一、基本信息

胡玉梅，博士，讲师，硕士研究生导师

电子邮件：huyumei@hubu.edu.cn

研究方向：生物催化与酶工程、酶分子改造、酶结构及催化机制解析

二、教育经历

2017.09–2020.06  天津科技大学，博士

2010.09–2013.03  天津科技大学，硕士

2011.03–2013.03  中科院天津工业生物技术研究所，联培硕士

2006.09–2010.06  中北大学，生物工程，学士

三、工作经历

2022.06至今           湖北大学生命科学学院，讲师

2020.06–2022.05  湖北大学生命科学学院，博士后

2013.04–2017.08  中科院天津工业生物技术研究所，助理研究员

四、科研项目

1. 国家自然科学基金青年基金（31600638），19万，2017–2019，主持

2. 中国博士后基金面上项目（2020M682381），8万，2020–2022，主持

3. 湖北省博士后创新研究岗（080–090457），6万，2020–2022，主持

五、代表性论文（^#并列一作，*通讯作者）

1. Hu, Y.,^# Li, H.,^# Min, J.,^# Yu, Y., Liu, W., Huang J. W., Zhang, L., Yang, Y., Dai, L.,* Chen, C. C.,* Guo, R. T.* Crystal structure and biochemical analysis of the specialized deoxynivalenol–detoxifying glyoxalase SPG from Gossypium hirsutum. International Journal of Biological Macromolecules, 2022, 200, 388-396.（一区，TOP期刊，IF：8.025）

2. Li, H.,^# Yang, Y.,^# Hu, Y.,^# Chen, C. C., Huang J. W., Min, J., Dai, L.,* Guo, R. T.* Structural analysis and engineering of aldo-keto reductase from glyphosate-resistant Echinochloa colona. Journal of Hazardous Materials，2022. DOI:https://doi.org/10.1016/j.jhazmat.2022.129191 (一区，IF：14.224)

3. Dai, L.,^# Li, H.,^# Huang J. W., Hu, Y.,^# He, M., Yang, Y., Min, J., Guo, R. T.,* Chen, C. C.* Structure-based rational design of a short-chain dehydrogenase/reductase for improving activity toward mycotoxin patulin. International Journal of Biological Macromolecules, 2022, 222, 421-428.（一区，TOP期刊，IF：8.025）

4. Dai, L.,^# Zhang X.,^# Hu Y.,^# Shen J., Zhang Q.,Zhang L., Min J., Chen, C. C., Liu Y.,^* Huang J. W.,^* Guo, R. T.^* Structural and functional insights into a nonheme iron- and α-ketoglutarate-dependent halogenase that catalyzes chlorination of nucleotide substrates. Applied and Environmental Microbiology, 2022. (TOP期刊，封面文章，IF：5.005）

5. Dai, L.,^# Qu, Y.,^# Hu, Y.,^# Min, J., Yu, X., Chen, C., Huang, J. W.,* Guo, R. T.* Catalytically inactive lytic polysaccharide monooxygenase PcAA14A enhances the enzyme-mediated hydrolysis of polyethylene terephthalate. International Journal of Biological Macromolecules, 2021, 190, 456-462.（一区，TOP期刊，IF：8.025）

6. Hu, Y., Li H., Qu Y., Zhang, X., Zhang J., Dai, L.* Biocatalytic synthesis of a novel bioactive ginsenoside using UDP-glycosyltransferase from Bacillus Subtilis 168. Catalysts, 2020, 10：289.（IF 4.501）

7. Hu, Y.,^# Min, J.,^# Qu, Y.; Zhang, X., Zhang, J., Yu, X.,* Dai, L.* Biocatalytic synthesis of calycosin-7-O-β-D-glucoside with UDP-glucose regeneration system. Catalysts, 2020, 10：258.（IF 4.501）

8. Hu, Y.,^# Xue, J.,^# Min, J.,^# Qin, L., Zhang, J.,* Dai, L.* Biocatalytic synthesis of ginsenoside Rh2 using Arabidopsis thaliana glucosyltransferase-catalyzed coupled reactions. Journal of Biotechnology, 2020, 309：107-112.（IF：3.595）

9. Hu, Y.,^# Liu, W.,^# Malwal, S. R.,Zheng, Y., Feng, X., Ko, T. P., Chen, C. C., Xu, Z., Liu, M., Han, X., Gao, J., Oldfield, E.,* Guo, R. T.* Structures of iridoid synthase from Cantharanthus roseus with bound NAD(+), NADPH, or NAD(+) /10-oxogeranial：reaction mechanisms. Angewandte Chemie International Edition, 2015, 54, 15478-15482. (一区，IF：16.823, VIP封面文章)

10. Feng, X.,^# Hu, Y.,^# Zheng, Y.,^# Zhu, W., Li, K., Huang, C. H., Ko, T. P., Ren, F., Chan, H. C., Nega, M., Bogue, S., Lopez, D., Kolter, R., Gotz, F., Guo, R. T.,* Oldfield, E.* Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production. Cell Chemical Biology, 2014, 21, 1557-1563.（一区，IF：9.039）

11. Chan, H. C.,^# Feng, X.,^# Ko, T. P.^#, Huang, C. H., Hu, Y., Zheng, Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D. C., Liang, P. H., Wang, A. H. J., Oldfield, E.,* Guo, R. T.* Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. Journal of the American Chemical Society, 2014, 136, 2892-2896. （一区，IF：16.383）

12. Hu, Y., Jia, S., Ren, F., Huang, C. H., Ko, T. P., Mitchell, D. A., Guo, R. T., Zheng, Y. * Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 2013, 69, 77-79.（IF：1.072）

13. Ren, F.,^# Feng, X.,^# Ko, T. P.,^# Huang, C. H., Hu, Y., Chan, H. C., Liu, Y. L., Wang, K., Chen, C. C., Pang, X., He, M., Li, Y., Oldfield, E.,* Guo, R. T.* Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus. ChemBioChem : a European Journal of Chemical Biology, 2013, 14, 195-199. (IF：3.461，封面文章)

14. Ren, F.,^# Ko, T. P.,^# Feng, X., Huang, C. H., Chan, H. C., Hu, Y., Wang, K., Ma, Y., Liang, P. H., Wang, A. H. J., Oldfield, E.,* Guo, R. T.* Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes. Angewandte Chemie International Edition, 2012, 51, 4157-4160. (一区，IF：16.823，封面文章)

15. Chan, H. C.,^# Zhu, Y.,^# Hu, Y., Ko, T. P., Huang, C. H., Ren, F., Chen, C. C., Ma, Y., Guo, R. T.,* Sun, Y.* Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars. Protein & Cell, 2012, 3, 123-131. (一区，IF：15.328，封面文章)

六、申请与授权专利

1. 陈纯琪，屈莹莹，戴隆海，黃建文，刘珂，张丽兰，杨云云，胡玉梅，詹志春，郭瑞庭，具纤维素结合域的PET水解酶，202010986920.0

七、获奖与荣誉称号

1. 2020年，天津市自然科学二等奖