2025

1. Xiayu Li, Yanping Zhang, Xiaotong Chen, Yuxin Zhang, Owais Khan, Letian Xu. (2025) Gut microbiota variation drives differential performance in leaf beetles across host plants. Microbiome. https://doi.org/10.1186/s40168-025-02278-5

2. Anxiang Wang, Tian Meng, Ju Wang, Xiaomei Xu, Dan Li, Zhanqing Lv, Aiqi Yan, Mian Zhou, Bo Ding, Qiu Yang. (2025) Stabilisation of Tomato Yellow Leaf Curl China Virus Infectious Clones Through Micro-Homology Mediated End Joining. Plant Biotechnology Journal. https://doi.org/10.1111/pbi.70455

3. Ce Shi, Zifu Zhao, Yicheng Zhong, Xingchun Tang, Pan Luo, Meng-Xiang Sun. (2025) Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid induction. Cell. https://doi.org/ 10.1016/j.cell.2025.08.014

4. Li Chen, Yunrong Li, Xuanxuan Zhang, Lixin Ma, Cheng Zhang, Huanhuan Chen. (2025) A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers. Materials Today Bio. https://doi.org/10.1016/j.mtbio.2025.101548

5. Ling Wang, Ying Wang, Xiaogang Peng, Chenghua Gao, Xinfang Wei, Peng Chen, Pan Xiao, Qian Li, Aitao Li. (2025) Divergent evolution of fungal P450 monooxygenase unlocks simultaneous access to C12β and C15α oxy functionalization of steroids. Nature Communications. https://doi.org/10.1038/s41467-025-65736-6

6. Zhang, Q., He, S., Zhu, Z., Cheng, F., **, Y., Zhu, W., & Chen, S. (2025). Unraveling the chrono-regulatory function of PhoP in nitrogen metabolism: A multi-scale engineering framework aimed at optimizing the synthesis of poly-γ-glutamic acid in Bacillus licheniformis. Chemical Engineering Journal. https://doi.org/10.1016/j.cej.2025.165782

7. Fei Wang, Huiqi Sun, Di Deng, Yuanqing Wu, Jing Zhao, Qian Li, Aitao Li. (2025) Multidimensional engineering of Escherichia coli for efficient adipic acid synthesis from cyclohexane. Advanced Science 17:e2411938

8. Xu Y, Qi S, Zhang G, Liu D, Xu D, Qin T, Cheng Q, Kang H, Hu B, Huang Z. (2025) One-pot ligation of multiple mRNA fragments on dsDNA splint advancing regional modification and translation. Nucleic Acids Res. https://doi 10.1093/nar/gkae1280.

9. Zhu-Long Hu, Zi-Qian Li, Yu Wang, Yi-Ling Luo, Wan-Ping Guo, Ning Meng, Guo-Long Bu, Le-Le Zhang, Shu-Xin Li, Xiang-Wei Kong, Xin-Yan Fang, Qiao-Li Wang, Run-Kun Han, Zheng Zhao, Ge-Xin Zhao, Zi-Ying Jiang, Run-Xian Jin, Mu-Sheng Zeng, Qian Zhong. (2025) Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promote anti-viral innate immune evasion. Nature Communications. https://doi.org/10.1038/s41467-025-64037-2

10. Wu H, Lu Z, Yang Y, Pan R, Zhang Z, Yao X, Zhai Z, Li X, Wu G, Zhai C, Gao H. (2025) dPAFS: A nuclease-dead PfAgo-mediated fluorescence sensing platform for genotyping genome-edited rice. Biosens Bioelectron. 10.1016/j.bios.2025.117364

11. Guobao Li, Tianjiao Du, Jiening Wang, Kaiyue Jie, Zhuolu Ren, Xiaokang Zhang, Long Zhang, Shan Wu, Heng Ru. (2025) Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola viruses. Nature Communications. https://doi.org/10.1038/s41467-025-58308-1

12. Yunfan Xu, Shuopeng Qi, Gongrui Zhang, Dan Liu, Dejin Xu, Tong Qin, Qin Cheng,Han Kang, Bei Hu, Zhen Huang. (2025) One-pot ligation of multiple mRNA fragments on dsDNA splint advancing regional modification and translation. Nucleic Acids Research. https://doi.org/10.1093/nar/gkae1280.

