一、基本信息

闵鉴，博士，副教授，硕士生导师

电子邮件：jianmin(at)hubu.edu.cn

通讯地址：湖北省武汉市武昌区友谊大道368号湖北大学生命科学学院B106

学术兼职：《Acta Materia Medica》青年编委

研究方向：基于靶点及结构生物学的新药设计与开发

二、教育背景

2008.09–2013.12  武汉大学，药学院，理学博士，导师：周海兵 教授

2004.09–2008.07  武汉大学，药学院，理学学士

三、工作经历

2018.09至今         湖北大学生命科学学院，讲师、副教授

2014.11–2018.08  美国伊利诺伊大学香槟分校（UIUC），化学系博士后研究员，导师：John Katzenellenbogen 教授 （美国艺术与科学学院院士、入选美国化学会药物化学名人堂）

2012.02–2013.02  美国伊利诺伊大学香槟分校（UIUC），访问学者

四、承担科研项目

1. 国家重点研发计划“绿色生物制造”重点专项，2021.07–2024.06，48.9万，在研，主持

2. 国家自然科学基金青年项目，2022.01-2024.12，24万，在研，主持

3. 中国博士后基金，2020.07-2021.12，8万，在研，主持

4. 湖北省自然科学基金青年基金，2019.09-2021.09，3万，结题，主持

5. Chemical, structural and molecular rules for fully antagonizing the estrogen receptor，R01-CA220284，$420,820/年，美国国家卫生研究所(NIH, USA)，2018年-2023年，主要技术骨干

6. Antiestrogens for Metastatic Breast Cancers Driven by Estrogen Receptors with Activating Mutations，BCRF 17-083，$100,000/年，美国乳腺癌研究基金会 (Breast Cancer Research Foundation)，2016年-2019年，主要技术骨干

五、代表性论文和专利

1. Zeng, W.; ^# Li, X.; ^# Yang, Y.; Min, J.; ^# Huang, J. W.; Liu, W.; Niu, D.; Yang, X.; Han, X.; Zhang, L.; Dai, L.; Chen, C. C.; * Guo, R. T.* Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy. ACS. Catalysis, 2022, 12, 5, 3033-3040. (共同第一作者)

2. Hu, Y.; Li, H.; Min, J.; Yu, Y.; Liu, W.; Huang, J. W.; Zhang, L.; Dai, L.; * Chen, C. C.; * Guo, R. T.* Crystal structure and biochemical analysis of the specialized deoxynivalenol–detoxifying glyoxalase SPG from Gossypium hirsutum, International Journal of Biological Macromolecules, 2022, 200, 388-396. (共同第一作者)

3. Min, J.; ^# Nwachukwu, J. C.; ^# Srinivasan, S.; Rangarajan, E.S.; Nettles, C.C.; Guillen, V. S.; Ziegler, Y.; Yan, S.; Carlson, K. E.; Hou, Y.; Kim, S. H.; Novick, S.; Pasal, B.D.; Houtman, R.; Griffin P.R.; Izard, T.; Katzenellenbogen, B. S.; Katzenellenbogen, J. A.; * Nettles, K. W. * Dual-Mechanism Estrogen Receptor Inhibitors Reveal an Ensemble of Binding Modes for Robust Breast Cancer Antagonism, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (35), e2101657118 (Highlighted by科学网、科技日报)

4. Chen, C. C.; ^# Min, J.; ^# Zhang, L.; ^# Yang, Y.; Yu, X.; * Guo, R. T.* Advanced Understanding of the Electron Transfer Pathway of Cytochrome P450s. ChemBioChem, 2021, 22, 1317-1328 (共同第一作者，封面文章)

5. Hu, Y.; ^# Xue, J.; ^# Min, J.; ^# Qin, L.; Zhang, J.; * Dai, L. * Biocatalytic synthesis of ginsenoside Rh2 using Arabidopsis thaliana glucosyltransferase-catalyzed coupled reactions. Journal of Biotechnology, 2020, 309, 107-112. (共同第一作者)

6. Hu, Y.; ^# Min, J.; ^# Qu, Y.; Zhang, X.; Zhang, J.; * Dai, L. * Biocatalytic synthesis of calycosin-7-O-β-D-glucoside with UDP-glucose regeneration system. Catalysts, 2020, 10: 258. (共同第一作者)

7. Min, J.; ^# Guillen, V. S.; Sharma, A.; Zhao, Y.; Ziegler, Y.; Gong, P.; Mayne, C. G.; Srinivasan, S.; Kim, S. H.; Carlson, K. E.; Nettles, K. W.; Katzenellenbogen, B. S.; Katzenellenbogen, J. A.* Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells. Journal of Medicinal Chemistry, 2017, 60 (14), 6321-6336.

8. Min, J.; ^# Wang, P.; Srinivasan, S.; Nwachukwu, J. C.; Guo, P.; Huang, M.; Carlson, K. E.; Katzenellenbogen, J. A.; * Nettles, K. W.; Zhou, H.-B., * Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity. Journal of Medicinal Chemistry, 2013, 56 (8), 3346-3366. (第一作者，药物化学一区)

9. Chen, C. C.; ^# Han, X.; ^# Li, X.; ^# Jiang, P.; Niu, D.; Ma, L.; Liu, W.; Li, S.; Qu, Y.; Hu, H.; Min, J.; Yang, Y.; Zhang, L.; Zeng, W.; Huang, J. W.;* Dai, L.;* Guo, R. T.* General features to enhance enzymatic activity of poly (ethylene terephthalate) hydrolysis, Nature Catalysis, 2021, 4, 425-430 (Highlighted by ChemistryViews, 科技日报, 中国科学报, MIT科技评论)

10. Chen, C. C.;^# Yu, X.; ^# Kuo, C.J.; Min, J.; Chen, S.; Ma, L.;* Liu, K.;* Guo, R. T.* Overview of antiviral drug candidates targeting coronaviral 3C-like main proteases. FEBS Journal, 2021, 288, 5089-5121.

