陈勇

一、基本信息

陈勇，博士，二级教授、博士研究生导师、湖北大学中药生物技术省重点实验室主任、药物高通量筛选省工程实验室主任、生物医药研究生教育省创新基地主任，以及微生物与生化药学省重点学科负责人

办公电话：027-88661237-8046

电子邮件：cy101610(AT)yahoo.com

社会兼职：药学学报、中草药、应用基础与工程科学学报、中华现代中医学杂志等刊物编委，全国有机分析专业委员会理事

研究领域：主要从事分子药理学和药代动力学研究

二、教育背景

1990.08–1993.12  北京大学化学与分子工程学院，博士

1987.09–1990.07  武汉大学化学系三制，硕士

1983.09–1987.07  武汉大学化学系四制，学士

三、工作经历

1995.12至今           湖北大学生命科学学院教授、博士生导师

1993.12–1995.11  中科院研究生院化学部博士后

四、科研项目

1.      杜仲叶、山麦冬标准提取物研究。01年武汉市科委重大科技攻关项目（50万，No.20016001008），主持人

2.      指纹图谱应用示范研究。科技部十五攻关项目（中医药现代化研究与产业化开发）（程翼宇主持，No.2001BA701A01），联合申报单位负责人（分配经费10万）

3.      中药标准提取物及其指纹图谱研究。湖北省青年杰出人才科学基金（10万，No.2002AC004），主持人

4.      慢性肝炎中医“证”分型的分子基础研究。国家重大基础研究前期专项（30万，No.2002ccc00300），主持人

5.      用于中药临床前安全性评价的毒理芯片开发研究。湖北省科技厅（6万，No.2004AA303B05）和武汉市科技局重点攻关项目（10万，No.20036003042），主持人

6.      确有疗效复方中药痹祺胶囊的药代动力学研究。07年国家自然科学基金重点项目（刘昌孝院士主持，No.30630075），联合申报单位主持人（分配经费35万）

7.      复方脉君安片的药动学与分子药理学研究。湖北省高等学校优秀中青年团队计划项目（32万，No.T200807），主持人

8.      浓缩型脉君安片临床前研究。湖北省发改委生物产业专项项目（No.鄂发改高技  [2008] 1365号–1，40万），主持人

9.      抗乙肝病毒药物筛选关键技术。湖北省发改委生物产业专项项目（湖北省生物产业专项，No.鄂发改投资[2009]1734号，50万），主持人

10.   与乙型病毒性肝炎病毒生活周期相关的细胞因子或靶分子。艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项课题（吴建国主持，No.2008ZX10204），联合申报单位负责人（分配经费20万）

五、发表论文

1.      Liang J, Liu C, Qiao A, Cui Y, Zhang H, Cui A, Zhang S, Yang Y, Xiao X, Chen Y, Fang F, Chang Y. (2013) MicroRNA-29a-c decrease fasting blood glucose levels by negatively regulating hepatic gluconeogenesis. Journal of Hepatology 58, 535–542.

2.      Peng ZH, Wang ZJ, Du P, Chen Y. (2012) Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 70, 624–630.

3.      Liang J, Han F, Chen Y. (2012) An electrochemical method for high sensitive detection of nicotine and its interaction with bovine serum albumin. Electrochemistry Communications 24, 93–96.

4.      Chen XM, Wei M, Zhang HM, Luo CH, Chen YK, Chen Y. (2012) Effect of vanillin and ethyl vanillin on Cytochrome P450 activity in vitro and in vivo.  Food and Chemical Toxicology 50, 1897–1901.

5.      Yi M, Peng W, Chen X, Wang J, Chen Y. (2012) Effect of hypaconitine combined with liquiritin on the expression of Calmodulin and Connexin43 in rat cardiac muscle in vivo. Journal of Pharmacy and Pharmacology. 64, 1654–1658.

6.      Liu L, Xiao J, Peng ZH, Wu W, Du P, Chen Y. (2012) In vitro metabolism of strychnine by human cytochrome P450 and its interaction with glycyrrhetic acid. Chinese Herbal Medicines 4, 118–125.

7.      Liu L, Xiao J, Peng Z, Chen Y. (2011) In vitro metabolism of glycyrrhetic acid by human cytochrome P450. Acta Phamaceutica Sinica 46, 81–87

8.      Xing PP, Wu W, Du P, Han FM, Chen Y. (2011) Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo. Acta Pharmaceutica Sinica 46, 573–580.

9.      Gao Q, Wang J, Han FM, Chen Y. (2011) Effect of strychnine hydrochloride on liver cytochrome P450 mRNA expression and monooxygenase activities in rat. Acta Pharmaceutica Sinica B 1, 121–128.

10.   Qiao A, Liang J, Ke Y, Li C, Cui Y, Shen L, Zhang H, Cui A, Liu X, Liu C, Chen Y, Zhu Y, Guan Y, Fang F, Chang Y. (2011) Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis. Hepatology 54, 509–521.

11.   Han FM, Zhu MM, Chen HX, Chen Y (2010). Identification of sophoridine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Analytical Letters 43, 45–54

12.   Zhu LL, Liu Y, Cui AF, Shao D, Liang JC, Liu XJ, Chen Y, Gupta N, Fang FD, Chang Y. (2010) PGC-1α coactivates estrogen-related receptor-α to induce the expression of glucokinase. American Journal of Physiology-Endocrinology and Metabolism 298, 1210–E1218.

