一、基本信息
李倩，博士，副教授，硕士研究生导师
电子邮件：qianli1988@hotmail.com
研究领域：真菌细胞色素P450的挖掘、鉴定和表征；甾体药物的生物合成；抗菌肽的生物合成
二、教育背景
2013.09-2019.02 荷兰格罗宁根大学，理学博士
2010.09-2013.06 华中师范大学，理学硕士
2006.09-2010.06黄冈师范学院，理学学士
三、工作经历
2022.03 至今 湖北大学生命科学学院，讲师，副教授
2019.05-2022.02湖北大学生命科学学院，博士后
四、科研项目
1. 国家重点研发计划子课题，2021YFC2100101, 工业酶的智能算法研究，2021.07–2024.06，89万，主持
2. 湖北大学校基金，金龟子绿僵菌中新型11α-甾体羟化酶的挖掘、改造及分子调控机制研究，2021.12-2023.12，2万，主持
3. 湖北省科技活动项目择优资助，2019.10–2021.08，6万，主持
4. 脱氧可的松17α-单酯的酶法合成，浙江仙居君业药业有限公司，2021-2023，30万元，主持，在研
五、代表性文章
1. Qian Li#, Zhongwei Zhang#, Jing Zhao*, Aitao Li*. Recent advances in the sustainable production of α, ω-C6 bifunctional compounds enabled by chemo-/biocatalysts. Green chemistry. 2022, 24: 4270-4303.
2. Ruben Cebrian#, Qian Li#, Pablo Penalver, Efres Belmonte-Reche, Maria Andres-Bilbao, Ricardo Lucas, Maria Violante de Paz, Oscar P. Kuipers *, Juan Carlos Morales *, Chemically tuning resveratrol for the effective killing of Gram-negative pathognes. Journal of natural products, 2022, 85(6),1459-1473.
3. Qian Li#, Ruben Cebrian#, Weihui Wu, Huan Ren, Manuel Montalban-Lopez, Oscar P. Kuipers*. Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens. Communications biology，2021, 4: 31.
4. Fei Wang#, Jing Zhao#, Qian Li#, Jun Yang, Renjie Li, Jian Min, Xiaojuan Yu, Gao-Wei Zheng, Hui-Lei Yu, Chao Zhai, Carlos G. Acevedo-Rocha, Lixin Ma, Aitao Li*. One-pot biocatalytic route from cycloalkanes to α, ω‐dicarboxylic acids by designed Escherichia coli consortia. Nature communications, 2020, 11:5035
5. Zhongwei Zhang#, Qian Li#, Fei Wang#, Ren-Jie Li, Xiaojuan Yu, Lixin Kang, Jing Zhao, Aitao Li.*. One-Pot Biosynthesis of 1, 6-Hexanediol from Cyclohexane by de novo Designed Cascade Biocatalysis. Green Chemistry, 2020, 22,7476
6. Xiaodong Zhang#, Yaqin Peng#, Jing Zhao#, Qian Li, Xiaojuan Yu, Carlos G. Acevedo‑Rocha, Aitao Li*. Bacterial cytochrome P450‑catalyzed regio and stereoselective steroid hydroxylation enabled by directed evolution and rational design. Bioresources and Bioprocessing. 2020, 7: 2.
7. Qian Li, Manuel Montalban-Lopez, Oscar P. Kuipers*. Feasability of introducing a thioether ring in vasopressin by nisBTC Co-expression in Lactococcus lactis. Frontiers in microbiology, 2019, 10: 1508.
8. Qian Li, Manuel Montalban-Lopez, Oscar P. Kuipers*. Increasing antimicrobial activity of nisin-based lantibiotics against Gram-negative pathogens. Applied and environmental microbiology. 2018, 84(12), e00052-18.
9. Liang Zhou, Jinfeng Shao, Qian Li, Oscar P. Kuipers*. Incorporation of tryptophan analogues into the lantibiotic nisin. Amino acids. 2016,48(5): 1309-1318.
10，Wenjin Li#, Qian Li#, Deli Liu*, Mingwu Ding*. Synthesis, fungicidal activities and sterol 14α-demethylase binding interactions of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum. Journal of agriculture and food chemistry. 2013, 61 (7), 1419-1426.
六、专利
1. Qian Li, Oscar P. Kuipers. Antimicrobial peptides and admixtures therefore showing antimicrobial activity against Gram-negative pathogens, PCT/NL2018/050385.
2. Aitao Li, Jing Zhao, Fei Wang, Qian Li, Xiaojuan Yu, Xueying Peng, Xiaoman Chen, Whole-cell biocatalysis method for producing α,ω-dicarboxylic acids and use thereof. 2021.01.26, US2021/0324426A1.
3. 李爱涛，赵晶，王斐，李倩，余小娟，彭雪盈，陈小漫，一种生产α,ω-二元羧酸的整细胞生物催化方法及其应用, 2020.03.03，ZL202010139295.6.
4. 李爱涛，张中伟，赵晶，李倩，李仁结，王斐，余小娟，彭彤，α,ω–二元醇的生物催化合成方法，2020.03.31, 202010244255.8.
5. 李爱涛，李倩，王玲，魏灵睿，一种编码禾谷镰孢菌来源的P450酶和细胞色素P450还原酶的基因序列及其重组菌株, 2022.11.16, 202211427007.2.
七、获奖及荣誉
1. 湖北省省级人才（2021）