11. Wang, F.; ^#Zhao, J.; ^# Li, Q.; ^# Yang, J.; Li, R.; Min, J.; Yu, X.; Zheng, G.W.; Yu, H.L.; Zhai, C.; Acevedo-Rocha, C.G.; Ma, L.; Li, A* One-pot biocatalytic route from cycloalkanes to α, ω‐dicarboxylic acids by designed Escherichia coli consortia. Nature Communications, 2020, 11, 5035.

12. Sharma, A.; Toy, W.; Guillen; V. S., Sharma, N.; Min, J.; Carlson, K. E.; Mayne, C. G.; Lin, S.; Sabio, M.; Greene, G., Katzenellenbogen, B. S., Chandarlapaty, S., Katzenellenbogen, J. A., * Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain. ACS Chemical Biology, 2018, 13 (12), 3374-3384.

13. Wang, L.; Guillen, V. S.; Sharma, N.; Flessa, K.; Min, J.; Carlson, K. E.; Toy, W.; Braqi, S.; Katzenellenbogen, B. S.; Katzenellenbogen, J. A.; Chandarlapaty, S.; Sharma, A., * New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons. ACS Medicinal Chemistry Letters, 2018, 9 (8), 803-808.

14. Zhao, Y.; Laws, M. J.; Guillen, V. S.; Ziegler, Y.; Min, J.; Sharma, A.; Kim, S. H.; Chu, D.; Park, B. H.; Oesterreich, S.; Mao, C.; Shapiro, D. J.; Nettles, K. W.; Katzenellenbogen, J. A.; Katzenellenbogen, B. S., * Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors. Cancer Research, 2017, 77 (20), 5602-5613.

15. Srinivasan, S.; Nwachukwu, J. C.; Bruno, N. E.; Dharmarajan, V.; Goswami, D.; Kastrati, I.; Novick, S.; Nowak, J.; Cavett, V.; Zhou, H. B.; Boonmuen, N.; Zhao, Y.; Min, J.; Frasor, J.; Katzenellenbogen, B. S.; Griffin, P. R.; Katzenellenbogen, J. A.; Nettles, K. W., * Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nature Chemical Biology, 2017, 13 (1), 111-118. （入选2017年Faculty of 1000文章）

16. Nwachukwu, J. C.; Srinivasan, S.; Zheng, Y.; Wang, S.; Min, J.; Dong, C.; Liao, Z.; Nowak, J.; Wright, N. J.; Houtman, R.; Carlson, K. E.; Josan, J. S.; Elemento, O.; Katzenellenbogen, J. A.; * Zhou, H. B.; * Nettles, K. W., * Predictive features of ligand-specific signaling through the estrogen receptor. Molecular System Biology, 2016, 12 (4), 864.

17. Katzenellenbogen, J. A.*; Katzenellenbogen, B. S.; Min, J.; Kim, S. H.;  Antiestrogens for Cancer Therapy, PCT/US18/24144.

六、国际国内学术会议及报告

1. 闵鉴, 双机制雌激素受体抑制剂的设计、合成及作用机制研究，2021国际药学前沿科学研讨会，2021-11-6至2021-11-7，武汉，会议报告。

2. J. Min, J. C. Nwachukwu, S. Srinivasan, C. C. Nettles, V. S. Guillen, Y. Ziegler, K. E. Carlson, Y. Hou, S. H. Kim, P. R. Griffin, T. Izard, B. S. Katzenellenbogen, J. A. Katzenellenbogen, K. W. Nettles, Dual mechanism estrogen receptor inhibitors, 2021年中国药物化学学术会议暨中欧药物化学研讨会, 2021年9月27-30, 沈阳.

3. J. Min, S. Srinivasan, E. S. Rangarajan, V. Sanabria Guillen, Y. Ziegler, K. E. Carlson, J. C. Nwachukwu, Y. Hou, Sung Hoon Kim, T. Izard, R. Houtman, K. W. Nettles, B. S. Katzenellenbogen, and J. A.Katzenellenbogen. Combining Direct and Indirect Modes of Antiestrogen Ligand Antagonism of Estrogen Receptor Activity in Breast Cancer. San Antonio Breast Cancer Symposium, San Antonio, December 10-14, 2019.

4. J. Min, S. Srinivasan, E. S. Rangarajan, V. Sanabria Guillen, Y. Ziegler, K. E. Carlson, J. C. Nwachukwu, Y. Hou, Sung Hoon Kim, T. Izard, R. Houtman, K. W. Nettles, B. S. Katzenellenbogen, and J. A.Katzenellenbogen. Dual Mechanism Estrogen Receptor Inhibitors Produce Robust Breast Cancer Antagonism. Nuclear Receptors Conference, Nassau, February 24-27, 2020.

5. J. C. Nwachukwu, J. Min, S. Srinivasan, E. S. Rangarajan, V. Sanabria Guillen, Y. Ziegler, K. E. Carlson, Y. Hou, Sung Hoon Kim, Y. Hou, T. Izard, R. Houtman, K. W. Nettles, B. S. Katzenellenbogen, and J. A. Katzenellenbogen. Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many LigandInduced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain. Endocrine Society Conference ENDO2020, San Francisco, March 28-31, 2020.

七、荣誉及奖励

1. 湖北省省级人才（2021）

2. 湖北大学第七届青年教师教学竞赛二等奖（2019）

3. 湖北大学生科院第三届青年教师教学竞赛一等奖（2019）