教授

余晓岚

发布时间:2018-03-01    点击率:

 

 

 

 

姓  名: 余晓岚

办公电话: 027-88661237-807113476094548(手机)

电子邮件: yxiaolan@163.com

通讯地址: 湖北省武汉市武昌区友谊大道368号湖北大学生命科学学院

任职情况:博士,现任湖北大学教授,博士、硕士研究生导师

社会兼职:中国中国微生物学会会员、湖北省微生物学会会员、湖北省免疫学

会理事、武汉市免疫学会理事

研究领域:动物新型疫苗、蛋白表达研究、病毒表观遗传

一、学习和工作简历:

l 19969-20007月,华中农业大学动物科学学院,获农学学士学位

l 20009-20057月,华中农业大学动物医学学院,获农学博士学位

l 20123-20129月,美国凯斯西储大学,访问学者

l 20131-20141月,美国凯斯西储大学,Associate Research

l 20152-20155月,美国凯斯西储大学,博士后

l 2005-今,湖北大学生命科学学院讲师、副教授、教授

二、承担科研项目情况:

1. 国家自然科学基金(31672561):展示靶向单链抗体(scFv)的细菌膜影(ghost)递送线性DNA疫苗的分子机制研究;2017,1-2020,12,主持人。

2. 国家自然科学基金(31340036):基于酿酒酵母靶向性递呈和表达的DNA疫苗研究;2014.1- 2014.12,主持人。

3. 国家自然科学基金(31172320):基于大规模PCR技术高通量制备DNA疫苗方法的研究

2012.1-2015.12,主持人。

4. 国家自然科学基金(30801008):SPOPMyD88的相互作用调控TLR信号途径的分子机理研究2009.1-2011.12,主持人。

5. 武汉市青年科技晨光计划(201050231086)基于家蚕重组杆状病毒的高效蛋白表达系统的研究2010.1-2012.12,主持人。

6. 湖北省教育厅重点项目(D20111005)基于大规模PCR技术线性DNA疫苗的研究2011.1- 2012.12,主持人。

7. 湖北省教育厅-湖北省高等学校青年教师深入企业行动计划项目(XD2010118)猪用干扰素发酵中试放大研究,2011.1-2011.12,主持人。

8. 湖北省自然科学基金(2008CDB11)SPOPMyD88的相互作用调控TLR信号途径的研究2009.1-2010.12,主持人。

9. 国家微生物重点实验室开放基金,AML-0801,基于口蹄疫病毒(FMDVP1 DNA疫苗及牛疱疹病毒VP22蛋白的佐剂作用的研究,2008.9-2010.8,主持人。

三、代表性论文(*通讯作者):

1. Fei Wang, Quanjiao Chen, Shuntang Li, Chenyao Zhang, Shanshan Li, Min Liu, Kun Mei, Chunhua Li, Lixin Ma, Xiaolan Yu*. Linear DNA vaccine prepared by large-scale PCR provides protective immunity against H1N1 influenza virus infection in mice. Vet Microbiol, 2017, 205:124-130

2. Xiaolan Yu, Jingfeng Sha, Shao Xiang, Sanhai Qin, Patricia Conrad, Santosh K. Ghosh, Aaron Weinberg, Fengchun Ye. Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth. Cell Cycle, 2016, 15(15):2053-2065.

3. Xiaolan Yu, Abdel-Malek Shahir, Jingfeng Sha, Zhimin Feng, Betty Eapen, Stanley Nithianantham, Biswajit Das, Jonathan Karn, Aaron Weinberg, Nabil F. Bissada, Fengchun Ye. Short chain fatty acids from periodontal pathogens suppress HDACs, EZH2, and SUV39H1 to promote Kaposi's Sarcoma-Associated Herpesvirus replication. J Virol, 2014, 88(8):4466-4479,

4. Xilan Yu, Wuxiang Mao, Yansheng Zhai, Chong Tong, Min Liu, Lixin Ma, Xiaolan Yu*, Shanshan Li. Anti-tumor activity of metformin: from metabolic and epigenetic perspectives. Oncotarget, 2017, 8(3):5619-5628

5. Fei Wang, Shuntang Li, Hui Zhao, Lu Bian, Liang Chen, Zhen Zhang, Xing Zhong, Lixin Ma, Xiaolan Yu*. Expression and Characterization of the RKOD DNA Polymerase in Pichia pastoris. PLoS One, 2015, 10(7): e0131757.

6. Kun Mei, Guang Liu, Zhenzhen Chen, Zhimin Gao, Lihua Zhao, Tao Jin, Xiaolan Yu*, Quanjiao Chen. Deep sequencing reveals the viral adaptation process of environment -derived H10N8 in mice. Infect Genet Evol. 2016, 37:8-13.

7. Meng Li, Xiaolan Yu, Fei Wang, Chao Zhai, Wei Shen, Xianhong Yu, Xiaojuan Wang , Lixin Ma.(共同第一作者)Secretory expression of organophosphorus hydrolase OPHC2 in Yarrowia lipolytica Polg. J Environ Sci Heal B. 2015, 50(10):691-697.

8. Xiaolan Yu, Junqing Hua, Guibin Hu, Jie Zhang, Lixin Ma. Expression of recombinant protein in insect cells by their direct infection with Escherichia coli transformed with baculovirus bacmids. Acta Virol, 2014, 58:61-68.

