彭志红

一、基本情况

彭志红，博士，讲师

电子邮箱：zhihonpeng(AT)hubu.edu.cn or zhihongpeng(AT)hotmail.com

研究领域：药物化学，药物分析，药物代谢和药代动力学，蛋白质组学研究，新药开发和临床前研究

二、教育背景

2005.09–2010.12  湖北大学生命科学学院，理学博士

2001.09–2005.06  湖北大学生命科学学院，理学学士
三、工作经历

2014.09至今          湖北大学生命科学学院，讲师

2017.08–2019.12  美国圣母大学，研究科学家

2011.03–2014.08  美国圣母大学，博士后

四、科研项目

1.     国家青基金（81903484）：基于NQO1激活的雷公藤甲素全新衍生物的合成及抗肝癌活性研究，2020.01–2022.12，参与

2.     湖北省卫计委一般面上项目：ADAM10在特发性肺纤维化中的作用研究，2017.01–2018.12，主持

3.     湖北省教育厅青人才项目，Q2015008，筛选与特发性肺纤维化疾病相关的解离素金属蛋白酶，2015.01–2016.12，主持

五、代表性论文：

1.      Peng Z. Nguyen TT, Song W, Anderson B, Wolter WR, Schroeder VA, Hesek, D, Lee M, Mobashery S. Chang M. (2021) Selective MMP-9 inhibitor (R)-ND-336 alone or in combination with linezolid accelerates wound healing in infected diabetic mice. ACS Pharmacology & Translational Science 1, 107–117

2.      Qian Y, Allegretta G, Janardhanan J, Peng Z, Mahasenan KV, Lastochkin E, Gozun MMN, Tejera S, Schroeder VA, Wolter WR. (2020) Exploration of the structural space in 4 (3 H)-quinazolinone antibacterials. Journal of Medicinal Chemistry 63, 5287–5296.

3.      Wang Y, Ji L, Peng Z, Lai R, Zhang X, Xu Y, Chen Z, Liu R, Zhong Y, Hu H. (2020) Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment. Molecular and Cellular Endocrinology 2020, 502, 110674.

4.      Boudreau MA, Ding D, Meisel JE, Janardhanan J, Spink E, Peng Z, Qian Y, Yamaguchi T, Testero SA, O’Daniel PI. (2019) Structure-activity relationship for the oxadiazole class of antibacterials. ACS Medicinal Chemistry Letters 11, 322–326.

5.      Jones JI. Nguyen TT. Peng Z. Chang M. (2019) Targeting MMP-9 in diabetic foot ulcers. Pharmaceuticals 12, 79.

6.      Nguyen TT, Peng Z, Wolter WR, Jones JI, Peterson CE, Mobashery S, Chang, M. (202) In TARGETING MMP-9 FOR TREATMENT OF DIABETIC FOOT ULCERS, WOUND REPAIR AND REGENERATION, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2019 pp A35–A36.

7.      Janardhanan J, Bouley R, Martinez–Caballero S, Peng Z, Batuecas–Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M. (2019) Intervention of allosterism in combating methicillin-resistant Staphylococcus aureus. Antimicrobial Agents Chemotherapy 63, e02637–18.

8.      Song W, Liu M, Wu J, Zhai H, Chen Y*, Peng Z*.(2019) Preclinical pharmacokinetics of triptolide, a potential antitumor drug. Current Drug Metabolism 20, 147–154.

9.      Song W, Yu L*, Peng Z*. (2018) Dataset from proteomic analysis of human liver, lung, kidney and intestine microsomes. Data in Brief 18, 831–834.

10.   Song W, Wu J, Yu L*, Peng Z*. (2018) Evaluation of the pharmacokinetics and hepatoprotective effects of phillygenin in mouse. BioMed Research International 2018, 7964318.

11.   Liu M, Song W, Du X, Su J, Dong K, Chen Y*, Peng Z*. (2018) An NQO1-selective activated prodrug of triptolide, Synthesis and anti-hepatocellular carcinoma activity evaluation. ACS Medicinal Chemistry Letters 9, 1253–1257.

