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李倩

作者:  发布时间:2022-12-18  阅读次数:

 

一、基本信息

李倩,博士,副教授,硕士研究生导师

电子邮件:qianli1988@hotmail.com

研究领域:真菌细胞色素P450的挖掘、鉴定和表征;甾体药物的生物合成;抗菌肽的生物合成

二、教育背景

2013.09-2019.02  荷兰格罗宁根大学,理学博士

2010.09-2013.06  华中师范大学,理学硕士

2006.09-2010.06黄冈师范学院,理学学士

三、工作经历

2022.03 至今    湖北大学生命科学学院,讲师,副教授

2019.05-2022.02湖北大学生命科学学院,博士后

四、科研项目

1. 国家重点研发计划子课题,2021YFC2100101, 工业酶的智能算法研究,2021.07–2024.0689万,主持

2. 湖北大学校基金,金龟子绿僵菌中新型11α-甾体羟化酶的挖掘、改造及分子调控机制研究,2021.12-2023.122万,主持

3. 湖北省科技活动项目择优资助,2019.10–2021.086万,主持

4. 脱氧可的松17α-单酯的酶法合成,浙江仙居君业药业有限公司,2021-202330万元,主持,在研

五、代表性文章

1. Qian Li#, Zhongwei Zhang#, Jing Zhao*, Aitao Li*. Recent advances in the sustainable production of α, ω-C6 bifunctional compounds enabled by chemo-/biocatalysts. Green chemistry. 2022, 24: 4270-4303.

2. Ruben Cebrian#, Qian Li#, Pablo Penalver, Efres Belmonte-Reche, Maria Andres-Bilbao, Ricardo Lucas, Maria Violante de Paz, Oscar P. Kuipers *, Juan Carlos Morales *, Chemically tuning resveratrol for the effective killing of Gram-negative pathognes. Journal of natural products, 2022, 85(6),1459-1473.

3. Qian Li#, Ruben Cebrian#, Weihui Wu, Huan Ren, Manuel Montalban-Lopez, Oscar P. Kuipers*. Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens. Communications biology2021, 4: 31.

4. Fei Wang#, Jing Zhao#, Qian Li#, Jun Yang, Renjie Li, Jian Min, Xiaojuan Yu, Gao-Wei Zheng, Hui-Lei Yu, Chao Zhai, Carlos G. Acevedo-Rocha, Lixin Ma, Aitao Li*. One-pot biocatalytic route from cycloalkanes to α, ω‐dicarboxylic acids by designed Escherichia coli consortia. Nature communications, 2020, 11:5035

5. Zhongwei Zhang#, Qian Li#, Fei Wang#, Ren-Jie Li, Xiaojuan Yu, Lixin Kang, Jing Zhao, Aitao Li.*. One-Pot Biosynthesis of 1, 6-Hexanediol from Cyclohexane by de novo Designed Cascade Biocatalysis. Green Chemistry, 2020, 22,7476

6. Xiaodong Zhang#, Yaqin Peng#, Jing Zhao#, Qian Li, Xiaojuan Yu, Carlos G. Acevedo‑Rocha, Aitao Li*. Bacterial cytochrome P450‑catalyzed regio and stereoselective steroid hydroxylation enabled by directed evolution and rational design. Bioresources and Bioprocessing. 2020, 7: 2.

7. Qian Li, Manuel Montalban-Lopez, Oscar P. Kuipers*. Feasability of introducing a thioether ring in vasopressin by nisBTC Co-expression in Lactococcus lactis. Frontiers in microbiology, 2019, 10: 1508.

8. Qian Li, Manuel Montalban-Lopez, Oscar P. Kuipers*. Increasing antimicrobial activity of nisin-based lantibiotics against Gram-negative pathogens. Applied and environmental microbiology. 2018, 84(12), e00052-18.

9. Liang Zhou, Jinfeng Shao, Qian Li, Oscar P. Kuipers*. Incorporation of tryptophan analogues into the lantibiotic nisin. Amino acids. 2016,48(5): 1309-1318.

10Wenjin Li#, Qian Li#, Deli Liu*, Mingwu Ding*. Synthesis, fungicidal activities and sterol 14α-demethylase binding interactions of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. Journal of agriculture and food chemistry. 2013, 61 (7), 1419-1426.

六、专利

1. Qian Li, Oscar P. Kuipers. Antimicrobial peptides and admixtures therefore showing antimicrobial activity against Gram-negative pathogens, PCT/NL2018/050385.

2. Aitao Li, Jing Zhao, Fei Wang, Qian Li, Xiaojuan Yu, Xueying Peng, Xiaoman Chen, Whole-cell biocatalysis method for producing α,ω-dicarboxylic acids and use thereof. 2021.01.26, US2021/0324426A1.

3. 李爱涛,赵晶,王斐,李倩,余小娟,彭雪盈,陈小漫,一种生产α,ω-二元羧酸的整细胞生物催化方法及其应用, 2020.03.03ZL202010139295.6.

4. 李爱涛,张中伟,赵晶,李倩,李仁结,王斐,余小娟,彭彤,α,ω二元醇的生物催化合成方法,2020.03.31, 202010244255.8.

5. 李爱涛,李倩,王玲,魏灵睿,一种编码禾谷镰孢菌来源的P450酶和细胞色素P450还原酶的基因序列及其重组菌株, 2022.11.16, 202211427007.2.

 

七、获奖及荣誉

1. 湖北省省级人才(2021

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