一、基本信息

陈明周，博士，二级教授，博士生导师

电子邮件：chenmz(at)hubu.edu.cn

研究领域：医学病毒学、分子病毒学、新型疫苗及抗病毒药物

研究方向：

团队长期的研究方向是解析病毒感染和致病的分子机制，主要针对重要的人类和动物病毒（寨卡病毒、人副流感病毒、呼吸道合胞病毒、肠道病毒71、新冠病毒、乙肝病毒、埃博拉病毒和尼帕病毒等）的感染、复制与致病机制研究；解析病毒的感染过程及在宿主细胞内的复制、组装、释放及病毒与宿主细胞的相互机制；探究病毒调控机体脂类代谢的分子机制；发现、鉴定关键的抗病毒靶点及抗病毒小分子药物筛选；基于纳米颗粒平台的新型病毒疫苗研发。

二、教育背景

1996.09-2002.07 华中农业大学，微生物学，博士学位

1992.09-1996.06 华中农业大学，本科，学士学位

三、工作经历

2023.8至今湖北大学生命科学学院，教授，博士生导师

2019-2023 武汉大学生命科学学院，副院长

2018-2019 武汉大学生命科学学院，院长助理

2017-2023 武汉大学病毒学国家重点实验室，副主任

2009-2023 武汉大学生命科学学院/病毒学国家重点实验室，教授

2005-2009 美国克利夫兰临床医院，分子遗传学系，博士后

2002-2005 法国里昂第一大学感染与免疫学系，博士后

四、科研项目

1.国家自然科学基金重点项目“人副流感病毒3型复制细胞器生物合成及功能发挥的分子机制”（82130064），2022.01-2026.12，290万，主持

2.国家重点研发计划“病原学与防疫技术体系研究”专项“病毒复制与宿主相互作用研究及药物靶点发现”（2021YFC2300702），2021.12-2024.11，687万，主持

3.国家杰出青年科学基金项目“RNA病毒感染和致病的分子机制”（81825015），2019.01-2023.12，400万，主持

4.国家自然科学基金重点项目“人副流感病毒诱导的线粒体自噬及其调控先天免疫和病毒复制的机制”（31630086）2017.01-2021.12，287万，主持

5.湖北省重点研发计划“靶向宿主囊泡运输途径关键调节因子RAB11的广谱型抗呼吸道病毒多肽研发”（2023BCB087），2023.01-2025.12，100万，主持

6.国家自然科学基金面上项目“人副流感病毒3型核衣壳蛋白的功能研究”（81471939）2015.01-2018.12，100万，主持

7.国家自然科学基金面上项目“水泡性口炎病毒磷酸蛋白氨基端磷酸化的功能研究”（81271816），2013-2016，70万，主持

8.国家重点研发计划重点专项（2017YFA0505800）2017-2022，130万，参与

9.国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”（2018ZX10101004）2018-2020，114万，参与

10.教育部新世纪优秀人才支持计划2014-2016，50万，主持

11.湖北省自然科学基金创新群体（2017CFA022）2017-2019，50万，主持

12.湖北省杰出青年基金2014-2016，10万，主持

五、代表性成果（*通讯作者）

1.Liu P, Zhang S, Ma J, Jin D, Qin Y*,Chen M*. Vimentin inhibits α-tubulin acetylation via enhancing α-TAT1 degradation to suppress the replication of human parainfluenza virus type 3.PLoS Pathog. 2022. 18(9): e1010856. https://doi.org/ 10.1371/journal.ppat.1010856

2.Guo D, Yu X, Wang D, Li Z, Zhou Y, Xu G, Yuan B, Qin Y*,Chen M*. SLC35B2 acts as a dual role in the host sulfation required for EV71 infection.Journal of Virology. 2022 May 11;96(9): e0204221.doi: 10.1128/jvi.02042-21.

3.Fan S, Xu Z, Liu P, Qin Y*,Chen M*. Enterovirus 71 2A protease inhibits P-Body formation to promote viral RNA synthesisJ Virol. 2021 Sep 9; 95(19): e0092221.

4.Zhang L, Zhou S, Chen M, Yan J, Yang Y, Wu L, Jin D, Yin L,Chen M*, Qin Y*. P300-mediated NEDD4 acetylation drives ebolavirus VP40 egress by enhancing NEDD4 ligase activity.PLoS Pathogens. 2021 Jun 10;17(6): e1009616. doi: 10.1371/journal.ppat.1009616. eCollection 2021 Jun.

5.Hui X#, Zhang L#, Cao L, Huang K, Zhao Y, Zhang Y, Chen X, Lin X*,Chen M*, Jin M*. SARS-CoV-2 promote autophagy to suppress type I interferon response.Signal Transduct Target Ther. 2021 May 8;6(1):180. doi: 10.1038/s41392-021-00574-8.

6.Cheng Q, Huai W, Wu X,Chen M*. Sumoylation of Human Parainfluenza Virus Type 3 Phosphoprotein 2 Correlates with a Reduction in Viral Replication.Virol Sin. 2020. Online.

7.Wu L, Jin D, Wang D, Jing X, Gong P, Qin Y*,Chen M*. The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding.Protein Cell. 2022 2022 Feb;13(2):120-140. doi: 10.1007/s13238-020-00764-0.

