教师信息

彭志红

作者:生命科学学院发布时间:2015年07月16日 00:00

姓名:彭志红

联系电话:18062108386

Emailzhihonpeng@hubu.edu.cn or zhihongpeng@hotmail.com


通讯地址:湖北省武汉市武昌区友谊大道368号湖北大学生命科学学院


研究领域:

药物化学,药物分析,药物代谢和药代动力学,蛋白质组学研究,新药开发和临床前研究


学习和工作简历:
20019月-20056 湖北大学生科院, 理学学士
20059月-201012月 湖北大学生科院, 理学博士
20113月-20148    University of Notre Dame  Postdoctoral Fellow

20178-201912月   University of Notre Dame  Research Scientist

20149月-今 湖北大学生科院讲师


科研项目:

(1) 国家青年基金, 81903484 基于 NQO1 激活的雷公藤甲素全新衍生物的合成及抗肝癌活性研究, 2020/01-2022/12 参与

(2) 湖北省卫计委一般面上项目,ADAM10在特发性肺纤维化中的作用研究,2017/01-2018/12,已结题,主持

(3) 湖北省教育厅青年人才项目, Q2015008,筛选与特发性肺纤维化疾病相关的解离素金属蛋白酶, 2015/01-2016/12 已结题,主持


代表性论文

2021

Peng, Z.; Nguyen, T. T.; Song, W.; Anderson, B.; Wolter, W. R.; Schroeder, V. A.; Hesek, D.; Lee, M.; Mobashery, S.; Chang, M., Selective MMP-9 inhibitor (R)-ND-336 alone or in combination with linezolid accelerates wound healing in infected diabetic mice. ACS Pharmacol. Transl. Sci. 2021, 4, 1, 107–117


2020

Qian, Y.; Allegretta, G.; Janardhanan, J.; Peng, Z.; Mahasenan, K. V.; Lastochkin, E.; Gozun, M. M. N.; Tejera, S.; Schroeder, V. A.; Wolter, W. R., Exploration of the structural space in 4 (3 H)-quinazolinone antibacterials. Journal of medicinal chemistry 2020, 63 (10), 5287-5296.

Wang, Y.; Ji, L.; Peng, Z.; Lai, R.; Zhang, X.; Xu, Y.; Chen, Z.; Liu, R.; Zhong, Y.; Hu, H., Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment. Molecular and cellular endocrinology 2020, 502, 110674.


2019

Boudreau, M. A.; Ding, D.; Meisel, J. E.; Janardhanan, J.; Spink, E.; Peng, Z.; Qian, Y.; Yamaguchi, T.; Testero, S. A.; O’Daniel, P. I., Structure–Activity Relationship for the Oxadiazole Class of Antibacterials. ACS medicinal chemistry letters 2019, 11 (3), 322-326.

Jones, J. I.; Nguyen, T. T.; Peng, Z.; Chang, M., Targeting MMP-9 in diabetic foot ulcers. Pharmaceuticals 2019, 12 (2), 79.

Nguyen, T. T.; Peng, Z.; Wolter, W. R.; Jones, J. I.; Peterson, C. E.; Mobashery, S.; Chang, M. In TARGETING MMP-9 FOR TREATMENT OF DIABETIC FOOT ULCERS, WOUND REPAIR AND REGENERATION, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: 2019; pp A35-A36.

Janardhanan J, Bouley R, Martinez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M. Intervention of allosterism in combating methicillin-resistant Staphylococcus aureus. Antimicrobial Agents Chemotherapy, 2019; 63(5): e02637-18.

Song W, Liu M, Wu J, Zhai H, Chen Y*, Peng Z*. Preclinical pharmacokinetics of triptolide: A potential antitumor drug. Current Drug Metabolism 2019,147-154.

2018

Song W, Yu L*, Peng Z*. Dataset from proteomic analysis of human liver, lung, kidney and intestine microsomes. Data in Brief. 2018; 18:831-834.

Song W, Wu J, Yu L*, Peng Z*. Evaluation of the pharmacokinetics and hepatoprotective effects of phillygenin in mouse. BioMed Research International. 2018; 2018:7964318.