13.   Kong X, Wang R, XueY, Liu X, Zhang H, Chen Y, Fu F, Chang Y. (2010) Sirtuin 3, a new target of PGC-1a, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One 5, 1–13

14.   Yang QC, Han FM, Xiong YQ, Xing PP, Chen Y. (2010) The metabolism of glycyrrhetic acid in rat liver microsomes and in vitro metabolic interaction with six CYP450 probe substrates. Asian Journal of Pharmacodynamics and Pharmacokinetics 10, 310–319

15.   Qian C, Yang QC, Wu WH, Han F, Chen Y. (2009) Identification of in vivo and in vitro metabolites of palmatine by liquid chromatography-tandem mass spectrometry. Journal of Pharmacy and Pharmacology 61, 647–652

16.   Kong X, Fan H, Liu X, Wang R, Liang J, Gupta N, Chen Y, Fang F, Chang Y. (2009) Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5′-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Molecular Pharmacology 76, 854–860

17.   Peng ZH, Song W, Han FM, Chen Y. (2009) In vivo and in vitro study of papaverine and its major metabolites. Acta Phamaceutica Sinica 2009, 95–100

18.   Han FM, Yang QC, Du P, Wu WH, Chen Y. (2009) The metabolism of strychnine in rat liver microsomes and metabolic interaction with glycyrrhetic acid in vitro. Asian Journal of Pharmacodynamics and Pharmacokinetics, 2009, 9, 301–312

19.   Chen Y, Song W, Peng ZH, Ge BY, Han FM. (2008) Identification of metabolites of tectoridin in vivo and in vitro by liquid chromatography- tandem mass spectrometry. Journal of Pharmacy and Pharmacology 0, 1–8

20.   Zhang Y, Wu W, Han F, Chen Y. (2008) LC/MS/MS for identification of in vivo and in vitro metabolites of jatrorrhizine. Biomedical Chromatography, 22, 1360–1367.

21.   Chen HX, Chen Y, Du P, Han FM. (2007) LC-MS for identification and elucidation of the structure of in-vivo and in-vitro metabolites of atropine. Chromatographia 2007, 65, 413–418

22.   Zhu M, Han F, Chen H, Peng Z, Chen Y. (2007) Identification of palmatine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Rapid Communications in Mass Spectrometry 21, 2019–2022.

23.   Chen Y, Zhang XM, Han FM, Du P, Xia QS. (2007) Gene expression profiling analyses of injured mice livers by Leigongteng (Tripterygium Wilfordii Hook. f.). World Journal of Gastroenterology 13, 3619–3624.

24.   Han FM, Peng ZH, Song W, Zhang HM, Zhu MM, Chen Y. (2007) Identification of dauricine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B 854, 1–7

25.   Chen H, Chen Y, Du P, Han F. (2007) Structural elucidation of in-vivo and in-vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis., 44(3), 773–778

26.   Chen Y, Peng ZH, Zhu MM, Han FM. (2007) Chromatographic tandem mass spectrometric detection of papaverine and its major metabolites in rat urine. International Journal of Mass Spectrometry 266, 114–121.

27.   Ge BY, Chen HX, Han FM, Chen Y. (2007) Identification of amygdalin and its major metabolites in rat urine by LC-MS/MS. Journal of Chromatography B  857, 281–286

28.   Song W, Peng Z, Ge B, Han F, Chen Y. (2007) Identification of metabolites of lobeline in the rat urine by liquid chromatography-tandem mass spectrometry. International Journal of Mass Spectrometry 269, 131–137.

29.   Chen Y*, Peng ZH, Song W, Zhu MM, Han FM. (2007) Chromatographic tandem mass spectrometric detection of physostigmine and its major metabolites in rat urine. Analytical Letters 40, 3256–3266.

30.   Han FM, Cheng M, Xia QS, Chen Y. (2006) Gene expression profile in immunologically injured liver cell of mice. Science in China Series C-Life Sciences 49, 454–459

31.   Zhu MM, Chen HX, Han FM, Chen Y. (2006) Analysis of arecoline and identification of its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Chromatographia 64, 705–708

32.   Chen H, Chen Y, Du P, Han F, Wang H, Zhang H. (2006) Sensitive and specific liquid chromatographic-tandem mass spectrometric assay for atropine and its eleven metabolites in rat urine. Journal of Pharmaceutical and Biomedical Analysis 40, 142.

33.   Chen H, Chen Y, Wang H, Du P, Han F, Zhang H. (2005) Analysis of scopolamine and its eighteen metabolites in rat urine by LC tandem mass spectrometry. Talanta 67, 984–991

34.   Chen H, Wang H, Chen Y, Zhang H. (2005) Liquid chromatography-tandem mass spectrometry analysis of anisodamine and its phase I and II metabolites in rat urine. Journal of Chromatography B 824, 21–29.

35.   Chen Y, Chen H, Du P, Han F, Zhang H. (2005) The Analysis of anisodine and the identification of twenty of its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Chromatographia 62, 563–569.

六、授权发明专利

1.     陈勇，李紫，蔡敏。山麦冬多糖提取工艺。发明专利，专利号ZL 02147758.2

2.     韩凤梅，杜鹏，郭小龙，陈勇。一种以枸杞酒渣为原料制备高免疫调节活性枸杞多糖的酶解工艺。发明专利，专利授权号ZL 200710052400.7

3.     陈勇，韩凤梅，张继业，张仙，王恒松。一种服用剂量小的浓缩型脉君安片或胶囊配方及其制备方法。发明专利，专利授权号ZL 200810048199.X