13. Wang S, Zhu J, Zhao Y, Mao S, He Y, Wang F, Jia T, Cai D, Chen J, Wang D, Chen S. Developing a Bacillus licheniformis platform for de novo production of γ-aminobutyric acid and other glutamate-derived chemicals. Metab Eng. https://doi.org/10.1016/j.ymben.2024.12.010

14. FangSheng Fu, HuanHuan Chen, Yu Chen, Ying Yuan, Yong Zhao, Aixi Yu, XianZheng Zhang. (2025) Engineered bacillus subtilis enhances bone regeneration via immunoregulation and anti-infection. Bioactive Materials. DOI: 10.1016/j.bioactmat.2025.01.003

15. Muhammad Azhar Hussain, Yong Huang, Dan Luo, Sundas Saher Mehmood, Ali Raza, Liu Duan, Xuekun Zhang, Yong Cheng, Hongtao Cheng, Xiling Zou, Xiaoyu Ding, Liu Zeng, Bian Wu, Keming Hu, Yan Lv. (2025) Integrative analyses reveal Bna-miR397a-BnaLAC2 as a potential modulator of low-temperature adaptability in Brassica napus L. Plant biotechnology journal. https://doi.org/10.1111/pbi.70017

16. Juanjuan Feng, Xuanzheng Xiao, Xinting Xia, Jian Min, Weiying Tang, Xinyi Shi, Ke Xu, Guizhen Zhou, Kangkang Li, Panpan Shen, Rujuan Bao, Shuyao Wu, Mengjia Lin, Kun Yuan, Zhengke Lian, Xiaotong Zhai, Jun Wu, Chunyong Ding, Huixin Zhao, Xinqi Gong, Sulin Zhang, Jianping Jin, Dali Li, Mingyao Liu, Youqiong Ye, Buyong Ma, Rey-Ting Guo, Ao Zhang, Xiufeng Pang  (2025) A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers, Cancer Cell. DOI: 10.1016/j.ccell.2025.07.006 

17. Yitong Li, Yunyun Yang, Mengting Zhang, Xiaoping Yue, Rey-Ting Guo, Zedu Huang, Fener Chen. (2025) Mutagenesis of a Single Site Inverts the Stereopreference of Imine Reductase. ACS Catalysis 15, 2192-2199. DOI: https://doi.org/10.1021/acscatal.5c00046

18. Chun-Chi Chen, Zhi-Pu Yu, Ziwei Liu, Yongpeng Yao, Peter-Leon Hagedoorn, Rob Alexander Schmitz, Lujia Yang, Lu Yu, Aokun Liu, Xiang Sheng, Hao Su, Yaqing Ma, Te Wang, Jian-Wen Huang, Lilan Zhang, Juzhang Yan, Jinping Bao, Chengsen Cui, Xian Li, Panpan Shen, Wuyuan Zhang, Jian Min, Chang-Yun Wang, Rey-Ting Guo, Shu-Shan Gao. (2025) Chanoclavine synthase operates by an NADPH-independent superoxide mechanism. Nature. https://doi.org/10.1038/s41586-025-08670-3

19. Jie Qiao, Junqi Zhang, Qingyuan Jiang, Shuqi Jin, Ruyi He, Bin Qiao, Yi Liu. (2025) Boosting CRISPR/Cas12a intrinsic RNA detection capability through pseudo hybrid DNA–RNA substrate design, Nucleic Acids Research. https://doi.org/10.1093/nar/gkaf510

20. Panpan Shen, Xinyu Lu, Caihong Wang, Jian Min, Jian-Wen Huang, Junjie Luo, Yushun Sun, Chun-Chi Chen, Rey-Ting Guo. (2025) Structural and Mechanistic Investigations of a High-Fidelity Cas9 from Parasutterella secunda. ACS Catalysis. https://doi.org/10.1021/acscatal.5c02993

21. Zhenzhen Xie, Lilan Zhang, Qiru Li, Jian-Wen Huang, Yanting He, Hualin Zhang, Xinyue Wang, Jian Min, Chun-Chi Chen, Rey-Ting Guo. (2025) Apramycin Biosynthesis: Structure and Mechanism of Action of a New-Type Transaldolase AprG from Streptoalloteichus tenebrarius. ACS Catalysis. https://doi.org/10.1021/acscatal.5c02753

22. Rao, Y., Wang, J., Zhao, R., Zhan, Y., Ma, X., He, P., & Chen, S. (2025). Efficient sustainable production of protocatechuic acid from glucose by engineered Bacillus licheniformis. Chemical Engineering Journal. https://doi.org/10.1016/j.cej.2025.159320

23. Li Chen, Mengyi Zhan, Li Zhang, Zhuohang Xiong, Chi Zhang, Xuanxuan Zhang, Zhengyang Yang, Lixin Ma, Yibin Cheng, Huanhuan Chen. (2025) Dual-layer microneedles for immunomodulation and infection-responsive therapy in diabetic foot ulcers. Materials Today Bio. https://doi.org/10.1016/j.mtbio.2025.102490

24. Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, and Shanshan Li. (2025) Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6. Advanced Science. doi: 10.1002/advs.202508525.