Liu M, Song W, Du X, Su J, Dong K, Chen Y*, Peng Z*. An NQO1-selective activated prodrug of triptolide: Synthesis and anti-hepatocellular carcinoma activity evaluation. ACS Medicinal Chemistry Letters 2018;9(12):1253-1257.

2017

You J, Peng ZH*, Han FM*. Simultaneous determination of nine components in Gynura procumbens aqueous extract by HPLC-MS/MS. Chinese Traditional and Herbal Drugs 2017;48(2):294-298.


2016

Miao X, Wang J, Chen L, Peng Z, Chen Y. Identification of in vivo and in vitro metabolites of 4, 5-dimethoxycanthin-6-one by HPLC–Q-TOF-MS/MS. Journal of Chromatography B 2016;1020:78-84.  

Chen L, Miao X, Peng Z, Wang J, Chen Y. The pharmacokinetics and bioavailability of three canthinone alkaloids after administration of kumu injection to rats. Journal of ethnopharmacology 2016; 182:235-241.  

Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Structure–activity relationship for the 4 (3 H) quinazolinone antibacterials. Journal of Medicinal Chemistry 2016;59(10):5011-5021.  

Gooyit M, Peng Z, Mobashery S, Chang M. Thiirane class of gelatinase inhibitors as a privileged template that crosses the blood–brain barrier.  In Privileged Scaffolds in Medicinal Chemistry: Design Synthesis, Evaluation. Royal Society of Chemistry, Stefan Bräse, Ed., 2016, Chapter 10,. p. 262-286.

2015

Spink E, Ding D, Peng Z, Boudreau MA, Leemans E, Lastochkin E, Song W, Lichtenwalter K, O’Daniel PI, Testero SA, Pi, HL, Schroeder VA, Wolter W.R, Antunes NT, Suckow MA, Vakulento S, Chang M, Mobashery S. Structure–activity relationship for the oxadiazole class of antibiotics. Journal of Medicinal Chemistry 2015;58(3):1380-1389.  

Song W, Yu L*, Peng Z*. Targeted label-free approach for quantification of epoxide hydrolase and glutathione transferases in microsomes. Analytical Biochemistry 2015; 478:8-13.  

Semple BD, Noble-Haeusslein LJ, Gooyit M, Tercovich KG, Peng Z, Nguyen TT, Schroeder VA, Suckow MA, Chang M, Raber J, Trivedi A. Early gelatinase activity is not a determinant of long-term recovery after traumatic brain injury in the immature mouse. PloS One 2015;10(11):e0143386.  

Wang H, Lee M, Peng Z, Blázquez B, Lastochkin E, Kumarasiri M, Bouley R, Chang M, Mobashery S. Synthesis and evaluation of 1, 2, 4-triazolo [1, 5-a] pyrimidines as antibacterial agents against Enterococcus faecium. Journal of Medicinal Chemistry 2015;58(10):4194-4203.

Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi HL, Vakulento S, Hermoso JA, Chang M, Mobashery S. Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl) quinazolin-4 (3 H)-one. Journal of the American Chemical Society 2015;137(5):1738-1741.  


专利:

1. 宋蔚,彭志红,刘媚琳,张雪珂,杜茜,陈勇。一种雷公藤甲素衍生物及其制备方法和用途。 授权专利号:ZL201710358992.9.

2. 彭志红,刘媚琳, 杨雁羽,杜茜, 宋蔚, 陈勇. 一种水溶性雷公藤甲素衍生物及其制备方法和用途。申请号: 201910325154.0


指导学生创新实践:

12020年指导学生获批第五届全国大学生生命科学创新创业大赛二等奖,获指导教师二等奖

2. 2020年湖北省创新创业训练计划项目 (S202010512065),指导教师

3. 2019年指导学生获批第四届全国大学生生命科学创新创业大赛二等奖,获指导教师二等奖

4. 2019年指导学生获湖北省第五届大学生生物实验技能竞赛获三等奖,获优秀指导教师奖

5. 2018年指导学生获批第三届全国大学生生命科学创新创业大赛二等奖,获指导教师二等奖