12.   You J, Peng ZH*, Han FM*. (2017)Simultaneous determination of nine components in Gynura procumbens aqueous extract by HPLC-MS/MS. Chinese Traditional and Herbal Drugs 48, 294–298.

13.   Miao X, Wang J, Chen L, Peng Z, Chen Y. (2016) Identification of in vivo and in vitro metabolites of 4, 5-dimethoxycanthin-6-one by HPLC-Q-TOF-MS/MS. Journal of Chromatography B 1020, 78–84.

14.   Chen L, Miao X, Peng Z, Wang J, Chen Y. (2016) The pharmacokinetics and bioavailability of three canthinone alkaloids after administration of kumu injection to rats. Journal of ethnopharmacology 182, 235–241.  

15.   Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. (2016) Structure-activity relationship for the 4 (3 H) quinazolinone antibacterials. Journal of Medicinal Chemistry 59, 5011–5021.

16.   Gooyit M, Peng Z, Mobashery S, Chang M. (2016) Thiirane class of gelatinase inhibitors as a privileged template that crosses the blood–brain barrier. In Privileged Scaffolds in Medicinal Chemistry, Design Synthesis, Evaluation. Royal Society of Chemistry, Stefan Bräse, Ed., Chapter 10, 262–286.

17.   Spink E, Ding D, Peng Z, Boudreau MA, Leemans E, Lastochkin E, Song W, Lichtenwalter K, O’Daniel PI, Testero SA, Pi, HL, Schroeder VA, Wolter W.R, Antunes NT, Suckow MA, Vakulento S, Chang M, Mobashery S. (2015) Structure-activity relationship for the oxadiazole class of antibiotics. Journal of Medicinal Chemistry 58, 1380–1389.

18.   Song W, Yu L*, Peng Z*. (2015) Targeted label-free approach for quantification of epoxide hydrolase and glutathione transferases in microsomes. Analytical Biochemistry 478, 8–13.

19.   Semple BD, Noble–Haeusslein LJ, Gooyit M, Tercovich KG, Peng Z, Nguyen TT, Schroeder VA, Suckow MA, Chang M, Raber J, Trivedi A. (2015) Early gelatinase activity is not a determinant of long-term recovery after traumatic brain injury in the immature mouse. PLoS One 10, e0143386.

20.   Wang H, Lee M, Peng Z, Blázquez B, Lastochkin E, Kumarasiri M, Bouley R, Chang M, Mobashery S. (2015) Synthesis and evaluation of 1, 2, 4-triazolo [1, 5-a] pyrimidines as antibacterial agents against Enterococcus faecium. Journal of Medicinal Chemistry 58, 4194–4203.

21.   Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi HL, Vakulento S, Hermoso JA, Chang M, Mobashery S. (2015) Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl) quinazolin-4 (3 H)-one. Journal of the American Chemical Society 137, 1738–1741.

六、专利：

1.     宋蔚，彭志红，刘媚琳，张雪珂，杜茜，陈勇。一种雷公藤甲素衍生物及其制备方法和用途。授权专利号：ZL201710358992.9.

2.     彭志红，刘媚琳，杨雁羽，杜茜，宋蔚，陈勇. 一种水溶性雷公藤甲素衍生物及其制备方法和用途。申请号：201910325154.0 。

七、指导学生创新实践：

1.    2020指导学生获批第五届全国大学生生命科学创新创业大赛二等奖，获指导教师二等奖

2.    2020湖北省创新创业训练计划项目（S202010512065），指导教师

3.    2019指导学生获批第四届全国大学生生命科学创新创业大赛二等奖，获指导教师二等奖

4.    2019指导学生获湖北省第五届大学生生物实验技能竞赛获三等奖，获优秀指导教师奖

5.    2018指导学生获批第三届全国大学生生命科学创新创业大赛二等奖，获指导教师二等奖