一、基本情况

郁慧丽，博士，副教授，硕士研究生导师

电子邮件：huiliyu(AT)hubu.edu.cn

研究领域：细菌次级代谢途径中P450酶的发现、挖掘，酶工程和生物催化

二、教育背景

2013.10–2018.10  德国马尔堡大学药物生物与生物技术研究所，理学博士

2010.09–2013.06  山东大学微生物技术国家重点实验室，理学硕士

2006.09–2010.06  山东大学生命科学学院，理学学士

三、工作经历

2021.10至今          湖北大学生命科学学院，副教授

2020.12–2021.09  湖北大学生命科学学院，讲师

2018.11–2019.11  德国马尔堡大学，药物生物与生物技术研究所，研究助理

四、发表论文

1. Yu H, Xie X, Li SM*. (2019) Coupling of cyclo-l-Trp-l-Trp with hypoxanthine increases the structure diversity of guanitrypmycins. Organic Letters 21, 9104–9108.

2. Yu H, Li SM*. (2019) Two cytochrome P450 enzymes from Streptomyces sp. NRRL S-1868 catalyze distinct dimerization of tryptophan-containing cyclodipeptides. Organic Letters 21, 7094–7098.

3. Yu H, Xie X, Li SM*. (2018) Coupling of guanine with cyclo-l-Trp-l-Trp mediated by a cytochrome P450 homologue from Streptomyces purpureus. Organic Letters 20, 4921–4925.

4. Liu J^#, Yu H^#, Li SM*. (2018) Expanding tryptophan-containing cyclodipeptide synthase spectrum by identification of nine members from Streptomyces strains. Applied Microbiology and Biotechnology 102, 4435–4444.

5. Yu H, Liebhold M, Xie X, Li SM*. (2015) Tyrosine O-prenyltransferases TyrPT and SirD displaying similar behavior toward unnatural alkyl or benzyl diphosphate as their natural prenyl donor dimethylallyl diphosphate. Applied Microbiology and Biotechnology 99, 7115–7124.

6. Yu H^#, Li H^#, Gao D, Gao C, Qi Q*. (2015) Secretory production of antimicrobial peptides in Escherichia coli using the catalytic domain of a cellulase as fusion partner. Journal of Biotechnology 214, 77–82.

7. Gao D, Wang S, Li H, Yu H, Qi Q*. (2015) Identification of a heterologous cellulase and its N-terminus that can guide recombinant proteins out of Escherichia Coli. Microbial Cell Factories 14, 49.

8. Wang S, Ma C, Yu H, Huang C, Qi Q*. (20) Development of a method for the efficient release of N-glycans from glycoproteins generating native deglycosylated proteins. 2012, Enzyme and Microbial Technology 51, 139–142.

9. 王圣钧, 郁慧丽, 翟琳, 王倚, 梁泉峰, 祁庆生*. 人GLP-1-IgG Fc融合蛋白在毕赤酵母中的高效表达, 2011, [J].生物技术, 21(4), 29–33.

五、获奖

1. 2013年，国家留学基金委（CSC）奖学金博士研究生项目

2. 2012年，研究生国家奖学金

3. 2009年，山东大学优秀学生二等奖学金

4. 2008年，山东大学优秀学生三等奖学金