9. Xiaolan Yu, Shaobo Xiao, Liurong Fang, Yunbo Jiang, Huanchun Chen, Meilin Jin. A DNA vaccine encoding the FMDV capsid precursor polypeptide P1 and the enhancing effect of bovine herpesvirus 1 VP22 protein as molecular adjuvant. Acta Virol, 2012, 56(2):111-117.

10. Xiaolan Yu, Shaobo Xiao, Liurong Fang, Yunbo Jiang, Huanchun Chen. Enhanced immunogenicity to foot-and-mouth disease virus in mice vaccination with alphviral replicon-based DNA vaccine expressing the capsid precursor polypeptide (P1). Vrius Genes, 2006, 33:337-344.

11. Natarajan Bhaskaran, Santosh K. Ghosh, Xiaolan Yu, Sanhai Qin, Aaron Weinberg, Pushpa Pandiyan, Fengchun Ye. Kaposi's sarcoma-associated herpesvirus infection promotes differentiation and polarization of monocytes into tumor-associated macrophages. Cell Cycle, 2017, 16(17):1611-1621

12. Qi Yu, Chong Tong, Mingdan Luo, Xiangyan Xue, Qianyun Mei, Lixin Ma, Xiaolan Yu, Wuxiang Mao, Lingbao Kong, Xilan Yu, Shanshan Li. Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites. PLoS One, 2017, 12(4):e0175576.

13. Fei Wang , Xiaojuan Wang , Xiaolan Yu , Ling Fu , Ying Liu , Lixin Ma , Chao Zhai . High-Level Expression of Endo-β-N-Acetylglucosaminidase H from Streptomyces plicatus in Pichia pastoris and Its Application for the Deglycosylation of Glycoproteins. PLoS One. 2015, 10(9):e013792.

14. Yuhai Bi, Kun Mei, Weifeng Shi, Di Liu, Xiaolan Yu, Zhimin Gao, Lihua Zhao, George F Gao, Jianjun Chen, Quanjiao Chen. Two novel reassortants of avian influenza A (H5N6) virus in China. J Gen Virol, 2015, 96(Pt 5):975-81.

15. Biswajit Das, Curtis Dobrowolski, Abdel-Malek Shahir,Zhimin Feng, Xiaolan Yu, Jinfeng Sha, Nabil F. Bissada, Aaron Weinberg, Jonathan Karn,Fengchun Ye. Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications. Virology. 2015, 474:65-81

16. Xing Zhong, Chao Zhai, Dengxiang Yang, Sijing Jiang, Zhezhe Li, Xiaolan Yu, Liang Chen, Zhen Zhang, Fei Wang, Yaping Wang, Wanping Chen, Lixin Ma. A single-step mixing cloning method for assembly of lentiviral short hairpin RNA expression vectors for gene silencing. alytical Biochemistry 2013, 438:39–41

17. Fengchun Ye, Fuchun Zhou, Santosh Nithianantham, Chandran B, Xiaolan Yu, Weinberg Aaron, Shoujiang Gao. Kaposi’s Sarcoma-Associated Herpesvirus Induces Rapid Release of Angiopoietin-2 from Endothelial Cells. J Virol, 2013, 87(11):6236-6335.

18. Xiaomei Chen, Chao Zhai, Lixin Kang, Chunhua Li, Hong Yan, Yulin Zhou, Xiaolan Yu, Lixin Ma. High-level expression and characterization of a highly thermostable chitosanase from Aspergillus fumigatus in Pichia pastoris. Biotechnol Lett, 2012, 34:689–694

19. Jinrong Fu, Guosheng Lin, Bin Zeng, Zhiwei Wu, Yanxia Wu, Honggang Chu, Gangjian Qin, Gong Liang, Jinan Li, Xiang Gan, Xiaolan Yu, Chunhua Li, Dongxu Liu. Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. BBRC, 2006, 350(1):162-168.

20. Yunbo Jaing, Shaobo Xiao, Liurong Fang, Xiaolan Yu, Yunfeng Song, Chuanshuang Niu, Huanchun Chen. DNA vaccines co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus (PRRSV) display enhanced immunogenicity. Vaccine, 2006, 24(5):2869-2879.

21. Lin Yan, Qigai He, Xiaolan Yu, Weicheng Bei, Huanchun Chen. The co-administrating of recombinant porcine IL-2 could enhance protective immune responses to PRV inactivated vaccine in pigs. Vaccine. 2005, 23(35):4436-4441.

四、专利

1. 一种耐高温壳聚糖酶酵母工程菌及其耐高温壳聚糖酶的生产方法,2013.5.22,中国,ZL201010507427.2

2. 一种高通量的通过细菌直接侵染将外源基因导入昆虫细胞的方法,2011.1,中国,ZL200710052967.4

3. 一种利用毕赤酵母高效表达DNA聚合酶的方法,2012.10,中国,ZL201010229160.5

4. 一种快速高校构建高效构建哺乳动物细胞RNA干扰载体及其验证载体的方法,2011.4,中国,ZL200710052912.3

5. 一种简单高效制备纯化TaqDNA聚合酶的方法,2012.5,中国,ZL201210165241.2

五、获奖

1. 2018年湖北省自然科学二等奖2018.8,湖北省人民政府

2. 2016湖北省科学技术发明奖二等奖,2016.12,湖北省人民政府

3.指导学生获得第四届湖北省高等学校大学生生物实验技能竞赛综合赛一等奖,2016.8,湖北省教育厅。

4.指导学生获得湖北省优秀学士学位论文,2012.12,湖北省教育厅

六、人才荣誉

获批2018年武汉东湖高新区第十一批“3551光谷人才计划” 2018.12

 

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