一、基本信息

罗静雯，博士，副教授，硕士生导师

电子邮箱：jwluo0227@163.com

研究方向：靶向药物传递系统设计，缓控释给药系统研究，癌症的基因治疗和免疫治疗

招生专业：生物学、生物与医药

二、教育背景

2013.09–2019.06  四川大学华西药学院，药剂学，理学博士

2009.09–2013.06  武汉科技大学医学院，药学，理学学士

三、工作经历

2021.09至今          湖北大学生命科学学院，副教授

2019.07–2021.07  湖北大学生命科学学院，博士后，合作导师：马立新教授

四、科研项目

1. 国家自然科学基金青年基金项目，2021.01–2023.12，24万，主持

2. 中国博士后特别资助项目（站中），2020.01–2021.12，18万，主持

3. 中国博士后面上项目（一等资助），2019.10–2021.08，12万，主持

4. 湖北省科技活动项目择优资助，2019.10–2021.08，6万，主持

5. 湖北大学青年基金，2022.01–2023.12，2万，主持

6. 国家自然科学基金面上项目，2019.01–2022.12，60万，参与

7. 国家自然科学基金面上项目，2017.01–2020.12，53万，参与

五、代表性论文（#共同一作，*通讯作者）

1. Cheng Y, Wang C, Wang H, Zhang Z, Yang X, Dong Y, Ma L^*, and Luo J^*. (2022) Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy. BMC medicine 20,411.

2. Luo J ^#, Zhang Z ^#, Zeng Y, Dong Y, Ma L. (2021) Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis. Carbohydrate Polymers 263, 117964.

3. Zhang Z, Ma L^*, and Luo J^*. (2021) Chondroitin Sulfate-Modified Liposomes for Targeted Co-Delivery of Doxorubicin and Retinoic Acid to Suppress Breast Cancer Lung Metastasis. Pharmaceutics 13, 3, 406.

4. Luo J, Gong T, Ma L. (2020) Chondroitin-modified lipid nanoparticles target the Golgi to degrade extracellular matrix for liver cancer management. Carbohydrate Polymers 249, 116887.

5. Luo J, Yin P, Gong T, et al. (2019) Golgi Apparatus-Targeted Chondroitin-Modified Nanomicelles Suppress Hepatic Stellate Cell Activation for the Management of Liver Fibrosis. ACS Nano 13, 3910-3923.

6. Luo J, Zhang P, Gong T, et al. (2019) Efficient weapon for protracted warfare to malaria: a chondroitin sulfate derivates-containing injectable, ultra-long-lasting meshy-gel system. Carbohydrate Polymers 214, 131-141.

7. Luo J, Zhang Z, Gong T, Fu Y. (2016) One-step self-assembled nanomicelles for improving the oral bioavailability of nimodipine. International Journal of Nanomedicine 11, 1051-1065.

8. Luo J, Zhang T, Gong T, et al. (2016) A novel injectable phospholipid gel co-loaded with doxorubicin and bromotetrandrine for resistant breast cancer treatment by intratumoral injection. Colloids and Surfaces B: Biointerfaces 140, 538-547.

9. Zhang T ^#, Luo J ^#, Gong T, et al. (2017) Novel oral administrated paclitaxel micelles with enhanced bioavailability and antitumor efficacy for resistant breast cancer. Colloids and Surfaces B: Biointerfaces 150, 89-97.

10. Li H, Zhang P, Luo J, et al. (2019) Chondroitin Sulfate-Linked Prodrug Nanoparticles Target the Golgi Apparatus for Cancer Metastasis Treatment. ACS Nano 13, 8, 9386-9396.

11. Zhang T, Peng Q, San F, Luo J, et al. (2015) A high-efficiency, low-toxicity, phospholipids-based phase separation gel for long-term delivery of peptides. Biomaterials 45, 1-9.

12. Cao X, Luo J, et al. (2015) Coencapsulated Doxorubicin and Bromotetrandrine Lipid Nanoemulsions in Reversing Multidrug Resistance in Breast Cancer in Vitro and in Vivo. Molecular Pharmaceutics 12, 274-286.

13. Jia M, Deng C, Luo J, et al. (2018) A novel dexamethasone-loaded liposome alleviates rheumatoid arthritis in rats. International Journal of Pharmaceutics, 540 57-64.

六、专利

1. 罗静雯，马立新，董衍明，张志威。纳米药物载体、纳米药物制剂、制备方法及应用。专利号：CN112220929A

2. 龚涛，罗静雯，张培，宋旭，张志荣，孙逊。一种载药网状原位相变凝胶缓释系统及其制备方法。专利号：ZL201811171012.5

3. 龚涛，李昊欢，罗静雯，张培，宋旭，张志荣，孙逊。一种高尔基体靶向的粘多糖纳米胶束及其制备方法与应用。专利号：ZL201811521626.1