基本资料
u 闵鉴，女
u 出生年月：1986.09.22
u 学历：药物化学博士，武汉大学药学院
u 目前职位：博士后研究员，美国美国伊利诺伊大学香槟分校
u 联系方式：
电话：18627717998 E-mail：jianmin@hubu.edu.cn
学习及工作简历
学习经历：
2004.09—2008.07 武汉大学药学院，理学学士，药学
2008.09—2013.12 武汉大学药学院，理学博士，生物化学与分子生物学
工作经历：
2012.02—2013.02 美国伊利诺伊大学香槟分校，访问学者
2014.11—2018.08 美国美国伊利诺伊大学香槟分校（University of Illinois at
Urbana-Champaign)，博士后研究员
2018.09—至今 湖北大学生命科学学院
参与项目
1) 国家自然科学基金重大研究计划培育项目 (No.91017005)
2) 教育部新世纪优秀人才支持计划项目(No.NCET-10-0625)
3) 国家自然科学基金面上项目(No.20872116)
4) 美国国家卫生研究所(U.S. National Institutes of Health)研究项目R01-DK015556-44
5) 美国国家卫生研究所(U.S. National Institutes of Health)研究项目R01-DK015556-43
6) 乳腺癌基金会（Breast Cancer Foundation）研究项目BCRF 17-083
博士与博士后期间发表论文
1. Jian Min, Valeria Sanabria Guillen, Abhishek Sharma, Yuechao Zhao, Yvonne Ziegler, Ping Gong, Christopher G. Mayne, Sathish Srinivasan, Sung Hoon Kim, Kathryn E. Carlson, Kendall W. Nettles, Benita S. Katzenellenbogen, and John A. Katzenellenbogen*. Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells. J. Med. Chem. 2017, 60, 6321−6336
2. Jian Min, Pengcheng Wang, Sathish Srinivasan, Jerome C. Nwachukwu, Pu Guo, Minjian Huang, Kathryn E. Carlson, John A. Katzenellenbogen*, Kendall W. Nettles, and Hai-Bing Zhou*. Thiophene-Core Estrogen Receptor Ligands Having Superagonist Activity. J. Med. Chem. 2013, 56, 3346−3366
3. Jian Min, Pengcheng Wang, Chune Dong, Haibing Zhou*. Progress in Small Molecular Inhibitors of Protein-Protein Interactions, Chinese Journal of Organic Chemistry, 2010, 30 (11), 1778-1789
4. Yuechao Zhao, Mary J. Laws, Valeria Sanabria Guillen, Yvonne Ziegler, Jian Min, Abhishek Sharma, Sung Hoon Kim, David Chu, Ben Ho Park, Steffi Oesterreich, Chengjian Mao, David J. Shapiro, Kendall W. Nettles, John A. Katzenellenbogen and Benita S. Katzenellenbogen*. Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors. Cancer Res. 2017 Oct 15;77(20):5602-5613
5. Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min, Jonna Frasor, Benita S Katzenellenbogen, Patrick R Griffin, John A Katzenellenbogen and Kendall W Nettles*. Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nat. Chem. Biol. 2017 Jan;13(1):111-118.
6. Pencheng Wang, Jian Min, Jerome C Nwachukwu, Valerie Cavett, Kathryn E Carlson, Pu Guo, Manghong Zhu, Yangfan Zheng, Chune Dong, John A. Katzenellenbogen*, Kendall W. Nettles, and Hai-Bing Zhou*. Identification and Structure-Activity Relationships of a Novel Series of Estrogen Receptor Ligands Based on 7-Thiabicyclo [2.2.1] hept-2-ene-7-oxide. J. Med. Chem., 2012, 55(5): 2324-2341.
7. Yangfan Zheng, Manghong Zhu, Sathish Srinivasan, Jerome C. Nwachukwu, Valerie Cavett, Jian Min, Kathryn E. Carlson, Chune Dong, John A. Katzenellenbogen, Kendall W. Nettles, Hai-Bing Zhou*. Development of Selective Estrogen Receptor Modulator (SERM)-Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7-Oxabicyclo[2.2.1]hept-5-ene Scaffold Core Ligands. Chem.Med.Chem. 2012 Jun;7(6):1094-100.
国际、国内会议论文
1. Jian Min, Pengcheng Wang, Chune Dong and Hai-Bing Zhou*. Design, Synthesis and Biological Evaluation of a Novel Series of Thiophenes: Ligands Selective for Estrogen Receptor β. 第七届全国有机化学学术会议, 南京, 2011年11月12-15.
2. Pengcheng Wang, Yangfan Zheng, Manghong Zhu, Liyan Ma, Jian Min, Chune Dong and Hai-Bing Zhou*. Synthesis and Biological Evaluation of Novel Estrogen Receptor Ligands with Bridged Bicyclic Core Structures. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC). February 1 to February 5, 2010, Taiwan.
国际专利
1. Antiestrogens for Cancer Therapy, 申请号PCT/US2018/024144
