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  • 李珊珊
  • 作者:系统管理员    发布日期:2016-03-18    点击率:
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    姓  名: 李珊珊
    办公电话: 027-88661237-8035 
    电子邮件: shanshanyxl@hotmail.com 
    通讯地址: 湖北省武汉市武昌区友谊大道368号湖北大学生命科学学院
    基本情况:博士,教授、湖北省“百人计划”入选者,“楚天学者”楚天学子
    研究领域:表观遗传学
     
    学习和工作简历
    2000/09–2004/06,  华中农业大学,生命科学技术学院,学士
    2004/09–2006/06,  武汉大学,微生物学,硕士
    2006/08–2010/12,  美国爱荷华州立大学,分子细胞发育生物学,博士
    2011/01–2013/08,  美国爱荷华州立大学,微生物学,博士后
    2013/08–2015/11,  美国斯托瓦斯医学研究所,博士后
    2015/12-至今,     湖北大学,生命科学学院,特聘教授
     
    承担科研项目情况
    (1) 生物资源绿色转化湖北省协同创新中心:专项启动经费,400万,2015.12-2018.12,主持
    (2) 中国国家自然科学基金,31460667,乙脑病毒激活内质网应激反应的分子机制及致病性研究,50万,2015/01-2018/12,参与。
    (3) 中国国家自然科学基金,31160034,内质网应激反应和丙肝病毒NS4B致病性研究,50万,2011/01-2015/12,已结题,参与。
    (4) 美国国家自然科学基金,MCB-0920156,Cellular responses to quaternary ammonium compounds by Pseudomonas syringae that influence its interactions with plants,57万美元,2011/01-2013/12,已结题,参与。
    (5) 美国国立卫生院基金,GM79663,Histone Modifications and Higher-Order Chromatin Structure,160万美元,2007/01-2010/12,已结题,参与。
     