25. Suqin Zhang, Meng Li, Jingyi Zeng, Songli Zhou, Feifan Yue, Zhaoyi Chen, Lixin Ma, Yang Wang, Fei Wang, Jingwen Luo. (2025) Somatostatin receptor-targeted polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic hepatocellular carcinoma therapy. Journal of Nanobiotechnology. doi: 10.1186/s12951-025-03214-3

26. Zhongwei Zhang, Julin Chen, Ying Wang, Aitao Li. (2025) Biocatalytic Conversion of Caprolactam to 1, 6-Hexanediamine: A Novel Route for Nylon Monomer Production. ACS Catalysis. https://doi.org/10.1021/acscatal.5c05397

27. Chenghu Liu, Yipeng Liu, Yixuan Li, Mei Liu, Hengyi Lu, Xiaolong Liu, Min Lu. (2025) Host-dominated oxidative cascades and transgenerational Cu transfer drive population collapse in Spodoptera frugiperda under chronic CuO nanoparticle exposure: Implications for nano-pesticide environmental risk assessment. Environment International. https://doi.org/10.1016/j.envint.2025.109874

28. Huili Yu, Lei Hu, Xin Ruan, Xiaogang Peng, Pan Xiao, Ningjia Ao, Peng Chen, Chao Yang, Shu-Ming Li, Zhiyong Guo, Aitao Li. (2025) Rational Mining and Engineering of Unique P450 Enzymes Enable Production of Diverse Dimeric Tryptophan-Containing Diketopiperazine Alkaloids. ACS Catalysis. https://doi.org/10.1021/acscatal.5c06701

29. Qingyuan Jiang, Shuqi Jin, Zhichao Qin2, Junqi Zhang, Ruyi He, Zhuo Chen, Bin Qiao, Jie Qiao, Yi Liu. (2025) CRISPR/Cas12a DTR system: a topology-guided Cas12a assay for specific dual detection of RNA and DNA targets. Nucleic Acids Research. 53, gkaf893

30. Junqi Zhang, Mengjia Zhua, Hongbin Yan, Jie Qiao, Yi Liu. (2025) Split CRISPR/Cas Systems: Pioneering Solutions for Molecular Diagnostics Challenges. Biosensors & Bioelectronics. https://doi.org/10.1016/j.bios.2025.118177

31. Guangbo Yan, Xia Li, Longyu Wang, Fei Wang, Siyuan Lv, Xiaolan Yu, Zhongchen Li, Jiakai Cui, Baotong Sun, Jia Hou, Wenqiang Li, Xiaochen Xie, Shuai Zhao, Zhiwei Zhang, Wanping Chen, Yanhong Peng, Yang Liu, Lixin Ma. (2025) In vitro programmable DNA cleavage by a eukaryotic Argonaute. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaf561

32. Meng Li, Songli Zhou, Suqin Zhang, Xingyu Xie, Junqi Nie, Qi Wang, Lixin Ma, Yibin Cheng, Jingwen Luo. (2025) Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels. Journal of Nanobiotechnology. 23:441

33. Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang. (2025) A Human Engineered Heart Tissue-Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin. Advanced Science. 28:e03173

34. Longyu Wang, Xiaochen Xie, Fuyong Huang, Qiang Wei, Tianxin Cai, Na Yu, Shi Chen, Fei Wang, Wanping Chen, Chin-Yu Chen, Chunhua Li, Lixin Ma. (2025) An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum. Advanced Science. 14: e2416631

35. Wenjing Dai, Qi Yu, Rui Ma, Zhu Zheng, Lingling Hong, Yuqing Qi, Fei He, Min Wang, Feng Ge, Xilan Yu, Shanshan Li. (2025) PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1. Nature Communications. 16: 4030

36. Yan Li, Xuelian Guo, Jiayi Song, Kun Xu, Tian Qin, Xianhua Zhang, Zhaojian Song , Yuchi He, Biaoming Zhang, Haitao Zhang, Haitao Li, Wenya Yuan. (2025) OsSPL14 and OsNF-YB9/YC8-12 subunits cooperate to enhance grain appearance quality through promotingWaxyandPDIL1-1expression in rice. Plant Communications. 2:101348

37. Suqin Zhang, Meng Li, Jingyi Zeng, Songli Zhou, Feifan Yue, Zhaoyi Chen, Lixin Ma, Yang Wang, Fei Wang, Jingwen Luo. (2025) Somatostatin receptor-targeted polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic hepatocellular carcinoma therapy. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-025-03214-3

