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李爱涛

作者:  发布时间:2024-02-24  阅读次数:

http://weblg.hubu.edu.cn:8080/_vsl/DD1FA4586D89A8340BB077ADF69E7CF3/800D21E2/730A

一、基本信息

李爱涛,博士,教授,博导,省部共建生物催化与酶工程国家重点实验室副主任

电子邮箱:aitaoli(at)hubu.edu.cn; aitaoli(at)163.com

学术兼职:《Bioresources and Bioprocessing》和《Biodesign Research》副主编,Green Synthesis and Catalysis》、《Bioresources and Bioprocessing》青年编委,《Applied Biochemistry and Biotechnology》编委。中国微生物学会酶工程专业委员会委员,中国生物化工青年委员会委员,湖北省生物催化与酶工程技术引智示范基地负责人,湖北省微生物学会理事,湖北省合成生物学学会理事

研究方向:酶定向进化方法学的开发(计算机辅助的精准设计、机器学习的酶分子改造);含亚铁血红素Heme氧化还原酶的酶学及酶工程(P450酶及UPO酶元件创制与改造);细胞色素P450在医药、天然产物生物合成中的应用(人工生物合成途径的创建)

二、教育背景

2005–2010  华东理工大学生物反应器工程国家重点实验室,博士学位

2001–2005  河北工业大学,生物工程系本科生,学士学位

三、工作经历

2017至今     湖北大学生命科学学院,教授

2014–2017  德国马普所(煤炭化学研究所),博士后研究员

2011–2014  新加坡国立大学化学与生物分子工程系,研究员

四、科研项目

1. 科技部“合成生物学”重点研发计划课题项目,2019YFA0905002,人工途径生物酶元件的理性设计与结构改造,2020-12024-12500万元,在研,主持

2. 科技部重点研发计划子课题项目,2021YFC2102703, 多酶体系中自然和人工辅因子的再生与调控策略,2021-12024-1163万元,在研

3. 国家自然科学基金委员会,面上项目,21977026,新型P450甾体羟化酶的分子调控机制及其理性改造,2020-01 2023-1266万元,在研,主持

4. 湖北省科技厅外专处,引智基地项目,XKCX2019000002,生物催化与酶工程技术, 2020-01至今,110万元,主持,在研

5. 国家自然科学基金委员会,青年科学基金项目,21702052,基于P450酶定向羟化的去甲(伪)麻黄碱对映体新合成途径研究,2018-01 2020-1226万元,在研,主持

五、代表性论文(IF>10#共同第一作者,*通讯作者)

1. Zili Zhang, Chenghua Gao, Jing Zhao, Xiao-Gang Peng, Qian Li, Aitao Li*. A designed chemoenzymatic route for efficient synthesis of 6-dehydronandrolone acetate: a key precursor in the synthesis of C7-functionalized steroidal drugs. ACS Catalysis 2023, 13, 13111–13116.

2. Zhongwei Zhang#, Lin Fang#, Fei Wang, Yu Deng, Zhengbin Jiang, Aitao Li*. Transforming Inert Cycloalkanes into α,ω-Diamines by DesignedEnzymatic Cascade Catalysis. Angew. Chem. Int. Ed. 2023, e202215935.

3. Ruiwen Hu#, Anjie Gong#, Langxing Liao#, YanXin Zheng#, Xin Liu, Peng Wu, Fushuai Li, Huili Yu, Jing Zhao, Long-Wu Ye*, Binju Wang*, Aitao Li*. Biocatalytic aminohydroxylation of styrenes for efficient synthesis of enantiopure β-amino alcohols. Chinese Journal of Catalysis. 2023, 44, 171–178.

4. Aitao Li, Qian Wang, Xitong Song, Xiaodong Zhang, Jian-Wen Huang, Chun-Chi Chen, Rey-Ting Guo*, Binju Wang*, Manfred T. Reetz*. Engineering of a P450based Kemp eliminase with a new mechanism. Chinese Journal of Catalysis. 2023,47, 191199.

5. Xiaodong Zhang, Panpan Shen, Jing Zhao, Yueyue Chen, Xian Li, Jian-Wen Huang, Lilan Zhang, Qian Li, Chenghua Gao, Qiong Xing, Chun-Chi Chen, Rey-Ting Guo,* and Aitao Li*. Rationally Controlling Selective Steroid Hydroxylation via Scaffold Sampling of a P450 Family.. ACS Catalysis, 2023, 13 (2), 1280–1289.

6. Yaqin Peng#, Chenghua Gao#, Zili Zhang, Shijie Wu, Jing Zhao*, Aitao Li.*. A Chemoenzymatic Strategy for the Synthesis of Steroid Drugs Enabled by P450 Monooxygenase-Mediated Steroidal Core Modification. ACS Catalysis, 2022, 12, 2907-2914.

7. Chun-Chi Chen#, Meng Dai#, Lilan Zhang#, Jing Zhao, Wei Zeng, Min Shi, Jian-Wen Huang, Weidong Liu, Rey-Ting Guo*, Aitao Li.*. Molecular Basis for a Toluene Monooxygenase to Govern Substrate Selectivity. ACS Catalysis, 2022, 12, 2831-2839.

8. Fei Wang#, Jing Zhao#, Qian Li#, Jun Yang, Renjie Li, Jian Min, Xiaojuan Yu, Gao-Wei Zheng, Hui-Lei Yu, Chao Zhai, Carlos G. Acevedo-Rocha, Lixin Ma, Aitao Li*. One-pot biocatalytic route from cycloalkanes to α, ω‐dicarboxylic acids by designed Escherichia coli consortia. Nature communications, 2020, 11, 5035.