8.Li Z, Guo D, Qin Y*,Chen M*. PI4KB on inclusion bodies formed by ER membrane remodeling facilitates replication of human parainfluenza virus type 3.Cell Reports. 2019. 29(8):2229-2242.

9.Zhang Q#, Sharma N#, Zheng Z*,Chen M*. Viral Regulation of RNA Granules in Infected Cells.Virol Sin. 2019 Apr;34(2):175-191.

10.Tang Q, Liu P,ChenM*, Qin Y*. 2019. Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3.Viruses. May 15;11(5).

11.Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y,Chen M*.2019.SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists.Cell Discov. eCollection.

12.Zhang L, Qin Y,ChenM*.2018. Viral strategies for triggering and manipulating mitophagy.Autophagy. 14(10):1665-1673.

13.Zhang S#, Cheng Q#, Luo C, Qin Y*,Chen M*. 2018. Human Parainfluenza Virus Type 3 Matrix Protein Reduces Viral RNA Synthesis of HPIV3 by Regulating Inclusion Body Formation.Viruses. 11;10(3).

14.Hu Z, Wang Y, Tang Q, Yang X, Qin Y,ChenM*.2018. Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs.PLoS Pathog14(3): e1006948.

15.Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, Qin Y,ChenM*.2018Picornavirus 2A protease regulates stress granule formation to facilitate viral translation.PLoS Pathog14(2): e1006901.https://doi.org/10.1371/journal.ppat.1006901.

16.Zhang S#, Cheng Q#, Luo C, Yin L, Qin Y*,ChenM*.2018. An alanine residue in human parainfluenza virus type 3 phosphoprotein is critical for restricting excessive N0-P interaction and maintaining N solubility.Virology. 518:64-76.

17.Ding B#, Zhang L#, Li Z, Zhong Y, Tang Q, Qin Y,ChenM*.2017.The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses.Cell Host & Microbe. 21(4):538-547.

18.Zhang S#, Jiang Y#, Cheng Q, Zhong Y, Qin Y,ChenM*.2017.Inclusion body fusion of human parainfluenza virus type 3 regulated by acetylated α-tubulin enhances viral replication.Journal of Virology.91(3). pii: e01802-16.

19.Jiang Y, Qin Y*,ChenM*.2016.Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.Viruses,8 (11), E308(Invited review).

20.Yan Q#, Wu L#, Chen L,Qin Y*,Pan Z*,ChenM*.2016. Vesicular stomatitis virus-based vaccines expressing EV71 virus-like particles elicit strong immune responses and protect newborn mice from lethal challenges.Vaccine. 34:4196-4204.

21.ZhangG#,ZhongY#, Qin Y,ChenM*.2015. Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly.Journal of Virology. 90(5):2306-15.

22.Ding B, Qin Y,ChenM*.2016. Nucleocapsid proteins: roles beyond viral RNA packaging.WIREs RNA. 7(2):213-26.(Invited review).

23.Chen L, Zhong Y, Hu Z, Qin Y. Chen M.ChenM*. 2016.Two second-site mutations compensate the engineered mutation of R7A in vesicular stomatitis virus nucleocapsid protein.Virus Research, 214:59-64.

24.Chen L#, Yan Q#, Lu G, Hu Z, Zhang G, Zhang S, Ding B, Jiang Y, Zhong Y, Gong P,Chen M*.2015. Several residues within the N-terminal arm of vesicular stomatitis virus nucleoprotein play a critical role in protecting viral RNA from nuclease digestion.Virology.478:9-17.

25.Ding B, Zhang G,YangX, Zhang S, Chen L,YanQ,Xu M,BanerjeeAK,ChenM*. 2014.Phosphoprotein ofhuman parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production.CellHost &Microbe.15(5):564-77.

26.ZhangG, Zhang S,DingB,YangX, Chen L,YanQ, JiangY,ZhongY,ChenM*.2014.A Leucine Residue in C-terminus ofHuman ParainfluenzaVirus Type 3Matrix Protein Is Essential for EfficientVirus-Like Particle andVirion Release.Journal ofVirology. 88(22):13173-88.

27.Zhang S, Chen L, Zhang G, Yan Q, Yang X, Ding B, Tang Q, Sun S, Hu Z,Chen M*.2013.An amino acid of human parainfluenza virus type 3 nucleoprotein is critical for template function and cytoplasmic inclusion body formation.Journal of Virology. 87(22):12457-70.

28.Chen L, Zhang S, Banerjee AK andChen M*.2013.N-Terminal Phosphorylation of Phosphoprotein of Vesicular Stomatitis Virus Is Required for Preventing Nucleoprotein from Binding to Cellular RNAs and for Functional TemplateFormation.Journal of Virology. 87(6):3177-86.

29.Chen M, Ogino T, Banerjee AK*.2007. Interaction of vesicular stomatitis virus P and N proteins: Identification of two overlapping domains at the N-terminus of P that are involved in N0-P complex formation and encapsidation of viral genome RNA.Journal of Virology.81(24):13478-85.

30.Chen M, Ogino T, Banerjee AK*.2006. Mapping and functional role of the self-association domain of vesicular stomatitis virus phosphoprotein.Journal of Virology. 80(19): 9511-8.

31.Chen Mand Gerlier D*.2006.Viral Hijacking of Cellular Ubiquitination Pathways as an Anti-Innate Immunity Strategy.Viral Immunology. 19(3): 349-362.

32.Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D*.2005. Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.Journal of Virology. 79(18): 11824-36.