宋蔚

一、基本情况

宋蔚，博士，讲师

办公电话：027-88661237

电子邮件： belinde_83(AT)163.com

研究领域：药物分析、药物代谢动力学，新药临床前研究

二、教育背景

2001.09–2005.07  湖北大学生命科学学院，生物科学专业，理学学士

2005.09–2008.07  湖北大学生命科学学院，微生物与生化药学专业，医学硕士

2009.09–2015.05  华中科技大学生命科学学院，生物制药工程专业，药学博士

三、工作经历

2016.01至今           湖北大学生命科学学院，讲师

2011.12–2012.11  美国圣母大学，访问学者

四、代表性论文（*通讯作者）：

1.      Song W, Peng Z, Gooyit M, Suckow MA, Valerie A. Schroeder VA, Wolter WR, Lee M, Ikejiri M, Cui J, Gu Z, Chang M. (2013) Water-soluble MMP-9 inhibitor prodrug generates active metabolites that cross the blood–brain barrier. ACS Chemical Neuroscience 4, 1168–1173.

2.      Song W, Yu L, Peng Z. (2015) Targeted label-free approach for quantification of epoxide hydrolase and glutathione transferases in microsomes. Analytical Biochemistry 478, 8–13.

3.      Song W, Ao M, Shi Y, Yuan L, Yuan X, Yu L. (2012) Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 85, 120–126.

4.      Song W, Peng Z, Ge B, Han F, Chen Y. (2008) Identification of metabolites of lobeline in the rat urine by liquid chromatographytandem mass spectrometry. International Journal of Mass Spectrometry 269,131–137.

5.      Major Gooyit M, Song W, Mahasenan KV, Katerina L, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. (2013) O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier. Journal of Medicinal Chemistry 56, 8139–8150

6.      O’Daniel PI, Peng Z, Pi H, Testero SA, Ding D, Spink E, Leemans E, Boudreau MA, Yamaguchi T, Schroeder VA, Wolter WR, Llarrull L, Song W, Lastochkin E, Kumarasiri M, Antunes NT, Espahbodi M, Lichtenwalter, K, Suckow MA, Vakulenko S, Mobashery S, Chang M. (2014) Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with gram-positive antibacterial activity. Journal of the American Chemical Society. 2014,

7.      Chen Y, Song W, Peng Z, Ge BY, Han F. (2008) Identification of metabolites of tectoridin in vivo and in vitro by liquid chromatography-tandem mass spectrometry. Journal of Pharmacy and Pharmacology 60, 709–716.

8.      Peng Z, Song W, Han F, Chen H, Zhu M, Chen Y. (2007) Chromatographic tandam mass spectrometric detection of papaverine and its major metabolites in rat urine. International Journal of Mass Spectrometry. 266, 114–121.

9.      Peng Z, Song W, Han F, Chen Y. (2009) In vivo and in vitro study of papaverine and its major metabolites. Acta Pharmaceutica Sinica 44, 95–100.

10.   Han FM, Peng ZH, Song W, Zhang HM, Zhu MM, Chen Y. (2007) Identification of dauricine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B 854, 1–7.

11.   Chen Y, Peng Z, Song W, Zhu MM, Han FM. (2007) Chromatographic tandem mass spectrometric detection of physostigmine and its major metabolites in rat urine. Analytical letters 40, 3256–3266.