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  • 陈勇
  • 作者:系统管理员    发布日期:2013-09-06    点击率:
  • 姓  名: 陈勇
    办公电话: 027-88661237-8046
    电子邮件: cy101610@yahoo.com
    通讯地址: 湖北省武汉市武昌区友谊大道368号湖北大学生命科学学院
    基本情况简介:博士,二级教授、博士研究生导师、湖北大学中药生物技术省重点实验室主任、药物高通量筛选省工程实验室主任、生物医药研究生教育省创新基地主任,以及微生物与生化药学省重点学科负责人
    主要社会兼职: 药学学报、中草药、应用基础与工程科学学报、中华现代中医学杂志等刊物编委,全国有机分析专业委员会理事
    主要研究领域:主要从事分子药理学和药代动力学研究
    学习和工作简历:
     1983年9月-1987年7月:武汉大学化学系四年制本科生;
     1987年9月-1990年7月:武汉大学化学系三年制硕士生;
     1990年8月-1993年12月::北京大学化学与分子工程学院四年制博士生;
     1993年12月-1995年11月:中科院研究生院化学部博士后;
     1995年12月-现在:湖北大学生命科学学院教授、博士生导师。
     

    承担科研项目情况:
    1. 杜仲叶、山麦冬标准提取物研究。01年武汉市科委重大科技攻关项目(50万,No.20016001008),主持人
    2. 指纹图谱应用示范研究。科技部十五攻关项目(中医药现代化研究与产业化开发)(程翼宇主持,No.2001BA701A01),联合申报单位负责人(分配经费10万)
    3. 中药标准提取物及其指纹图谱研究。湖北省青年杰出人才科学基金(10万,No.2002AC004),主持人
    4. 慢性肝炎中医“证”分型的分子基础研究。国家重大基础研究前期专项(30万,No.2002ccc00300),主持人
    5. 用于中药临床前安全性评价的毒理芯片开发研究。湖北省科技厅(6万,No.2004AA303B05)和武汉市科技局重点攻关项目(10万,No.20036003042),主持人
    6. 确有疗效复方中药痹祺胶囊的药代动力学研究。07年国家自然科学基金重点项目(刘昌孝院士主持,No.30630075),联合申报单位主持人(分配经费35万)
    7. 复方脉君安片的药动学与分子药理学研究。湖北省高等学校优秀中青年团队计划项目(32万,No.T200807),主持人
    8. 浓缩型脉君安片临床前研究。湖北省发改委生物产业专项项目(No.鄂发改高技  [2008] 1365号-1,40万),主持人
    9. 抗乙肝病毒药物筛选关键技术。湖北省发改委生物产业专项项目(湖北省生物产业专项,No.鄂发改投资[2009]1734号,50万),主持人
    10. 与乙型病毒性肝炎病毒生活周期相关的细胞因子或靶分子。艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项课题(吴建国主持,No.2008ZX10204),联合申报单位负责人(分配经费20万)

    获得的授权发明专利
    1.陈勇,李紫,蔡敏。山麦冬多糖提取工艺。发明专利,专利号ZL 02147758.2
    2. 韩凤梅,杜鹏,郭小龙,陈勇。一种以枸杞酒渣为原料制备高免疫调节活性枸杞多糖的酶解工艺。发明专利,专利授权号ZL 200710052400.7
    3. 陈勇,韩凤梅,张继业,张仙,王恒松。一种服用剂量小的浓缩型脉君安片或胶囊配方及其制备方法。发明专利,专利授权号ZL 200810048199.X