9. Zhongwei Zhang#, Qian Li#, Fei Wang#, Ren-Jie Li, Xiaojuan Yu, Lixin Kang, Jing Zhao and Aitao Li.*. One-Pot Biosynthesis of 1, 6-Hexanediol from Cyclohexane by de novo Designed Cascade Biocatalysis. Green Chemistry, 2020, 2020, 22, 7476-7483.

10. Aitao Li,*# Carlos G Acevedo-Rocha,* # Lorenzo DAmore,# Jinfeng Chen,# Yaqin Peng, Marc Garcia-Borràs, Chenghua Gao, Jinmei Zhu, Harry Rickerby, Sílvia Osuna*, Jiahai Zhou*, Manfred T Reetz*. Regioand Stereoselective Steroid Hydroxylation at the C7Position by Cytochrome P450 Monooxygenase Mutants. Angew. Chem. Int. Ed. 2020, 59, 12499–12505. (Hot paper, highlighted in Synfacts)

11. Hangyu Zhou,# Binju Wang,# Fei Wang, Xiaojuan Yu, Lixin Ma, Aitao Li*, Manfred T. Reetz*. Chemo- and Regioselective Dihydroxylation of Benzene to Hydroquinone Enabled by Engineered Cytochrome P450 Monooxygenase. Angew. Chem. Int. Ed. 2019, 58, 764–768 (Back cover).

12. Yucai He*, Yun Ding , Cuiluan Ma , Junhua Di , Chunxia Jiang and Aitao Li*. One-pot conversion of biomass-derived xylose to furfuralcohol by a chemo-enzymatic sequential acid-catalyzed dehydration and bioreduction. Green Chemistry, 2017, 19 (16), 3844-3850.

13. Ai-Tao Li#, Ge Qu#, Zhoutong Sun*, Manfred T Reetz*. Statistical analysis of the benefits of focused saturation mutagenesis in directed evolution based on reduced amino acid alphabets. ACS Catalysis, 2019, 9, 7769-7778.

14. Aitao Li,# Binju# Wang, Adriana Ilie, Kshatresh D. Dubey, Gert Bange, Ivan V. Korendovych, Sason Shaik*, Manfred T. Reetz*. A redox-mediated Kemp eliminase. Nature communications, 2017, 8, 14876.

15. Aitao Li, Adriana Ilie, Zhoutong Sun, Richard Lonsdale, Jian-He Xu, Manfred T. Reetz*. Whole-Cell-Catalyzed Multiple Regio- and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution. Angew. Chem. Int. Ed. 2016, 55, 128,12205-12208.

16. Carlos G. Acevedo-Rocha#, Aitao Li #, Lorenzo D’Amore#, Sabrina Hoebenreich, Joaquin Sanchis, Paul Lubrano, Matteo P. Ferla, Marc Garcia-Borràs, Sílvia Osuna*, Manfred T. Reetz*. Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics. Nature communications, 2021, 12, 1621.

17. Ge Qu, # Aitao Li,# Carlos G AcevedoRocha,# Zhoutong Sun*, Manfred T Reetz*. The crucial role of methodology development in directed evolution of selective enzymes. Angew. Chem. Int. Ed. 2020, 59, 1320413231.

六、专利

1. 李爱涛; 周航宇; 王婓; 余小娟; 一种P450BM3突变体及其在以苯或苯酚为底物合成对苯二酚中的应用, 2018-09-27, 中国, 201811127439.5. (专利)

2. 李爱涛; 赵晶; 王斐; 李倩; 余小娟; 彭雪盈; 陈小漫; 一种生产α,ω-二元羧酸的整细胞生物催化方法及其应用, 2020-3-3, 中国, 202010139295.6. (专利)

3. 李爱涛; 张中伟; 赵晶; 李倩; 李仁结; 王斐; 余小娟; 彭彤; α,ω-二元醇的生物催化合成方法, 2020-3-31, 中国, 202010244255.8. (专利)

4. 李爱涛,彭雅琴,高成华,赵晶,张铮斌,李纯,一种细胞色素P450BM3突变体及其在醋酸群勃龙合成中的应用,2021.08.24, 202110721653.9

5. 李爱涛,张小栋,李倩,赵晶,邓迪,一种细胞色素P450单加氧酶CYP109B2突变体及其应用,2021.05.29, 202110594533.7.

6. Aitao Li, Jing Zhao, Fei Wang, Qian Li, Xiaojuan Yu, Xueying Peng, Xiaoman Chen, Whole-cell biocatalysis method for producing α,ω-dicarboxylic acids and use thereof. 2021.01.26, US2021/0324426A1.

七、 获奖及荣誉

1. 2022,国家级青年人才

2. 2021,中国酶工程“优秀青年酶工程学家”

3. 2021,国家“十三五”科技创新成就展

4. 2021,全国商业科技进步特等奖

5. 2021,湖北大学青年科学家十大科技成果

6. 2019,湖北省杰青

7. 2018,湖北省省级人才

8. 2017,湖北省省级人才

9. 多次获优秀班主任、优秀教师奖以及连续4年获年度考核优秀

10. 导研究生获国家励志奖学金(2019

11. 研究生获得国家留学基金委(CSC)资助,格罗宁根大学攻读博士学位

12. 指导学生获全国大学生生命科学创新创业大赛奖多次(2019-2021

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