吴姗

湖北大学，生命科学学院，教授

教育经历

1.2013.9-2018.7，清华大学，生物学，理学博士

2.2009.9-2013.6，华中师范大学，化学生物学交叉培养，理学学士

科研与学术工作经历：

1.2019.1-至今，湖北大学，生命科学学院，教授

主持或参加科研项目（课题）情况

国家自然科学基金面上项目，31470722，真核核糖体组装过程的结构和功能研究，2015.1-2018.12，85万元，已结题，参与

代表性研究成果和学术奖励情况：

1.Wu Shan, Tutuncuoglu Beril, Yan Kaige, Brown Hailey, Zhang Yixiang, Tan Dan, Gamalinda Micheal, Yuan Yi, Li Zhifei, Jakovljevic Jelena, Ma Chengying, Lei Jianlin, Dong Mengqiu, Woolford JLJr, Gao Ning. (2016). Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes.Nature534, 133-137. (SCI, IF=40.137)

2.Wu Shan, Tan Dan, Woolford JLJr, Dong Mengqiu., and Gao Ning. (2017). Atomic modeling of the ITS2 ribosome assembly subcomplex from cryo-EM together with mass spectrometry-identified protein-protein crosslinks.Protein Science26, 103-112. (SCI, IF=2.523)

3.Wang Jizong^*, Wang Jia^*, Hu Meijuan^*,Wu Shan, Qi Jinfeng, Wang Guoxun, Han Zhifu, Qi yijun, Gao Ning, Wang Hongwei^#, Zhou Jianmin^#, Chai Jijie^#. (2019).Ligand-triggered allosteric ADP release primes a plant NLR complex.Science364.(SCI, IF=41.058)

4.Yuan Yi^*, DuChong^*, SunCuiji^*, Zhu Jin,Wu Shan,ZhangYinlong,Ji Tianjiao, Lei Jianlin, Yang Yinmo, Gao Ning^#, and Nie Guangjun^#. (2018). Chaperonin-groel as a smart hydrophobic drug delivery and tumor targeting molecular machine for tumor therapy.Nano Letters18(2), 921-928.(SCI, IF=12.08)

5.Ma Chengying,Wu Shan, Li Ningning, Chen Yan, Yan Kaige, Li Zhifei, Zheng Lvqin, Lei Jianlin, Woolford JLJr.^#, and Gao Ning^#. (2017). Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1.Nature Structural & Molecular Biology24, 214-220. (SCI, IF=12.595)

6.Biedka Stephanie,Wu Shan, LaPeruta Amber J., Gao Ning, and Woolford JLJr. (2017). Insights into remodeling events during eukaryotic large ribosomal subunit assembly provided by high resolution cryo-EM structures.RNABiology14, 1306-1313. (SCI, IF=3.9)

7.Tutuncuoglu Beril, Jakovljevic Jelena,Wu Shan, Gao Ning, and Woolford JLJr. (2016). The N-terminal extension of yeast ribosomal protein L8 is involved in two major remodeling events during late nuclear stages of 60S ribosomal subunit assembly.RNA22, 1386-1399. (SCI, IF=4.605)

8.Zhang Dejiu, Yan Kaige, Liu Guangqiao, Song Guangtao, Luo Jiejian,Shi,Y., Cheng Erchao,Wu Shan, Jiang Taijiao., Lou Jizhong, Gao Ning, and Qin Yan. (2016). Ef4 disengages the peptidyl-trna cca end and facilitates back-translocation on the 70s ribosome.Nature Structural & Molecular Biology,23, 125-131. (SCI, IF=12.595)

9.Zhang Yixiao, Ma Chengying, Yuan Yi, Zhu Jing, Li Ningning, Chen Chu,Wu Shan, Yu Li, Lei Jianlin, and Gao Ning. (2014). Structural basis for interaction of a cotranslational chaperone with the eukaryotic ribosome.Nature Structural & Molecular Biology,21, 1042-1046. (SCI, IF=12.595)