    作为通讯作者发表的主要研究论文
    1.  Huaixia Chen, Yong Chen, Hong Wang, Peng Du, Fengmei Han, Huashan Zhang. Analysis of scopolamine and its eighteen metabolites in rat urine by LC tandem mass spectrometry. Talanta, 2005, 67: 984-991
    2.  Huaixia Chen, Hong Wang, Yong Chen, Huangshan Zhang.Liquid chromatography-tandem mass spectrometry analysis of anisodamine and its phaseI and II metabolites in rat urine. J. chromatography B, 2005, 824: 21-29
    3.  Yong Chen, Huaixia Chen, Peng Du, Fengmei Han, Huashan Zhang, The Analysis of Anisodine and the Identification of Twenty of Its Metabolites in Rat Urine by Liquid Chromatography-Tandem Mass Spectrometry. Chromatographia, 2005,62:563-569
    4.  Huaixia Chen, Yong Chen, Peng Du, Fengmei Han, Hong Wang, Huashan Zhang. Sensitive and specific liquid chromatographic-tandem mass spectrometric assay for atropine and its eleven metabolites in rat urine. J. Pharmaceutical and Biomedical Analysis,2006,40:142
    5.  HAN Feng-Mei, CHENG Ming, XIA Qi-Song, CHEN Yong. Gene expression profile in immunologically injured liver cell of mice. Science in China Series C-Life Sciences,2006,49(5):454-459
    6.  M.M. Zhu, H.X. Chen, F.M. Han, Y. Chen. Analysis of Arecoline and Identification of Its Metabolites in Rat Urine by Liquid Chromatography-Tandem Mass Spectrometry. Chromatographia,2006,64(11/12):705-708
    7.  H.X. Chen, Y.Chen, P.Du, F.M. Han. LC-MS for identification and elucidation of the structure of in-vivo and in-vitro metabolites of atropine. Chromatographia, 2007, 65:413-418
    8.  Mingming Zhu, Fengmei Han, Huaixia Chen, Zhihong Peng Yong Chen. Identification of palmatine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Rapid communications in mass spectrometry, 2007, 21(13):2019-2022
    9.  Yong Chen, Xiao-ming Zhang, Feng-mei Han, Peng Du, Qi-song Xia.  Gene expression profiling analyses of injured mice livers by Leigongteng(Tripterygium Wilfordii Hook. f.). World Journal of gastroenterology, 2007, 13(26):3619-3624
    10.  F.M.Han, Z.H.Peng, W.Song, H.M.Zhang, M.M.Zhu, Y.Chen. Identification of dauricine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. J. of Chromatography B, 2007, 854(1/2):1-7
    11.  Huaixia Chen, Yong Chen, Peng Du, Fengmei Han. Structural elucidation of in –vivo and in-vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry. J. of Pharmaceutical and Biomedical Analysis. 2007, 44(3):773-778
    12.  Y. Chen, Z.H. Peng, M.M.Zhu, F.M. Han. Chromatographic tandem mass spectrometric detection of papaverine and its major metabolites in rat urine. International J.of Mass Spectrometry, 2007, 266:114-121
    13.  B.Y. Ge , H.X. Chen , F.M. Han , Y. Chen. Identification of Amygdalin and its major metabolites in Rat Urine by LC-MS/MS. J.of Chromatography B, 2007, 857:281-286
    14.  Wei Song, Zhihong Peng, Baoying Ge, Fengmei Han, Yong Chen. Identification of metabolites of lobeline in the rat urine by liquid chromatography - tandem mass spectrometry. International J.of Mass Spectrometry, 2007, 269:131-137
    15.  Y. Chen*; Z. H. Peng ; W. Song ; M. M. Zhu; F. M. Han. Chromatographic Tandem Mass Spectrometric Detection of Physostigmine and its Major Metabolites in Rat Urine. Analytical Letters, 2007 (40) :3256-3266
    16.  Y. Chen, W. Song, Z. H. Peng, B.Y. Ge, F.M. Han. Identification of metabolites of tectoridin in vivo and in vitro by liquid chromatography - tandem mass spectrometry. J. of Pharmacy and Pharmacology, 2008, 60: 1-8
    17.  Yi zhang, Wenhua Wu,Fengmei Han, Yong Chen. LC/MS/MS for identification of in vivo and in vitro metabolites of jatrorrhizine. Biomedical Chromatography, 2008, 22(12):1360-1367(SCI)
    18.  Qian C. Yang, Wen H. Wu, Feng M. Han, Yong Chen. Identification of in vivo and in vitro metabolites of palmatine by liquid chromatography-tandem mass spectrometry. J. of Pharmacy and Pharmacology, 2009, 61:647-652
