副教授

刘奕

发布时间:2019-05-20    点击率:

姓  名: 刘奕

电子邮件: yiliu0825@hubu.edu.cn

通讯地址: 湖北省武汉市武昌区友谊大道368号湖北大学生命科学学院

研究领域:化学生物学、金属蛋白酶作用机理、基因编辑酶的开发和利用、纳米生物医学

一、学习和工作简历

  • 2003.9-2007.7 湖北大学化学生物学国家理科基地班理学学士

  • 2007.9-2012.7 复旦大学化学生物学专业理学博士生(硕博连读)

  • 2012.8-2014.9 美国约翰霍普金斯大学化学系博士后

  • 2014.9-2015.10 美国达特茅斯学院化学系博士后

  • 2015.12-2016.10 上海大学环境科学学院纳米化学与生物学研究所

  • 2016.12-2017.7 湖北大学生命科学学院讲师

  • 2017.7-至今 湖北大学生命科学学院副教授

二、承担科研项目情况

1. 湖北省自然科学基金(201700963)

2. 湖北大学专项启动经费

三、代表性论文(*通讯作者)

1. Qiao Jie, Jie Qiao, Lixin Ma, Justine Roth, Yamin Li, and Yi Liu*, Kinetic basis for the activation of human cyclooxygenase-2 rather than cyclooxygenase-1 by nitric oxide, Org. Biomol. Chem., (2018), 16: 765–770

2. Yi Liu*, Aoneng Cao*. Encapsulating Proteins in Nanoparticles: batch by batch or one by one. Methods in Enzymology, (2017), 590:1-31

3. Yi Liu, Justine Roth*. A revised mechanism for human cyclooxygenase-2. J. Bio. Chem., (2016), 291: 948-958.
4. Yi Liu, Arnab Mukherjee, Nadav Nahumi, Mehmet Ozbil, Doreen Brown, Alfredo M. Angeles-Boza, David Dooley*, Rajeev Prabhakar*, and JustineRoth*. Experimental and computational evidence of metal-O2activation and rate-limiting proton-coupled electron transfer in a copper amine oxidase. J. Phys. Chem. B., (2013), 117: 218–229.

5. Yi Liu, Qingli Wang, Yaozhu Wei, Ying-Wu Lin, Wei Li, Ji-Hu Su, Zheng Wang, Yang Tian, Zhong-Xiang Huang and Xiangshi Tan*. Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase. Chem. Commun., (2013), 49: 1452-1454.

6. Yi Liu, Wei Li, Yaozhu, Wei, Yingdi Jiang and Xiangshi Tan* Efficient preparation and metal specificity of the regulatory protein TroR from the human pathogen Treponema pallidum.Metallomics, (2013), 10: 1448-1457

7. Yi Liu, Feng Wang, Pingwei Li and Xiang-Shi Tan*. Insights into the mechanistic role of the [Fe4S4] cubane in the A-cluster {[Fe4S4]-(SR)-[NipNid]} of acetyl-coenzyme A synthase . ChemBioChem, (2011), 12: 1417-1421.

8. Yi Liu, Xiaofeizhu, Feng Wang, Tianlei Ying, Pingwei Li, Zhong-xian Huang and Xiangshi Tan*. Probing the role of the bridging C509 between the [Fe4S4] cubane and the [NipNid] center in the A-cluster of acetyl-coenzyme A synthase. Chem. Commun., (2010), 47: 1291-1293.

9. Yi Liu, Xiangshi Tan*. Progress in EPR-based studies on carbon monoxide dehydrogenase/acetyl-coenzyme A synthase. (Review) Chinese Journal of Magnetic Resonance, (2011), 4: 490-501.

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