.,#Ko, T. P.,#Lai, H. L., Cheng, Y. S., Wu, T. H., Ma, Y., Chen, C. C., Yang, C. S., Cheng, K. J., Huang, C. H., Guo, R. T.,*and Liu, J. R.* Crystal structures of Bacillusalkaline phytase in complex with divalent metal ions and inositol hexasulfate, Journal of Molecular Biology, 2011, 409, 214-224. (Cover story)
20. Wu, T. H.,#Huang, C. H.,#Ko, T. P., Lai, H. L., Ma, Y., Chen, C. C., Cheng, Y. S., Liu, J. R.,* and Guo, R. T.*Diverse substrate recognition mechanism revealed by Thermotoga maritima Cel5A structures in complex with cellotetraose, cellobiose and mannotriose, Biochimica etBiophysicaActa, 2011, 1814, 1832-1840. (Cover story)
19. Tseng, C. W.,#Ko, T. P.,#Guo, R. T.,#Huang, J. W., Wang, H. C., Huang, C. H., Cheng, Y. S., Wang, A. H., and Liu, J. R.* Substrate binding of a GH5 endoglucanase from the ruminal fungusPiromyces rhizinflata, Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 2011, 67, 1189-1194. (Cover story)
18. Cheng, Y. S., Ko, T. P., Wu, T. H., Ma, Y., Huang, C. H., Lai, H. L., Wang, A. H., Liu, J. R.,* and Guo, R. T.*Crystal structure and substrate-binding mode of cellulase 12A fromThermotoga maritima, Proteins, 2011, 79, 1193-1204.(Cover story)
博士及博士后期间工作：
17. Zhang, Y., Cao, R., Yin, F., Hudock, M. P.,Guo, R. T.,Krysiak, K., Mukherjee, S., Gao, Y. G., Robinson, H., Song, Y., No, J. H., Bergan, K., Leon, A., Cass, L., Goddard, A., Chang, T. K., Lin, F. Y., Van Beek, E., Papapoulos, S., Wang, A. H., Kubo, T., Ochi, M., Mukkamala, D., and Oldfield, E.* Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation, Journal of the American Chemical Society, 2009, 131, 5153-5162.
16. Guo, R. T.,#Chong, Y. E.,#Guo, M., and Yang, X. L.* Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis, The Journal of Biological Chemistry, 2009, 284, 28968-28976.
15. Chen, C. K., Lee, G. C., Ko, T. P.,Guo, R. T.,Huang, L. M., Liu, H. J., Ho, Y. F., Shaw, J.F., and Wang, A. H.* Structure of the alkalohyperthermophilic Archaeoglobus fulgiduslipase contains a unique C-terminal domain essential for long-chain substrate binding, Journal of Molecular Biology, 2009, 390, 672-685.
14. Wu, Y. H., Ko, T. P., Guo, R. T., Hu, S. M., Chuang, L.M., and Wang, A. H.* Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2, Structure, 2008, 16, 1714-1723.
13. Kuo, C. J.,Guo, R. T.,Lu, I. L., Liu, H. G., Wu, S. Y., Ko, T. P., Wang, A.H., and Liang, P. H.* Structure-based inhibitors exhibit differential activities againstHelicobacter pyloriandEscherichia coliundecaprenyl pyrophosphate synthases, Journal of Biomedicine &Biotechnology, 2008, 841312.
12. Jeng, W. Y., Ko, T. P., Liu, C. I.,Guo, R. T.,Liu, C. L., Shr, H.L., and Wang, A. H.* Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation inStaphylococcus epidermidis, Nucleic Acids Research, 2008, 36, 1567-1577.
11. Cao, R., Chen, C. K.,Guo, R. T.,Wang, A. H.,* and Oldfield, E. Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases, Proteins, 2008, 73, 431-439.
10. C, K. M. C., Hudock, M. P., Zhang, Y.,Guo, R. T.,Cao, R., No, J. H., Liang, P. H., Ko, T. P., Chang, T. H., Chang, S. C., Song, Y., Axelson, J., Kumar, A., Wang, A.H., and Oldfield, E.* Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation, Journal of Medicinal Chemistry, 2008, 51, 5594-5607.
9. Guo, R. T.,#Cao, R.,#Liang, P. H., Ko, T. P., Chang, T. H., Hudock, M. P., Jeng, W. Y., Chen, C. K., Zhang, Y., Song, Y., Kuo, C. J., Yin, F., Oldfield, E., and Wang, A. H.* Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases, Proceedings of the National Academy of Sciences of the United States of America, 2007, 104, 10022-10027.
8. Chang, T. H., Guo, R. T., Ko, T. P., Wang, A.H., and Liang, P. H.* Crystal structure of type-III geranylgeranyl pyrophosphate synthase fromSaccharomyces cerevisiaeand the mechanism of product chain length determination, The Journal of Biological Chemistry, 2006, 281, 14991-15000.
7. Sun, H. Y., Ko, T. P., Kuo, C. J., Guo, R. T., Chou, C. C., Liang, P.H., and Wang, A. H.* Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricusdisplays asymmetric subunit structures, Journal of Bacteriology, 2005, 187, 8137-8148.
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