    代表性研究成果
    (1) Shanshan Li, Selene K. Swanson, Madelaine Gogol, Laurence Florens, Michael P. Washburn, Jerry L. Workman, Tamaki Suganuma*. Serine and SAM responsive complex SESAME regulates histone modification crosstalk by sensing cellular metabolism. Mol Cell 2015, 60(3):408-21. 
    (2) Shanshan Li and Michael A. Shogren-Knaak*. Cross-talk between histone H3 tails produces cooperative nucleosome acetylation. Proc Natl Acad Sci U S A. 2008, 105(47):18243-18248. 
    (3) Shanshan Li and Michael A. Shogren-Knaak*. The Gcn5 bromodomain of the SAGA complex facilitates cooperative and cross-tail acetylation of nucleosomes. J Biol Chem 2009, 284(14), 9411-9417. 
    (4) Shanshan Li#,*, Lingbao Kong#,*, Xilan Yu. The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis. Crit Rev Microbiol 2015, 41(2): 150-64. (#并列第一作者,*通讯作者)
    (5) Shanshan Li, Lingbao Kong*, Xilan Yu and Yi Zheng*. Host-virus interactions: From the perspectives of epigenetics. Rev Med Virol 2014, 24(4): 223-41. 
    (6) Shanshan Li, Xilan Yu, Yunli Guo, Lingbao Kong*. Interaction networks of hepatitis C virus NS4B: Implications for antiviral therapy. Cell Microbiol 2012, 14(7): 994-1002. 
    (7) Shanshan Li, Linbai Ye, Xilan Yu, Bo Xu, Kuntai Li, Xiangdong Zhu, Haoju Liu, Xiaoyu Wu, Lingbao Kong*. Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-κB activation. Virology 2009, 391(2): 257-64.
    (8) Shanshan Li, Xilan Yu, Gwyn A. Beattie*. Glycine betaine catabolism contributes to Pseudomonas syringae tolerance to hyperosmotic stress by relieving betaine-mediated suppression of compatible solute synthesis. J Bacteriol 2013, 195(10): 2415-23.
    (9) Lingbao Kong#,*, Shanshan Li#,*, Mingjie Huang, Ying Xiong, Qinghua Zhang, Li Ye, Jing Liu, Xiangdong Zhu, Ruina Sun, Yunli Guo. The roles of endoplasmic reticulum overload response induced by HCV and NS4B protein in human hepatocyte viability and virus replication. PLoS One 2015, 10(4):e0123190. (#并列第一作者,*通讯作者)
    (10) Lingbao Kong#,*, Shanshan Li#,*, Qingjiao Liao, Yanni Zhang, Ruina Sun, Xiangdong Zhu, Qinghua Zhang, Jun Wang, Xiaoyu Wu, Xiaonan Fang, Ying Zhu. Oleanolic acid and ursolic acid: novel Hepatitis C virus antivirals that inhibit NS5B activity. Antiviral Res 2013, 98(1), 44-53. (#并列第一作者,*通讯作者)
    (11) Chilaing Chen, Shanshan Li, Dana R. McKeever, Gwyn A Beattie. The widespread plant-colonizing bacterial species Pseudomonas syringae detects and exploits an extracellular pool of choline in hosts. Plant J 2013, 75(6): 891-902. 
    (12) Lingbao Kong, Shanshan Li, Xue Han, Zhonghua Xiang, Xiaonan Fang, Baozong Li, Wei Wang, Hong Zheng, Jingrong Gao, Linbai Ye. Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi. Virus Res 2007, 128(1), 9-17.
    (13) Lixin Qiu, Bicheng Hu, Hongbo Chen, Shanshan Li, Yuqian Hu, Yi Zheng*, Xinxing Wu*. Antifungal efficacy of itraconazole-loaded TPGS-b-(PCL-ran-PGA) nanoparticles. Int J Nanomedicine 2015, 10:1415-23.
    (14) Yongqiang Zhu, Yi Zheng*, Lin Mei, Mengqiong Liu, Shanshan Li, Huawei Xiao, Huijun Zhu, Shu Wu, Hongbo Chen, Laiqiang Huang*. Enhanced immunotherapeutic effect of modified HPV16 E7-pulsed dendritic cell vaccine by an adeno-shRNA-SOCS1 virus. Int J Oncol 2013, 43(4):1151-9.
    (15) Xiaonan Fang, Linbai Ye*, Yijuan Zhang, Baozong Li, Shanshan Li, Lingbao Kong, Yuhua Wang, Hong Zheng, Wei Wang, Zenghui Wu. Nucleocapsid amino acids 211 to 254, in particular, tetrad glutamines, are essential for the interaction between the nucleocapsid and membrane proteins of SARS-associated coronavirus. J Microbiol 2006, 44(5):577-80.
    (16) Baozong Li, Bo Gao, Linbai Ye*, Xue Han, Wei Wang, Lingbao Kong, Xiaonan Fang, Yingchun Zeng, Hong Zheng, Shanshan Li, Zenghui Wu, Li Ye. Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res 2007, 124(1-2):44-9.
    (17) Xiaonan Fang, Linbai Ye*, Khalid Amine Timani, Shanshan Li, Yingchun Zen, Meng Zhao, Hong Zheng, Zhenghui Wu. Peptide domain involved in the interaction between membrane protein and nucleocapsid protein of SARS-associated coronavirus. BMB Reports 2005, 38(4), 381-385.
    (18) 刘静, 阳帆, 李珊珊, 王玉华, 杨小骏, 吴正辉, 郜金荣, 叶林柏*。灵芝多糖 GLP 的抗疱疹病毒作用机理。中国病毒学,2005,20 (4):362~365.
     
    会议特邀学术报告
    (1) Shanshan Li, Jerry L. Workman, Tamaki Suganuma*. Metabolism, Transcription and Disease (J2),Utah,10-14 January, 2016
    (2) Shanshan Li, Xilan Yu, Gwyn A. Beattie*. Characterization of phosphorylcholine catabolism and osmoprotection in Pseudomonas syringae,第71届美国微生物协会北美分会,得美因,美国,2011年10月
    (3) Shanshan Li and Michael A. Shogren-Knaak*. Regulation of SAGA-mediated Histone acetylation by chromatin structure,Coeur D'Alene,Idaho,2009年2月
     
    备注:
    本实验室长期招聘研究生、博士和博士后,待遇从优。欢迎有志于从事科学研究的研究生加入。
    了解更多信息:http://www.cell.com/molecular-cell/meet-the-author/li

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