    19.  Xingxing Kong, Heng Fan, Xiaojun Liu, Rui Wang, Jichao Liang, Nishith Gupta, Yong Chen, Fude Fang, Yongsheng Chang. Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Enhances Antiproliferative Activity of 5′-Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase. Molecular Pharmacology, 2009, 76:854-860
    20.  Peng ZH, Song W, Han FM, Chen Y. In vivo and in vitro study of papaverine and its major metabolites. Acta Phamaceutica Sinica, 2009 (44):95-100
    21.  Feng-mei Han, Qian-cheng Yang, Peng Du, Wen-hua Wu, Yong Chen. The metabolism of strychnine in rat liver microsomes and metabolic interaction with glycyrrhetic acid in vitro. Asian Journal of Pharmacodynamics and Pharmacokinetics, 2009, 9(4):301-312
    22.  F.M.Han, M.M.Zhu, H.X.Chen, Y.Chen. Identification of sophoridine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Analytical Letters, 2010, 43(1):45-54
    23.  Liu-Luan Zhu, Yang Liu, An-Fang Cui, Di Shao, Ji-Chao Liang, Xiao-Jun Liu, Yong Chen, Nishith Gupta, Fu-De Fang, Yong-Sheng Chang. PGC-1α coactivates estrogen-related receptor-α to induce the expression of glucokinase. Am J Physiol Endocrinol Metab. 2010, 298: 1210–E1218.
    24.  Xingxing Kong, Rui Wang, Yuan Xue, Xiaojun Liu, Huabing Zhang, Yong Chen, Fude Fang, Yongsheng Chang. Sirtuin 3, a New Target of PGC-1a, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis. PLoS One. 2010, 5: 1-13
    25.  Yang QC, Han FM, Xiong YQ, Xing PP, Chen Y. The metabolism of glycyrrhetic acid in rat liver microsomes and in vitro metabolic interaction with six CYP450 probe substrates. Asian J of Pharmacodynamics and Pharmacokinetics, 2010, 10(4):310-319
    26.  Li Liu, Juan Xiao, Zhihong Peng, Yong Chen. In vitro metabolism of glycyrrhetic acid by human cytochrome P450. Acta Phamaceutica Sinica, 2011,46(1):81-87
    27.  XING Pan-pan, WUWen-hua, DU Peng, HAN Feng-mei, CHEN Yong. Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo[J]. Acta Pharmaceutica Sinica 2011, 46 (5): 573-580.
    28.  Qian Gao,Jun-junWang,Feng-meiHan,YongChen. Effect of strychnine hydrochloride on liver cytochrome P450 mRNA expression and monooxygenase activities in rat[J]. Acta  Pharmaceutica SinicaB,2011;1(2):121–128.
    29.  Aijun Qiao, Jichao Liang, Yaojun Ke, Chenghong Li, Ying Cui, Lian Shen, Huabing Zhang, Anfang Cui, Xiaojun Liu, Changzheng Liu, Yong Chen,Yi Zhu, Youfei Guan, Fude Fang, and Yongsheng Chang. Mouse Patatin-Like Phospholipase Domain-Containing 3 Influences Systemic Lipid and Glucose Homeostasis[J]. Hepatology, 2011, 54(2):509-521.
    30.  Zhi-hong Peng, Jun-jun Wang, Peng Du, Yong Chen. Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography–tandem mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis, 2012,70:624– 630.
    31.  Jichao Liang, Fengmei Han, Yong Chen. An electrochemical method for high sensitive detection of nicotine and its interaction with bovine serum albumin[J]. Electrochemistry Communications ,2012,24:93–96.
    32.  Jichao Liang, Changzheng Liu,  Aijun Qiao, Ying Cui2, , Huabing Zhang, Anfang Cui, Shutian Zhang, Yanli Yang, ,Xinhua Xiao, Yong Chen, Fude Fang, Yongsheng Chang. MicroRNA-29a-c decrease fasting blood glucose levels by negatively regulating hepatic gluconeogenesis[J]. Journal of Hepatology ,2013,58: 535–542.
    33.  Xiao-min Chen, Min Wei, Hai-mou Zhang, Cheng-hao Luo, Yi-kun Chen, Yong Chen. Effect of vanillin and ethyl vanillin on Cytochrome P450 activity in vitro and in vivo[J].  Food Chem Toxicol, 2012, 50(6):1897-1901
    34.  Yi Mingjing, Peng Wei, Chen Xiaomin, Wang Junjun, Chen Yong. Effect of hypaconitine combined with liquiritin on the expression of Calmodulin and Connexin43 in rat cardiac muscle in vivo o[J]. Journal of Pharmacy and Pharmacology. 2012,64:1654–1658.
    35.  LIU Li, XIAO Juan, PENG Zhi-hong, WU Wen-hua, DU Peng, CHEN Yong. In vitro Metabolism of Strychnine by Human Cytochrome P450 and Its Interaction with Glycyrrhetic Acid o[J]. Chinese Herbal Medicines, 2012, 4(2): 118-125.

     

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