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胡玉梅

作者:  发布时间:2023-02-10  阅读次数:

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一、基本信息

胡玉梅,博士,讲师,硕士研究生导师

电子邮件:huyumei@hubu.edu.cn

研究方向:生物催化与酶工程、酶分子改造、酶结构及催化机制解析

二、教育经历

2017.092020.06  天津科技大学,博士

2010.092013.03  天津科技大学,硕士

2011.032013.03  中科院天津工业生物技术研究所,联培硕士

2006.092010.06  中北大学,生物工程,学士

三、工作经历

2022.06至今           湖北大学生命科学学院,讲师

2020.062022.05  湖北大学生命科学学院,博士后

2013.042017.08  中科院天津工业生物技术研究所,助理研究员

四、科研项目

1. 国家自然科学基金青年基金(31600638),19万,20172019,主持

2. 中国博士后基金面上项目(2020M682381),8万,20202022,主持

3. 湖北省博士后创新研究岗(080090457),6万,20202022,主持

五、代表性论文#并列一作,*通讯作者

1. Hu, Y.,# Li, H.,# Min, J.,# Yu, Y., Liu, W., Huang J. W., Zhang, L., Yang, Y., Dai, L.,* Chen, C. C.,* Guo, R. T.* Crystal structure and biochemical analysis of the specialized deoxynivalenol–detoxifying glyoxalase SPG from Gossypium hirsutum. International Journal of Biological Macromolecules, 2022, 200, 388-396.(一区,TOP期刊,IF8.025

2. Li, H.,# Yang, Y.,# Hu, Y.,# Chen, C. C., Huang J. W., Min, J., Dai, L.,* Guo, R. T.* Structural analysis and engineering of aldo-keto reductase from glyphosate-resistant Echinochloa colona. Journal of Hazardous Materials2022. DOI:https://doi.org/10.1016/j.jhazmat.2022.129191 (一区IF14.224)

3. Dai, L.,# Li, H.,# Huang J. W., Hu, Y.,# He, M., Yang, Y., Min, J., Guo, R. T.,* Chen, C. C.* Structure-based rational design of a short-chain dehydrogenase/reductase for improving activity toward mycotoxin patulin. International Journal of Biological Macromolecules, 2022, 222, 421-428.(一区,TOP期刊,IF8.025

4. Dai, L.,# Zhang X.,# Hu Y.,# Shen J., Zhang Q.,Zhang L., Min J., Chen, C. C., Liu Y.,* Huang J. W.,* Guo, R. T.* Structural and functional insights into a nonheme iron- and α-ketoglutarate-dependent halogenase that catalyzes chlorination of nucleotide substrates. Applied and Environmental Microbiology, 2022. (TOP期刊,封面文章,IF5.005

5. Dai, L.,# Qu, Y.,# Hu, Y.,# Min, J., Yu, X., Chen, C., Huang, J. W.,* Guo, R. T.* Catalytically inactive lytic polysaccharide monooxygenase PcAA14A enhances the enzyme-mediated hydrolysis of polyethylene terephthalate. International Journal of Biological Macromolecules, 2021, 190, 456-462.(一区,TOP期刊,IF8.025

6. Hu, Y., Li H., Qu Y., Zhang, X., Zhang J., Dai, L.* Biocatalytic synthesis of a novel bioactive ginsenoside using UDP-glycosyltransferase from Bacillus Subtilis 168. Catalysts, 2020, 10289.IF 4.501

7. Hu, Y.,# Min, J.,# Qu, Y.; Zhang, X., Zhang, J., Yu, X.,* Dai, L.* Biocatalytic synthesis of calycosin-7-O-β-D-glucoside with UDP-glucose regeneration system. Catalysts, 2020, 10258.IF 4.501

8. Hu, Y.,# Xue, J.,# Min, J.,# Qin, L., Zhang, J.,* Dai, L.* Biocatalytic synthesis of ginsenoside Rh2 using Arabidopsis thaliana glucosyltransferase-catalyzed coupled reactions. Journal of Biotechnology, 2020, 309107-112.IF3.595

9. Hu, Y.,# Liu, W.,# Malwal, S. R.,Zheng, Y., Feng, X., Ko, T. P., Chen, C. C., Xu, Z., Liu, M., Han, X., Gao, J., Oldfield, E.,* Guo, R. T.* Structures of iridoid synthase from Cantharanthus roseus with bound NAD(+), NADPH, or NAD(+) /10-oxogeranialreaction mechanisms. Angewandte Chemie International Edition, 2015, 54, 15478-15482. (一区,IF16.823, VIP封面文章)

10. Feng, X.,# Hu, Y.,# Zheng, Y.,# Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., Lopez, D., Kolter, R., Gotz, F., Guo, R. T.,* Oldfield, E.* Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production. Cell Chemical Biology, 2014, 21, 1557-1563.(一区,IF9.039

11. Chan, H. C.,# Feng, X.,# Ko, T. P.#, Huang, C. H., Hu, Y., Zheng, Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D. C., Liang, P. H., Wang, A. H. J., Oldfield, E.,* Guo, R. T.* Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. Journal of the American Chemical Society, 2014, 136, 2892-2896. (一区,IF16.383

12. Hu, Y., Jia, S., Ren, F., Huang, C. H., Ko, T. P., Mitchell, D. A., Guo, R. T., Zheng, Y. * Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 2013, 69, 77-79.IF1.072

13. Ren, F.,# Feng, X.,# Ko, T. P.,# Huang, C. H., Hu, Y., Chan, H. C., Liu, Y. L., Wang, K., Chen, C. C., Pang, X., He, M., Li, Y., Oldfield, E.,* Guo, R. T.* Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus. ChemBioChem : a European Journal of Chemical Biology, 2013, 14, 195-199. (IF3.461封面文章)

14. Ren, F.,# Ko, T. P.,# Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H. J., Oldfield, E.,* Guo, R. T.* Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes. Angewandte Chemie International Edition, 2012, 51, 4157-4160. (一区,IF16.823,封面文章)

15. Chan, H. C.,# Zhu, Y.,# Hu, Y., Ko, T. P., Huang, C. H., Ren, F., Chen, C. C., Ma, Y., Guo, R. T.,* Sun, Y.* Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars. Protein & Cell, 2012, 3, 123-131. (一区,IF15.328,封面文章)

 

六、申请与授权专利

1. 陈纯琪,屈莹莹,戴隆海,黃建文,刘珂,张丽兰,杨云云,胡玉梅,詹志春,郭瑞庭,具纤维素结合域的PET水解酶,202010986920.0

七、获奖与荣誉称号

1. 2020年,天津市自然科学二等奖

 

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