38. Wenxue Jiang, Miao Wu, Zhou Gong, Linhua Han, Xiaoqi Cheng, Xiaoqin Tang, Xiaolong Yu, Xu Dong, Yibin Cheng, Lixin Ma, Qiong Xing. (2025) Structure-guided engineering of a Rieske-type aromatic dioxygenase for enhanced consumption of 3-phenylpropionic acid in Escherichia coli. Journal of Hazardous Materials. 491, 137954

39. Xu Dong, Manli Xu, Miao Wu, Ying Wang, Xiaoqi Cheng, Wenxue Jiang, Dule Zheng, Ahmed Habiba Omar, Yibin Cheng , Aitao Li , Lixin Ma , Qiong Xing. (2025) Structural and catalytic insights into MhpB: A dioxygenase enzyme for degrading catecholic pollutants. Journal of Hazardous Materials. 488, 137431

40. Xiaolong Zhang, Bin Feng, Yu Wang, Tingting Mu, Ming Zheng, Changbin Gao, Biaoming Zhang, Yan Li, Haitao Zhang, Wenya Yuan, Wei Hua, Haitao Li. (2025) Targeted disruption of five Bna.BRC1 homologs in rapeseed generates a highly branched germplasm for its multifunctional utilization. Plant Communications. 20:101319

41. Feng Wang, Haijiang Xu, Chendi Zhang, Jialin Xue, Zhuang Li. (2025) Target DNA-induced filament formation and nuclease activation of SPARDA complex. Cell Research. https://doi.org/10.1038/s41422-025-01100-z

42. Huanhuan Qi, Jing Wang Xin Wang, Kun Liang, Meicheng Ke, Xueqing Zheng, Wenbin Tang, Ziyun Chen, Yinggen Ke, Pingfang Yang, Fazhan Qiu, Feng Yu. (2025) ZmEREB180 modulates waterlogging tolerance in maize by regulating root development and antioxidant gene expression. Plant Biotechnology Journal. https://doi: 10.1111/pbi.70030

43. Linliang Zhang, Yali Qin, Mingzhou Chen. (2025) Flavivirus NS₂A orchestrates reticulophagy to enhance viral pathogenicity. Autophagy 7, 1–2

44. Lixin Kang, Haoran Li, Kexin Lin, Shen Hu, Song Liu, Yuben Qiao, Ying Wang, Aitao Li. (2025) Regioselectivity Switching in CYP107Pdh-Catalyzed VD3 Hydroxylation: A Structure-Guided Approach To Improve Calcidiol Production. ACS Catalysis 0, 15. DOI: 10.1021/acscatal.5c00444

45. Affiliations expandDi Deng, Zhihui Jiang, Lixin Kang, Langxing Liao, Xiaodong Zhang, Yuben Qiao, Yang Zhou, Liulin Yang, Binju Wang, Aitao Li. (2025) An efficient catalytic route in haem peroxygenases mediated by O₂/small-molecule reductant pairs for sustainable applications. Nature Catalysis 8, 20–32

46. Yunyun Yang, Yanling Li, Licheng Yao, Kexiang Dai, Xiaolong Fu, Aoyue Ge, Jian-Wen Huang, Rey-Ting Guo, Chun-Chi Chen. (2025) Structural Insights into the N–N Bond-Formation Mechanism of the Heme-Dependent Piperazate Synthase KtzT. ACS Catalysis 15, 1265–1273

47. Siyu Li, Jian-Wen Huang, Jian Min, Hao Li, Meidan Ning, Shuyu Zhou, Yu Yang, Chun-Chi Chen & Rey-Ting Guo. (2025) Molecular insights into a distinct class of terpenoid cyclases. Nature Communications 16, 207

48. Hongxun Gao, Yakun Fan, Xuwei He, Xiaogang Peng, Zhen Li, Yanxin Zheng, Shengbiao Ji, Longwu Ye, Aitao Li, Binju Wang, Jing Zhao. (2025) Mechanistic Insights into the Selective C–S Bond Formation by P450 TleB. ACS Catalysis 14, 10658–10669

49. Shipeng Li, Xuanhao Zhang, Haodong Huang, Mou Yin, Matthew A. Jenks, Dylan K. Kosma, Pingfang Yang, Xianpeng Yang, Huayan Zhao, Shiyou Lü. (2025) Deciphering the core shunt mechanism in Arabidopsis cuticular wax biosynthesis and its role in plant environmental adaptation. Nature Plants 11, 165–175

50. Yuxin Zhang, Chengjie Tu, Jianyang Bai, Xiayu Li, Ziyue Sun, Letian Xu. (2025) Metabolic enhancement contributed by horizontal gene transfer is essential for dietary specialization in leaf beetles. Proceedings of the National Academy of Sciences of the United States of America 122, e2415717122